Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
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References (44)
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 • 6,443 citations
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
1995 • 5,143 citations
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
1994 • 3,249 citations
Disruption of epithelial cell-matrix interactions induces apoptosis
1994 • 3,167 citations
Cancer statistics, 1999
1999 • 3,154 citations
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
1995 • 2,106 citations
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
1998 • 1,963 citations
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998 • 1,180 citations
PKB/Akt
2001 • 1,066 citations
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001 • 981 citations
Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis
2001 • 781 citations
Phosphorylation of the PTEN Tail Regulates Protein Stability and Function
2000 • 756 citations
Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
1988 • 689 citations
α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells
2001 • 671 citations
PKB/AKT: functional insights from genetic models
2001 • 611 citations
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten+/−mice
2001 • 574 citations
Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.
1980 • 456 citations
Nicotinic acetylcholine receptors in health and disease
1997 • 446 citations
α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity
2001 • 414 citations
Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys
1999 • 300 citations
Absorption and metabolism of nicotine from cigarettes.
1975 • 293 citations
Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.
1990 • 288 citations
Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors
1998 • 233 citations
Human Bronchial Epithelial and Endothelial Cells Express α7 Nicotinic Acetylcholine Receptors
2001 • 217 citations
Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells
1998 • 203 citations
Neuronal nicotinic receptors: from protein structure to function
2001 • 186 citations
Activation of Keratinocyte Nicotinic Cholinergic Receptors Stimulates Calcium Influx and Enhances Cell Differentiation
1996 • 158 citations
Molecular Comparison of Human and Mouse Pulmonary Adenocarcinomas
1998 • 154 citations
Role of PI 3-Kinase in Angiopoietin-1-Mediated Migration and Attachment-Dependent Survival of Endothelial Cells
1999 • 135 citations
Molecular Cloning and Mapping of the Human Nicotinic Acetylcholine Receptor α10 (CHRNA10)
2001 • 119 citations
Choline Acetyltransferase, Acetylcholinesterase, and Nicotinic Acetylcholine Receptors of Human Gingival and Esophageal Epithelia
2000 • 118 citations
Long-Term Impact of Smoking on Lung Epithelial Proliferation in Current and Former Smokers
2001 • 101 citations
Peripheral Airway Cell Marker Expression in Non-Small Cell Lung Carcinoma: Association with Distinct Clinicopathologic Features
1992 • 90 citations
Clinical pharmacology of nicotine
1998 • 89 citations
Agonists at the a4b2 Nicotinic Acetylcholine Receptors Relationships and Molecular Modelling
2001 • 89 citations
Up-regulation of human α7 nicotinic receptors by chronic treatment with activator and antagonist ligands
1998 • 77 citations
Characterization of the recombinant human neuronal nicotinic acetylcholine receptors α3β2 and α4β2 stably expressed in HEK293 cells
2000 • 72 citations
Acute Effects of Smoking during Modified Sham Feeding in Duodenal Ulcer Patients: An Analysis of Nicotine, Acid Secretion, Gastrin, Catecholamines, Epidermal Growth Factor, Prostaglandin E2, and Bile Acids
1993 • 67 citations
A study of death by anoikis in cultured epithelial cells
2001 • 66 citations
Pharmacological and physiological properties of a putative ganglionic nicotinic receptor, α3β4, expressed in transfected eucaryotic cells
1995 • 65 citations
Purification and characterization of an alpha-bungarotoxin receptor that forms a functional nicotinic channel.
1991 • 51 citations
Lung Tumorigenicity of NNK Given Orally to A/J Mice: Its Application to Chemopreventive Efficacy Studies
1991 • 37 citations
Cloning and transient expression of genes encoding the human α4 and β2 neuronal nicotinic acetylcholine receptor (nAChR) subunits
1995 • 33 citations
Treatment of Human Cells with N-Nitroso(acetoxymethyl)methylamine: Distribution Patterns of Piperidine-Sensitive DNA Damage at the Nucleotide Level of Resolution Are Related to the Sequence Context
1999 • 22 citations