The genetics of sensory gating deficits in schizophrenia

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Effect of COMT Val ^108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder

2001 • 1,080 citations

Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia

1990 • 1,009 citations

Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia.

1982 • 888 citations

Genetic Variation in the 6p22.3 Gene DTNBP1, the Human Ortholog of the Mouse Dysbindin Gene, Is Associated with Schizophrenia

2002 • 842 citations

Genetic and physiological data implicating the new human gene G72 and the gene for <scp>d</scp> -amino acid oxidase in schizophrenia

2002 • 828 citations

Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia

2001 • 812 citations

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

1993 • 689 citations

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

1995 • 676 citations

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

2001 • 448 citations

Association of Promoter Variants in the α7 Nicotinic Acetylcholine Receptor Subunit Gene With an Inhibitory Deficit Found in Schizophrenia

2002 • 446 citations

Neuropsychopharmacology

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Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics

1992 • 417 citations

Neuroimaging studies of the hippocampus in schizophrenia

2001 • 399 citations

Deficits in Sensory Gating in Schizophrenic Patients and Their Relatives

1984 • 381 citations

Neuropsychological Functioning in Siblings Discordant for Schizophrenia and Healthy Volunteers

1994 • 355 citations

Modulation of the Startle Response and Startle Laterality in Relatives of Schizophrenic Patients and in Subjects With Schizotypal Personality Disorder: Evidence of Inhibitory Deficits

2000 • 352 citations

Decreased protein level of nicotinic receptor α7 subunit in the frontal cortex from schizophrenic brain

1999 • 280 citations

NIMH genetics initiative millennium schizophrenia consortium: Linkage analysis of African-American pedigrees

1998 • 269 citations

Cholinergic gating of response to auditory stimuli in rat hippocampus

1992 • 264 citations

Left Hippocampal Volume as a Vulnerability Indicator for Schizophrenia

2002 • 264 citations

Sensory gating deficits in schizophrenia: new results

1992 • 263 citations

Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia

1999 • 252 citations

A Genome-Wide Scan for Linkage to Chromosomal Regions in 382 Sibling Pairs With Schizophrenia or Schizoaffective Disorder

2002 • 244 citations

Genomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)

1998 • 239 citations

Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia

2002 • 229 citations

Auditory sensory gating in hippocampal neurons: A model system in the rat

1990 • 225 citations

Schizophrenia and Nicotinic Receptors

1994 • 224 citations

Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia

1993 • 213 citations

Gating of auditory P50 in schizophrenics: Unique effects of clozapine

1996 • 203 citations

Genetic Correlation of Inhibitory Gating of Hippocampal Auditory Evoked Response and α-Bungarotoxin-Binding Nicotinic Cholinergic Receptors in Inbred Mouse Strains

1996 • 202 citations

Sensory Gating Deficits Assessed by the P50 Event-Related Potential in Subjects With Schizotypal Personality Disorder

2000 • 200 citations

Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.

1995 • 192 citations

Replication and Extension of P50 Findings in Schizophrenia

1991 • 190 citations

Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the ?7-nicotinic acetylcholine receptor subunit gene (CHRNA7)

2001 • 185 citations

Splitting Schizophrenia: Periodic Catatonia–Susceptibility Locus on Chromosome 15q15

2000 • 185 citations

Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia

2001 • 173 citations

Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium

2001 • 169 citations

P50 Suppression among schizophrenia and normal comparison subjects: A methodological analysis

1997 • 169 citations

Improvement in Smooth Pursuit Eye Movements after Cigarette Smoking in Schizophrenic Patients

1998 • 138 citations

Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative

1998 • 129 citations

Haplotype transmission disequilibrium and evidence for linkage of the CHRNA7 gene region to schizophrenia in Southern African Bantu families

2000 • 127 citations

Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism

2003 • 123 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 121 citations

Effects of P50 temporal variability on sensory gating in schizophrenia

1997 • 114 citations

A 3-Mb Map of a Large Segmental Duplication Overlapping the α7-Nicotinic Acetylcholine Receptor Gene (CHRNA7) at Human 15q13–q14

2002 • 114 citations

Evidence for the multigenic inheritance of schizophrenia

2001 • 110 citations

Nicotinic receptor desensitization and sensory gating deficits in schizophrenia

1998 • 106 citations

Splitting Schizophrenia: Periodic Catatonia–Susceptibility Locus on Chromosome 15q15

2000 • 106 citations

Intragastric DMXB-A, an α7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice

2001 • 105 citations

P50 suppression in recent-onset schizophrenia: Clinical correlates and risperidone effects.

1998 • 96 citations

The −2 bp deletion in exon 6 of the ‘alpha 7-like’ nicotinic receptor subunit gene is a risk factor for the P50 sensory gating deficit

2002 • 95 citations

Evidence for linkage disequilibrium between the alpha 7‐nicotinic receptor gene (CHRNA7) locus and schizophrenia in Azorean families*

2001 • 87 citations

Schizophrenia and smoking: Evidence for a common neurobiological basis?

2000 • 87 citations

The effects of nicotine on specific eye tracking measures in schizophrenia

2002 • 86 citations

Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13–14 in Taiwanese families

2001 • 86 citations

Examination of genetic linkage of chromosome 15 to schizophrenia in a large Veterans Affairs Cooperative Study sample*

2001 • 80 citations

Brief research communication: No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families

1998 • 64 citations

Linkage analysis of schizophrenia to chromosome 15

2001 • 57 citations

The Adenosine Antagonist Theophylline Impairs P50 Auditory Sensory Gating in Normal Subjects

2002 • 43 citations

Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data

2002 • 37 citations

Linkage of strain-specific nicotinic receptor α7 subunit restriction fragment length polymorphisms with levels of α-bungarotoxin binding in brain

1996 • 35 citations

Exclusion of the neuronal nicotinic acetylcholine receptor α7 subunit gene as a candidate for catatonic schizophrenia in a large family supporting the chromosome 15q13–22 locus

2002 • 23 citations

P50 suppression deficits among the relatives of schizophrenia patients

1997 • 6 citations