Neuronal nicotinic receptors: from structure to pathology

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

2000 • 3,789 citations

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

2002 • 2,972 citations

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

2001 • 1,736 citations

Presynaptic nicotinic ACh receptors

1997 • 1,313 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy

1995 • 1,112 citations

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat

1989 • 1,049 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

1995 • 1,017 citations

Cholinergic systems in mammalian brain and spinal cord

1991 • 942 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells

1994 • 869 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Neuronal nicotinic receptors in the human brain

2000 • 782 citations

β-Amyloid1–42 Binds to α7 Nicotinic Acetylcholine Receptor with High Affinity

2000 • 781 citations

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis

2001 • 781 citations

Nicotinic Receptors in the Development and Modulation of CNS Synapses

1996 • 771 citations

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

1994 • 741 citations

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival

1989 • 733 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells

2001 • 671 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

Autoantibodies to Ganglionic Acetylcholine Receptors in Autoimmune Autonomic Neuropathies

2000 • 658 citations

Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei.

2001 • 640 citations

Nicotinic acetylcholine receptors and the regulation of neuronal signalling

2004 • 584 citations

Turning of nerve growth cones induced by neurotransmitters

1994 • 583 citations

PRESYNAPTIC IONOTROPIC RECEPTORS AND THE CONTROL OF TRANSMITTER RELEASE

1999 • 578 citations

Molecular and Physiological Diversity of Nicotinic Acetylcholine Receptors in the Midbrain Dopaminergic Nuclei

2001 • 574 citations

A glia-derived acetylcholine-binding protein that modulates synaptic transmission

2001 • 564 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

1991 • 515 citations

Transdermal Nicotine for Active Ulcerative Colitis

1994 • 510 citations

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

2003 • 506 citations

Subunit Composition of Functional Nicotinic Receptors in Dopaminergic Neurons Investigated with Knock-Out Mice

2003 • 504 citations

Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase

1988 • 496 citations

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

1997 • 493 citations

The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type

1989 • 491 citations

Cholinergic modulation of microglial activation by α7 nicotinic receptors

2004 • 491 citations

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

2003 • 488 citations

Nicotinic acetylcholine receptors: from structure to brain function

2003 • 487 citations

A New α-Conotoxin Which Targets α3β2 Nicotinic Acetylcholine Receptors

1996 • 479 citations

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

1991 • 463 citations

Effect of nicotine and nicotinic receptors on anxiety and depression

2002 • 454 citations

Nicotinic receptors in the brain: correlating physiology with function

1999 • 450 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Nicotinic acetylcholine receptors in health and disease

1997 • 446 citations

The nicotinic receptor β2 subunit is mutant in nocturnal frontal lobe epilepsy

2000 • 441 citations

Allosteric Receptors after 30 Years

1998 • 430 citations

Molecular evolution of the nicotinic acetylcholine receptor: An example of multigene family in excitable cells

1995 • 422 citations

Amyloid Peptide Aβ_1‐42 Binds Selectively and with Picomolar Affinity to α7 Nicotinic Acetylcholine Receptors

2000 • 421 citations

Human neuronal nicotinic receptors

1997 • 418 citations

Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

2004 • 409 citations

Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

2003 • 406 citations

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

2002 • 400 citations

Functional contributions of α5 subunit to neuronal acetylcholine receptor channels

1996 • 389 citations

Identification of four classes of brain nicotinic receptors using beta2 mutant mice.

1998 • 388 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Cholinergic Activity in Autism: Abnormalities in the Cerebral Cortex and Basal Forebrain

2001 • 371 citations

An Insertion Mutation of the CHRNA4 Gene in a Family With Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

1997 • 357 citations

Characterization of Nicotinic Receptor‐Mediated [³H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

1992 • 352 citations

Nicotinic Receptors in the Brain Links between Molecular Biology and Behavior

2000 • 352 citations

Nicotinic receptor subtypes and cognitive function

2002 • 349 citations

Mice Lacking Specific Nicotinic Acetylcholine Receptor Subunits Exhibit Dramatically Altered Spontaneous Activity Patterns and Reveal a Limited Role for Retinal Waves in Forming ON and OFF Circuits in the Inner Retina

2000 • 347 citations

Smoking and schizophrenia

1992 • 346 citations

Distribution and Pharmacology of α6-Containing Nicotinic Acetylcholine Receptors Analyzed with Mutant Mice

2002 • 342 citations

Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia

2000 • 340 citations

Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits

1996 • 338 citations

Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems

1995 • 338 citations

Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices.

