Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat

1989 • 1,049 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

1995 • 1,017 citations

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor

1986 • 979 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area

1994 • 741 citations

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats

1986 • 693 citations

Nicotinic acetylcholine involvement in cognitive function in animals

1998 • 689 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

1995 • 659 citations

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog

1992 • 553 citations

Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors

1991 • 552 citations

Reduced antinociception in mice lacking neuronal nicotinic receptor subunits

1999 • 546 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

Nicotinic systems and cognitive function

1992 • 519 citations

Mice Deficient in the α7 Neuronal Nicotinic Acetylcholine Receptor Lack α-Bungarotoxin Binding Sites and Hippocampal Fast Nicotinic Currents

1997 • 493 citations

Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice

1996 • 486 citations

Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

1997 • 478 citations

The cholinergic system in Alzheimer's disease

1997 • 399 citations

Nicotinic effects on the firing pattern of midbrain dopamine neurons

1986 • 399 citations

Functional contributions of α5 subunit to neuronal acetylcholine receptor channels

1996 • 389 citations

Identification of four classes of brain nicotinic receptors using beta2 mutant mice.

1998 • 388 citations

Neuronal Nicotinic Receptor a6 Subunit mRNA is Selectively Concentrated in Catecholaminergic Nuclei of the Rat Brain

1996 • 379 citations

Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

1998 • 365 citations

Characterization of Nicotinic Receptor‐Mediated [³H]Dopamine Release from Synaptosomes Prepared from Mouse Striatum

1992 • 352 citations

Assembly of Human Neuronal Nicotinic Receptor α5 Subunits with α3, β2, and β4 Subunits

1996 • 338 citations

Identification of Four Classes of Brain Nicotinic Receptors Using β2 Mutant Mice

1998 • 323 citations

Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats.

1988 • 313 citations

α7 Nicotinic Receptor Subunits Are Not Necessary for Hippocampal-Dependent Learning or Sensorimotor Gating: A Behavioral Characterization of Acra7-Deficient Mice

1998 • 295 citations

Role of α9 Nicotinic ACh Receptor Subunits in the Development and Function of Cochlear Efferent Innervation

1999 • 291 citations

Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor

1999 • 286 citations

Congenital Myasthenic Syndrome Caused by Decreased Agonist Binding Affinity Due to a Mutation in the Acetylcholine Receptor ε Subunit

1996 • 234 citations

Immunological evidence for a change in subunits of the acetylcholine receptor in developing and denervated rat muscle

1988 • 218 citations

Ageing: the cholinergic hypothesis of cognitive decline

1995 • 208 citations

Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors

1999 • 207 citations

The α5 gene product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain

1992 • 205 citations

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release

1994 • 204 citations

Gene transcripts for the nicotinic acetylcholine receptor subunit, beta4, are distributed in multiple areas of the rat central nervous system

1992 • 195 citations

Stimulation of α4β2 nicotinic acetylcholine receptors inhibits β-amyloid toxicity

1998 • 192 citations

A post‐natal decrease in acetylcholine channel open time at rat end‐plates.

1980 • 182 citations

Epibatidine is a nicotinic analgesic

1993 • 168 citations

Congenital Myasthenic Syndromes due to Heteroallelic Nonsense/Missense Mutations in the Acetylcholine Receptor Subunit Gene: Identification and Functional Characterization of Six New Mutations

1997 • 158 citations

Characterization of the antinociception induced by nicotine in the pedunculopontine tegmental nucleus and the nucleus raphe magnus.

1991 • 134 citations

Mice Homozygous for the L250T Mutation in the α7 Nicotinic Acetylcholine Receptor Show Increased Neuronal Apoptosis and Die Within 1 Day of Birth

2000 • 133 citations

Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes.

1998 • 131 citations

Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity

1994 • 112 citations

Acetylcholine receptor ɛ-subunit deletion causes muscle weakness and atrophy in juvenile and adult mice

1996 • 107 citations

A re-examination of the role of basal forebrain cholinergic neurons in spatial working memory

1998 • 107 citations

Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons

1998 • 105 citations

Nerve-dependent modulation of acetylcholine receptor epsilon-subunit gene expression

1991 • 92 citations

Deficient development and maintenance of postsynaptic specializations in mutant mice lacking an ‘adult’ acetylcholine receptor subunit

1997 • 89 citations

Calcium permeability increase of endplate channels in rat muscle during postnatal development.

1996 • 78 citations

Single acetylcholine-activated channel currents in developing muscle cells

1984 • 75 citations

The spinal cord as a major site for the antinociceptive action of nicotine in the rat

1986 • 71 citations

Cerebellar γ-Aminobutyric Acid Type A Receptors: Pharmacological Subtypes Revealed by Mutant Mouse Lines

1997 • 68 citations

Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs

1989 • 59 citations

Impairment of radial-arm maze performance in rats following lesions involving the cholinergic medial pathway: Reversal by arecoline and differential effects of muscarinic and nicotinic antagonists

1991 • 57 citations

Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats.

1991 • 44 citations

Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord

1993 • 15 citations