Interleukin-15 (IL-15) Can Replace the IL-2 Signal in IL-2–Dependent Adult T-Cell Leukemia (ATL) Cell Lines: Expression of IL-15 Receptor α on ATL Cells

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 2,119 citations

Adult T-cell leukemia: clinical and hematologic features of 16 cases

1977 • 1,750 citations

Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor

1994 • 1,423 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.

1995 • 627 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation.

1995 • 445 citations

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 417 citations

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I.

1987 • 413 citations

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

1994 • 396 citations

Functional Characterization of the Human Interleukin-15 Receptor αChain and Close Linkage of IL15RA and IL2RA Genes

1995 • 363 citations

Chemoattraction of human blood T lymphocytes by interleukin-15.

1995 • 303 citations

Differential effects of interleukin-15 (IL-15) and IL-2 on human neutrophils: modulation of phagocytosis, cytoskeleton rearrangement, gene expression, and apoptosis by IL-15

1996 • 237 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

Studies Evaluating the Antitumor Activity and Toxicity of Interleukin-15, a New T Cell Growth Factor: Comparison with Interleukin-2

1995 • 204 citations

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms.

1997 • 182 citations

Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma

1983 • 166 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Interleukin-15 Triggers the Proliferation and Cytotoxicity of Granular Lymphocytes in Patients With Lymphoproliferative Disease of Granular Lymphocytes

1997 • 119 citations

Pulmonary complications in patients with adult T-cell leukemia

1985 • 114 citations

Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor.

1995 • 107 citations

Ultraviolet B radiation up-regulates the expression of IL-15 in human skin.

1995 • 104 citations

Central nervous system involvement in adult T-cell leukemia/lymphoma

1990 • 96 citations

Interleukin-15 promotes the growth of leukemic cells of patients with B- cell chronic lymphoproliferative disorders

1996 • 93 citations

Interleukin‐15 up‐regulates interleukin‐2 receptor α chain but down‐regulates its own high‐affinity binding sites on human T and B cells

1996 • 67 citations

IL-15: the role of translational regulation in their expression

1996 • 62 citations

Adult T-cell leukemia with leukemia cell infiltration into the gastrointestinal tract

1988 • 57 citations

Relation of oxidative stress and glutathione synthesis to CD95(Fas/APO-1)-mediated apoptosis of adult T cell leukemia cells.

1996 • 56 citations

Interaction of IL-15 with the shared IL-2 receptor beta and gamma c subunits. The IL-15/beta/gamma c receptor-ligand complex is less stable than the IL-2/beta/gamma c receptor-ligand complex.

1996 • 56 citations

Frequent Hepatic Involvement in Adult T Cell Leukemia: Comparison with non-Hodgkin's Lymphoma

1997 • 37 citations

IL-2-Dependent ATL cell lines with phenotypes differing from the original leukemia cells

1991 • 35 citations

Expression of interleukin-15 and its receptor by human fetal retinal pigment epithelial cells

1996 • 29 citations

Established IL‐2‐dependent double‐negative (CD4^‐ CD8^‐) TCRαβ/CD3⁺ ATL cells: induction of CD4 expression

1994 • 27 citations