1997 • 330 citations

β-Amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons

2001 • 326 citations

Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice

1998 • 323 citations

CHRNB2 Is the Second Acetylcholine Receptor Subunit Associated with Autosomal Dominant Nocturnal Frontal Lobe Epilepsy*

2001 • 317 citations

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

1991 • 313 citations

Smoking and mental illness

2001 • 309 citations

Human reticular formation: Cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons

1989 • 301 citations

Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys

1999 • 300 citations

Long-term tacrine (Cognex) treatment

1996 • 300 citations

Nicotinic receptor function: new perspectives from knockout mice

2000 • 297 citations

Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.

1990 • 288 citations

Characterization of <scp>l</scp>‐[³H]Nicotine Binding in Human Cerebral Cortex: Comparison Between Alzheimer's Disease and the Normal

1986 • 288 citations

Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor

1999 • 286 citations

Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors.

1995 • 284 citations

β-Amyloid_1–42Peptide Directly Modulates Nicotinic Receptors in the Rat Hippocampal Slice

2001 • 284 citations

Multiorgan Autonomic Dysfunction in Mice Lacking the β2 and the β4 Subunits of Neuronal Nicotinic Acetylcholine Receptors

1999 • 281 citations

Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine.

1999 • 280 citations

Nicotinic acetylcholine receptors as targets for antidepressants

2002 • 270 citations

Nicotinic and muscarinic subtypes in the human brain: Changes with aging and dementia

1992 • 269 citations

Human Keratinocytes Synthesize, Secrete, and Degrade Acetylcholine

1993 • 268 citations

Release of [³H]‐noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [³H]‐dopamine release

1996 • 263 citations

Nicotinic Receptor Function in Schizophrenia

1996 • 261 citations

Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics

2002 • 259 citations

Nicotine as a modulator of behavior: beyond the inverted U

2003 • 254 citations

Immunocytochemical localization of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system

1994 • 247 citations

Neuronal acetylcholine receptors that bind alpha-bungarotoxin mediate neurite retraction in a calcium-dependent manner

1994 • 246 citations

Requirement of the nicotinic acetylcholine receptor β2 subunit for the anatomical and functional development of the visual system

2001 • 246 citations

Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors

2003 • 245 citations

Measuring nicotinic receptors with characteristics of α4β2, α3β2 and α3β4 subtypes in rat tissues by autoradiography

2002 • 241 citations

Human vascular endothelial cells express functional nicotinic acetylcholine receptors.

1998 • 240 citations

Nicotinic receptor abnormalities in Alzheimer’s disease

2001 • 237 citations

Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse.

2000 • 236 citations

Smoking and Parkinson’s and Alzheimer’s disease: review of the epidemiological studies

2000 • 235 citations

Comparison of the regional expression of nicotinic acetylcholine receptor ?7 mRNA and [125I]-?-bungarotoxin binding in human postmortem brain

1997 • 233 citations

Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors

1998 • 233 citations

Nicotinic receptor abnormalities in the cerebellar cortex in autism

2002 • 232 citations

Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro

1998 • 230 citations

β-Amyloid Peptide Activates α7 Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes

2002 • 228 citations

Involvement of Nicotinic Acetylcholine Receptors in Suppression of Antimicrobial Activity and Cytokine Responses of Alveolar Macrophages to Legionella pneumophila Infection by Nicotine

2001 • 228 citations

Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.

2003 • 226 citations

Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors

2001 • 217 citations

Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications

2001 • 214 citations

Nicotinic receptors in aging and dementia

2002 • 209 citations

Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels

2002 • 207 citations

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors

1999 • 207 citations

Four Pharmacologically Distinct Subtypes of α4β2 Nicotinic Acetylcholine Receptor Expressed inXenopus laevisOocytes

1998 • 207 citations

A Nicotinic Acetylcholine Receptor Regulating Cell Adhesion and Motility Is Expressed in Human Keratinocytes

1995 • 206 citations

FDG PET and Differential Diagnosis of Dementia

1995 • 205 citations

The β3 Nicotinic Receptor Subunit: A Component of α-Conotoxin MII-Binding Nicotinic Acetylcholine Receptors that Modulate Dopamine Release and Related Behaviors

2003 • 205 citations

Abnormal Functional Organization in the Dorsal Lateral Geniculate Nucleus of Mice Lacking the β2 Subunit of the Nicotinic Acetylcholine Receptor

2003 • 204 citations

The spectrum of autoimmune autonomic neuropathies

2003 • 203 citations

A Novel Human Nicotinic Receptor Subunit, α10, That Confers Functionality to the α9-Subunit

2002 • 203 citations

Phenotypic Characterization of an α₄ Neuronal Nicotinic Acetylcholine Receptor Subunit Knock-Out Mouse

2000 • 202 citations

Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain

2004 • 200 citations

Nicotinic Modulation of [³H]Dopamine Release from Striatal Synaptosomes: Pharmacological Characterisation

1990 • 198 citations

Nicotinic α7 receptors: Synaptic options and downstream signaling in neurons

2002 • 195 citations

The Nicotinic Acetylcholine Receptor Subunit α5 Mediates Short-Term Effects of Nicotine in Vivo

2003 • 192 citations

Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious

1996 • 190 citations

A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy

1999 • 189 citations

Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin

1996 • 189 citations

Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the ?7-nicotinic acetylcholine receptor subunit gene (CHRNA7)

2001 • 185 citations

Dose‐related neuroprotective effects of chronic nicotine in 6‐hydroxydopamine treated rats, and loss of neuroprotection in α4 nicotinic receptor subunit knockout mice

2001 • 182 citations

The Non-neuronal Cholinergic System: an Emerging Drug Target in the Airways

2001 • 182 citations

Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons

1999 • 181 citations

Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety

2001 • 180 citations

Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease

2003 • 177 citations

The effects of nicotine on Parkinson's disease.

2000 • 175 citations

Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

1997 • 173 citations

Tobacco-Specific Carcinogenic Nitrosamines

1998 • 168 citations

Kappa-Bungarotoxin: a probe for the neuronal nicotinic receptor in the avian ciliary ganglion

1983 • 167 citations

Genetic influences on nicotine responses

1989 • 167 citations

Nicotine and Cotinine Modulate Cerebral Microvascular Permeability and Protein Expression of ZO-1 through Nicotinic Acetylcholine Receptors Expressed on Brain Endothelial Cells

2002 • 165 citations

Nicotinic receptor binding of [3H]cytisine, [3H]nicotine and [3H]methylcarbamylcholine in rat brain

1994 • 162 citations

Nicotinic receptor signaling in nonexcitable cells

2002 • 161 citations

The lymphocytic cholinergic system and its biological function

2003 • 161 citations

Neuroreceptor changes in Alzheimer disease.

1992 • 161 citations

Executive and social behaviors under nicotinic receptor regulation

2003 • 160 citations

Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

2003 • 159 citations

Localization of nAChR subunit mRNAs in the brain of Macaca mulatta

2000 • 157 citations

Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson’s disease and Alzheimer’s disease and in relation to neuroleptic medication

2000 • 155 citations

The genetics of sensory gating deficits in schizophrenia

2003 • 153 citations

Functional contribution of the α7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones

1998 • 152 citations

Prevalence of smoking in psychiatric patients

2002 • 150 citations

Involvement of the α3 Subunit in Central Nicotinic Binding Populations

2002 • 150 citations

Nicotinic cholinoceptive neurons of the frontal cortex are reduced in Alzheimer's disease

1991 • 149 citations

The genetics of human epilepsy

2003 • 146 citations

Three subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors are expressed in chick retina

1993 • 142 citations

Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium

2002 • 140 citations

Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer

2003 • 138 citations

Antidepressants Noncompetitively Inhibit Nicotinic Acetylcholine Receptor Function

1999 • 137 citations

Molecular analysis of nicotinic receptor expression in autism

2004 • 136 citations

Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.

1996 • 133 citations

Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma

1994 • 133 citations

Passive Transfer of Autoimmune Autonomic Neuropathy to Mice

2004 • 132 citations

Early developmental changes in [3H]nicotine binding in the human brainstem

1993 • 130 citations

The kinetic properties of neuronal nicotinic receptors: Genetic basis of functional diversity

1993 • 130 citations

Nicotine and Nicotinic Receptors; Relevance to Parkinson’s Disease

2002 • 129 citations

Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion

1995 • 129 citations

Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery.

2001 • 126 citations

Presynaptic Nicotinic Receptors and the Modulation of Transmitter Release

2007 • 126 citations

Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cells

1996 • 126 citations

Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

1979 • 125 citations

Synaptic localization of alpha-bungarotoxin binding which blocks nicotinic transmission at frog sympathetic neurons.

1981 • 119 citations

Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems

2003 • 118 citations

Contribution of CNS nicotine metabolites to the neuropharmacological effects of nicotine and tobacco smoking

1997 • 117 citations

Functional α6-Containing Nicotinic Receptors Are Present in Chick Retina

1999 • 117 citations

β2-Containing Nicotinic Receptors Contribute to the Organization of Sleep and Regulate Putative Micro-Arousals in Mice

2004 • 116 citations

Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration.

2000 • 115 citations

Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. Part II

1997 • 113 citations

β-Amyloid Directly Inhibits Human α4β2-Nicotinic Acetylcholine Receptors Heterologously Expressed in Human SH-EP1 Cells

2004 • 113 citations

Interaction of tobacco-specific toxicants with the neuronal α7 nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders

2000 • 111 citations

Nicotinic Receptor Subtypes in the Developing Chick Brain: Appearance of a Species Containing the α4, β2, and α5 Gene Products

1998 • 110 citations

α‐Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes

2004 • 109 citations

Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

2001 • 109 citations

The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension.

1996 • 108 citations

Neuronal Acetylcholine Receptors with α7 Subunits Are Concentrated on Somatic Spines for Synaptic Signaling in Embryonic Chick Ciliary Ganglia

1999 • 108 citations

The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type

1997 • 107 citations

Mammalian Nicotinic Receptors with α7 Subunits That Slowly Desensitize and Rapidly Recover from α-Bungarotoxin Blockade

1998 • 107 citations

Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines.

1992 • 106 citations

Inflammatory Bowel Disease and Smoking—A Review

1998 • 104 citations

Selective activation of central subtypes of the nicotinic acetylcholine receptor has opposite effects on neonatal excitotoxic brain injuries

2002 • 102 citations

Activation of α₇ nicotinic acetylcholine receptor promotes survival of spinal cord motoneurons

1997 • 101 citations

Localization of [³H]nicotine, [³H]cytisine, [³H]epibatidine, and [¹²⁵I]α‐bungarotoxin binding sites in the brain of Macaca mulatta

2003 • 100 citations

Molecular Cloning and Chromosomal Localization of the Human α7-Nicotinic Receptor Subunit Gene (CHRNA7)

1994 • 99 citations

A Reporter Mutation Approach Shows Incorporation of the “Orphan” Subunit β3 into a Functional Nicotinic Receptor

1998 • 99 citations

Receptor‐mediated effects of nicotine and its nitrosated derivative NNK on pulmonary neuroendocrine cells

2002 • 99 citations

The effects of nicotine plus haloperidol compared to nicotine only and placebo nicotine only in reducing tic severity and frequency in Tourette's disorder

1992 • 98 citations

Heterogeneity and Regulation of Nicotinic Acetylcholine Receptors

1992 • 98 citations

Idiopathic Autonomic Neuropathy

2004 • 98 citations

Pharmacology and Biophysical Properties of α7 and α7 ‐ α8 α‐Bungarotoxin Receptor Subtypes Immunopurified from the Chick Optic Lobe

1994 • 97 citations

Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia

2003 • 97 citations

Amyloid 1-42 peptide alters the gating of human and mouse -bungarotoxin-sensitive nicotinic receptors

2003 • 94 citations

Functional contribution of the α5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones

1998 • 93 citations

α-Bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line

1994 • 92 citations

Synthesis and release of acetylcholine by cultured bovine arterial endothelial cells

1990 • 92 citations

Knock-out and Knock-in Mice to Investigate the Role of Nicotinic Receptors in the Central Nervous System

2002 • 91 citations

Nicotinic Acetylcholine Receptor Agonists: A Potential New Class of Analgesics

2004 • 91 citations

The Structures of Neuronal Nicotinic Receptors

2000 • 91 citations

Distribution of Nicotinic Subtypes in Human Brain

1995 • 90 citations

Mice lacking neuronal nicotinic acetylcholine receptor β4-subunit and mice lacking both α5- and β4-subunits are highly resistant to nicotine-induced seizures

2004 • 90 citations

Immunohisto- and cytochemical localization of cortical nicotinic cholinoceptors in rat and man

1989 • 90 citations

Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience

2004 • 89 citations

[3H]Nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day

2000 • 88 citations

Neuronal and astrocyte expression of nicotinic receptor subunit β4 in the adult mouse brain

2003 • 87 citations

Evidence for linkage disequilibrium between the alpha 7‐nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families*

2001 • 87 citations

Serotonin release and cell proliferation are under the control of α‐bungarotoxin‐sensitive nicotinic receptors in small‐cell lung carcinoma cell lines

1994 • 86 citations

Differential Declines in Striatal Nicotinic Receptor Subtype Function after Nigrostriatal Damage in Mice

2003 • 86 citations

Distribution of nicotinic receptors in cynomolgus monkey brain and ganglia: Localization of α3 subunit mRNA, α-bungarotoxin and nicotine binding sites

1992 • 86 citations

Mouse strain‐specific nicotinic acetylcholine receptor expression by inhibitory interneurons and astrocytes in the dorsal hippocampus

2003 • 85 citations

Two distinct classes of functional α7‐containing nicotinic receptor on rat superior cervical ganglion neurons

2000 • 85 citations

Expression of neuronal acetylcholine receptor genes in vertebrate skeletal muscle during development

1995 • 84 citations

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy in a Spanish Family With a Ser252Phe Mutation in the CHRNA4 Gene

1999 • 84 citations

β2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure

2002 • 83 citations

The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: lessons from knockout mice

2002 • 82 citations

Nicotinic receptors in circuit excitability and epilepsy

2002 • 82 citations

Differential nicotinic acetylcholine receptor subunit expression in the human hippocampus

2003 • 81 citations

Chapter 7: Nicotinic receptors in mammalian brain: localization and relation to cholinergic innervation

1993 • 80 citations

Functional Nicotinic Acetylcholine Receptors Are Expressed in B Lymphocyte-Derived Cell Lines

2003 • 80 citations

Autonomic function in mice lacking α5 neuronal nicotinic acetylcholine receptor subunit

2002 • 79 citations

[3H](-)nicotine binding sites in fetal human brain

1988 • 78 citations

Physiopathology of neuronal voltage‐operated calcium channels

1991 • 78 citations

Expression of nicotinic acetylcholine receptors in Alzheimer’s disease: postmortem investigations and experimental approaches

2000 • 77 citations

Nicotine and its metabolite cotinine are mitogenic for human vascular smooth muscle cells

1997 • 77 citations

Nicotinic Acetylcholine Receptors Assembled from the α7 and β3 Subunits

1999 • 77 citations

Stoichiometry of human recombinant neuronal nicotinic receptors containing the β3 subunit expressed in Xenopus oocytes

2000 • 76 citations

Absence of α7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures

2002 • 75 citations

Neuronal nicotinic receptor inhibition for treating mood disorders preliminary controlled evidence with mecamylamine

2002 • 74 citations

Nicotine potentiation of haloperidol in reducing tic frequency in Tourette's disorder [published erratum appears in Am J Psychiatry 1991 Sep;148(9):1282]

1991 • 72 citations

Increased Sensitivity to Nicotine-Induced Seizures in Mice Expressing the L250T α7 Nicotinic Acetylcholine Receptor Mutation

2002 • 71 citations

Nicotine-induced inhibition in medial septum involves activation of presynaptic nicotinic cholinergic receptors on gamma-aminobutyric acid-containing neurons.

1996 • 70 citations

Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. I

1997 • 69 citations

Altered baroreflex responses in α7 deficient mice

2000 • 69 citations

Phenotypic Comparison of Two Scottish Families with Mutations in Different Genes Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

2003 • 67 citations

The role of the cholinergic system in the development of the human cerebellum

1995 • 66 citations

Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells

1997 • 66 citations

Neuronal nicotinic receptors: insights gained from gene knockout an knocking mutant mice

2003 • 65 citations

Loss of α‐conotoxinMII‐ and A85380‐sensitive nicotinic receptors in Parkinson's disease striatum

2004 • 65 citations

Fractional Ca 2+ current through human neuronal α7 nicotinic acetylcholine receptors

2003 • 65 citations

Amacrine, ganglion, and displaced amacrine cells in the rabbit retina express nicotinic acetylcholine receptors

2000 • 65 citations

Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors.

2003 • 64 citations

Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson’s disease

2002 • 64 citations

Selective Nicotinic Receptor Consequences in APPSWE Transgenic Mice

2002 • 64 citations

Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression.

2003 • 63 citations

Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways

2003 • 63 citations

Increased Sensitivity to Agonist-Induced Seizures, Straub Tail, and Hippocampal Theta Rhythm in Knock-In Mice Carrying Hypersensitive α4 Nicotinic Receptors

2003 • 61 citations

Blockade of neuronal facilitatory nicotinic receptors containing α3β2 subunits contribute to tetanic fade in the rat isolated diaphragm

2003 • 61 citations

Heterogeneity of nicotine actions in the rat cerebellum: an in vivo electrophysiologic study.

1987 • 60 citations

The α7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes

2003 • 60 citations

Neuronal‐type nicotinic receptors in human neuroblastoma and small‐cell lung carcinoma cell lines

1992 • 60 citations

The association between smoking and Alzheimer’s disease: effects of study design and bias

2001 • 60 citations

Hippocampal nicotinic autoreceptors modulate acetylcholine release

1993 • 58 citations

Evidence for a noncholinergic nicotine receptor on human phagocytic leukocytes

1982 • 58 citations

Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function

2000 • 58 citations

Effects of Nicotine Exposure on T Cell Development in Fetal Thymus Organ Culture: Arrest of T Cell Maturation

2002 • 57 citations

α4β2 Nicotinic Acetylcholine Receptor Activation Ameliorates Impairment of Spontaneous Alternation Behavior in Stroke-Prone Spontaneously Hypertensive Rats, an Animal Model of Attention Deficit Hyperactivity Disorder

2002 • 56 citations

The vagus nerve, macrophages, and nicotine

2003 • 55 citations

α7 and α8 Nicotinic Receptor Subtypes Immunopurified from Chick Retina have Different Immunological, Pharmacological and Functional Properties

1997 • 54 citations

Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres

1989 • 53 citations

Loss of nicotinic acetylcholine receptor subunits α4 and α7 in the cerebral cortex of Parkinson patients

2003 • 53 citations

Differential expression of nicotinic acetylcholine receptor subunits in fetal and neonatal mouse thymus

2002 • 50 citations

Expression and Transcriptional Regulation of the Human α3 Neuronal Nicotinic Receptor Subunit in T Lymphocyte Cell Lines

1998 • 49 citations

The α7 nicotinic receptors in human fetal brain and spinal cord

2002 • 49 citations

Brain Nicotinic and Muscarinic Receptors in Normal Aging and Dementia

1986 • 49 citations

Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor

2002 • 49 citations

Neuronal nicotinic acetylcholine receptors and autosomal dominant nocturnal frontal lobe epilepsy: a critical review

2001 • 48 citations

Nicotinic receptor expression following nicotine exposure via maternal milk

2002 • 47 citations

Effect of nicotine on the intimal hyperplasia after endothelial removal of the rabbit carotid artery

1997 • 47 citations

Equilibrium Binding of Acetylcholine to the Membrane-Bound Acetylcholine Receptor

1982 • 46 citations

Nootropic Drug Modulation of Neuronal Nicotinic Acetylcholine Receptors in Rat Cortical Neurons

2001 • 45 citations

Action of acetylcholine, muscarine, nicotine and antagonists on the membrane potential of astrocytes in cultured rat brainstem and spinal cord

1988 • 45 citations

Acetylcholine Receptors in Small Cell Carcinomas

1985 • 44 citations

Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells

1998 • 44 citations

Antibodies against neuronal nicotinic receptor subtypes in neurological disorders

2000 • 44 citations

Declines in Different β2* Nicotinic Receptor Populations in Monkey Striatum after Nigrostriatal Damage

2002 • 44 citations

Effect of smoking and transdermal nicotine on colonic nicotinic acetylcholine receptors in ulcerative colitis

2003 • 43 citations

Deficiency of Nicotinic Acetylcholine Receptor β4 Subunit Causes Autonomic Cardiac and Intestinal Dysfunction

2003 • 43 citations

Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease

2000 • 42 citations

Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease

2002 • 41 citations

Nicotine and its interaction with β-amyloid protein: a short review

2001 • 41 citations

Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease

2004 • 40 citations

β3 subunit is present in different nicotinic receptor subtypes in chick retina

2000 • 40 citations

Alzheimer’s and Parkinson’s Disease: Strategies in Research and Development

1986 • 39 citations

Expression of neuronal acetylcholine nicotinic receptor ?4 and ?2 subunits during postnatal development of the rat brain

1995 • 38 citations

Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the α4 subunit of the neuronal nicotinic receptor

2003 • 38 citations

Nicotinic Acetylcholine Receptor Subtypes in the Rat Sympathetic Ganglion: Pharmacological Characterization, Subcellular Distribution and Effect of Pre- and Postganglionic Nerve Crush

2004 • 38 citations

Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

2003 • 38 citations

Postnatal developmental regulation of neuronal nicotinic receptor subunit α7 and multiple α4 and β2 mRNA species in the rat

1998 • 38 citations

Expression of functional nicotinic acetylcholine receptors in neuroepithelial bodies of neonatal hamster lung

2003 • 38 citations

The temporal relation between cigarette smoking and pancreatic cancer.

1983 • 37 citations

Rat arteries contain multiple nicotinic acetylcholine receptor α-subunits

2003 • 35 citations

Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer’s disease

2001 • 35 citations

Keratinocyte acetylcholine receptors regulate cell adhesion

2003 • 35 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. IV. Regulation by external Ca++ of alpha-bungarotoxin-sensitive receptor function and of rectification induced by internal Mg++.

1996 • 35 citations

Cholinergic Stimulation Modulates Apoptosis and Differentiation of Murine Thymocytes via a Nicotinic Effect on Thymic Epithelium

1994 • 34 citations

Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action.

2003 • 32 citations

Developmental Expression of Heteromeric Nicotinic Receptor Subtypes in Chick Retina

2003 • 32 citations

α-Conotoxin imperialis I inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells

1996 • 31 citations

Divergent effects of nicotine administration on cytokine levels in rat small bowel mucosa, colonic mucosa, and blood.

2003 • 31 citations

Pilot trial of nicotine patches as an alternative to corticosteroids in ulcerative colitis

1996 • 29 citations

No association between CHRNA7 microsatellite markers and attention‐deficit hyperactivity disorder

2001 • 29 citations

Chick Optic Lobe Contains a Developmentally Regulated α2α5β2 Nicotinic Receptor Subtype

2000 • 28 citations

Transdermal Nicotine in Tourette’s Syndrome

1995 • 28 citations

Evidence of a functional alpha7-neuronal nicotinic receptor subtype located on motoneurons of the dorsal motor nucleus of the vagus.

2001 • 28 citations

Decline in Response to Nicotine in Aged Rat Striatum: Correlation with a Decrease in a Subpopulation of Nicotinic Receptors

1993 • 27 citations

Effect of chronic nicotine delivery on the proliferation rate of endothelial and smooth muscle cells in experimentally induced vascular wall plaques

1994 • 26 citations

Ciba Foundation Symposium 152 ‐ The Biology of Nicotine Dependence

2007 • 26 citations

Exogenously administered alpha-bungarotoxin binds to embryonic chick spinal cord: Implications for the toxin-induced arrest of naturally occurring motoneuron death

1993 • 25 citations

Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation.

1990 • 25 citations

Relationship Between Tobacco Smoking and Medical Symptoms Among Cocaine‐, Alcohol‐, and Opiate‐Dependent Patients

2002 • 24 citations

Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension.

1994 • 23 citations

Dystrophin Stabilizes α3- But Not α7-Containing Nicotinic Acetylcholine Receptor Subtypes at the Postsynaptic Apparatus in the Mouse Superior Cervical Ganglion

2002 • 23 citations

The benefits of smoking in skin diseases

1998 • 22 citations

Distribution of Cholinergic Neurons in the Mammalian Brain with Special Reference to their Relationship with Neuronal Nicotinic Acetylcholine Receptors

2000 • 22 citations

Cholinergic Stimulation of Human Microcitoma Cell Line H69

1997 • 21 citations

Expression of two neuronal nicotinic receptor subunits in innervated and denervated adult rat muscle

1996 • 21 citations

Spinal Nicotinic Receptor Expression in Spontaneously Hypertensive Rats

1996 • 20 citations

Specific binding of α-bungarotoxin to synaptic membranes in rat sympathetic ganglion: Computer best-fit analysis of electron microscope radioautographs

1983 • 20 citations

Presynaptic Nicotinic Autoreceptors and Heteroreceptors in the CNS

1995 • 18 citations

Nicotinic Neuronal Acetylcholine Receptor α‐3 Subunit Transcription in Normal and Myasthenic Thymusa

1993 • 15 citations

The Effect of Mesalamine and Nicotine in the Treatment of Inflammatory Bowel Disease

1997 • 13 citations

Chronic obstructive pulmonary disease

1991 • 11 citations

Association of the nicotinic receptor beta 2 subunit and febrile seizures

2004 • 10 citations

Selective recovery of striatal 125I-α-conotoxinmii nicotinic receptors after nigrostriatal damage in monkeys

2004 • 9 citations

Distribution of [125I]-α-bungarotoxin binding proteins in fractions from bull spermatozoa

1979 • 9 citations

Mapping of presynaptic nicotinic acetylcholine receptors using fluorescence imaging of neuritic calcium

2003 • 8 citations

Involvement of Neuronal Nicotinic Receptors in Disease

2000 • 7 citations

Growth Related Role for the Nicotinic α-Bungarotoxin Receptor

1995 • 7 citations

Nicotine therapy for ulcerative colitis.

1996 • 7 citations

Agonists and Antagonists of Nicotinic Acetylcholine Receptors

2000 • 5 citations

Neuronal Nicotinic Acetylcholine Receptors in Development and Aging

2000 • 4 citations

Anti-neuronal nicotinic receptor antibodies in MG patients with thymoma

2001 • 4 citations

Neuronal Nicotinic Acetylcholine Receptors in Non-neuronal Cells, Expression and Renaturation of Ligand Binding Domain, and Modulatory Control by Allosterically Acting Ligands

2000 • 3 citations