The Non-neuronal Cholinergic System: an Emerging Drug Target in the Airways

Über humorale übertragbarkeit der Herznervenwirkung

1921 • 817 citations

Mucociliary clearance in the airways.

1996 • 701 citations

Neural control of human airways in health and disease.

1986 • 613 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Vacuolar ATPase activity is required for endosomal carrier vesicle formation.

1994 • 418 citations

Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: Expression and function in humans

1998 • 407 citations

Functional identification of a vesicular acetylcholine transporter and its expression from a “cholinergic” gene locus.

1994 • 383 citations

Extraneuronal cholinergic system in lymphocytes

2000 • 377 citations

Synaptic Vesicles and Exocytosis

1994 • 371 citations

High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis

1979 • 360 citations

Synaptic vesicle biogenesis, docking, and fusion: a molecular description

1996 • 349 citations

Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea‐pig

1984 • 318 citations

Regulation of Tracheobronchial Smooth Muscle

1963 • 302 citations

THE CHOLINERGIC ‘PITFALL’: ACETYLCHOLINE, A UNIVERSAL CELL MOLECULE IN BIOLOGICAL SYSTEMS, INCLUDING HUMANS

1999 • 292 citations

Quantal acetylcholine release at the vertebrate neuromuscular junction.

1994 • 277 citations

Nerve supply to the lungs.

1979 • 271 citations

Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man

1997 • 270 citations

Human Keratinocytes Synthesize, Secrete, and Degrade Acetylcholine

1993 • 268 citations

CHOLINESTERASES IN THE BLOOD OF MAN

1940 • 256 citations

Muscarinic receptor subtypes in airways

1993 • 254 citations

Modulation of neurotransmission in airways

1992 • 247 citations

Biological Functions of Keratinocyte Cholinergic Receptors

1997 • 244 citations

Human vascular endothelial cells express functional nicotinic acetylcholine receptors.

1998 • 240 citations

Human and Rodent Bronchial Epithelial Cells Express Functional Nicotinic Acetylcholine Receptors

1998 • 233 citations

Cholinergic systems in non-nervous tissues.

1978 • 206 citations

Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain

1985 • 204 citations

The Cholinergic Gene Locus

1998 • 201 citations

Asthma : basic mechanisms and clinical management

1992 • 199 citations

The exocytotic fusion pore.

1992 • 195 citations

The Non-neuronal Cholinergic System

2001 • 186 citations

Pharmacological characterization of the acetylcholine transport system in purified Torpedo electric organ synaptic vesicles.

1983 • 181 citations

A unique gene organization for two cholinergic markers, choline acetyltransferase and a putative vesicular transporter of acetylcholine.

1994 • 179 citations

Parainfluenza virus infection damages inhibitory M₂ muscarinic receptors on pulmonary parasympathetic nerves in the guinea‐pig

1991 • 176 citations

Reflex effects of upper airway irritation on total lung resistance and blood pressure

1962 • 172 citations

Choline Acetyltransferase: Celebrating Its Fiftieth Year

1994 • 167 citations

The vesicular acetylcholine transport system

1987 • 167 citations

Activation of Keratinocyte Nicotinic Cholinergic Receptors Stimulates Calcium Influx and Enhances Cell Differentiation

1996 • 158 citations

Augmented acetylcholine‐induced, Rho‐mediated Ca²⁺ sensitization of bronchial smooth muscle contraction in antigen‐induced airway hyperresponsive rats

1999 • 145 citations

The exocytotic fusion pore and neurotransmitter release

1994 • 140 citations

Localization of Muscarinic Receptor Subtype mRNAs in Human Lung

1992 • 136 citations

Coregulation of Two Embedded Gene Products, Choline Acetyltransferase and the Vesicular Acetylcholine Transporter

1995 • 133 citations

Active transport of Na+ and Cl- across the canine tracheal epithelium in vitro.

1975 • 133 citations

Neuroendocrine cells and nerves of the lung

1993 • 129 citations

Cholinergic Augmentation of Lymphocyte-Mediated Cytotoxicity. A Study of the Cholinergic Receptor of Cytotoxic T Lymphocytes

1974 • 122 citations

Microtubule-Dependent Vesicle Transport: Modulation of Channel and Transporter Activity in Liver and Kidney

1998 • 120 citations

Release of non‐neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters

2001 • 118 citations

Immunoregulatory role of neurotransmitters

1996 • 117 citations

Inhibition of Muscarinic Receptor‐Stimulated Glial Cell Proliferation by Ethanol

1996 • 113 citations

Flash photolysis of caged inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells.

1993 • 112 citations

Localization and synthesis of acetylcholine in human leukemic T cell lines

1996 • 103 citations

Neural Mechanisms in Asthma

1991 • 103 citations

Regulation of Cl⁻ and K⁺ Channels in Airway Epithelium

1990 • 103 citations

Changes in cytosolic Ca2+ and contraction induced by various stimulants and relaxants in canine tracheal smooth muscle

1990 • 100 citations

Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator

1998 • 98 citations

Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma.

1993 • 91 citations

Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes

1998 • 89 citations

Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity

1995 • 88 citations

Acetylcholine and ciliary movement in the gill plates of Mytilus edulis

1953 • 87 citations

Cholinergic receptors of lymphocytes

1989 • 84 citations

Neural mechanisms in asthma

1992 • 84 citations

Keratinocyte Muscarinic Acetylcholine Receptors: Immunolocalization and Partial Characterization

1995 • 83 citations

Choline Acetyltransferase and the Synthesis of Acetylcholine

1988 • 80 citations

Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes

1996 • 72 citations

Muscarinic receptor subtypes mediating vasodilation in the pulmonary artery

1988 • 69 citations

Stimulation of ciliary beat frequency by autonomic agonists: in vivo

1988 • 67 citations

Agarose Gel Keratinocyte Outgrowth System as a Model of Skin Re-epithelization: Requirement of Endogenous Acetylcholine for Outgrowth Initiation

1993 • 66 citations

The synaptic vesicle and its targets

1995 • 66 citations

Mechanisms of mitogen-activated protein kinase activation by nicotine in small-cell lung carcinoma cells

1997 • 66 citations

Physiologic responses and histamine release after nasal antigen challenge. Effect of atropine.

1994 • 64 citations

Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral α2-receptors

1995 • 60 citations

Cholinergic activation of Cl− secretion in rat colonic epithelia

1995 • 60 citations

Continuous in vivo treatment with catecholamines suppresses in vitro reactivity of rat peripheral blood T-lymphocytes via α-mediated mechanisms

1992 • 59 citations

Regulation of ciliary beat frequency by autonomic mechanisms: in vitro

1988 • 58 citations

ACETYLCHOLINE IN NORMAL AND DISEASED SKIN.

1962 • 58 citations

The effects of epithelium removal on the actions of cholinomimetic drugs in opened segments and perfused tubular preparations of guinea‐pig trachea

1990 • 55 citations

Activation of nicotinic acetylcholine receptors increases the rate of fusion of cultured human myoblasts.

1995 • 54 citations

Metachronal activity of cultured mucociliary epithelium under normal and stimulated conditions

1994 • 53 citations

Regulation of sodium absorption by canine tracheal epithelium.

1987 • 53 citations

Acetylcholine via Muscarinic Receptors Inhibits Histamine Release from Human Isolated Bronchi

1997 • 51 citations

The parasympathetic nervous system takes part in the immuno-neuroendocrine dialogue

1991 • 51 citations

Muscarinic Control of Histamine Release from Airways

2000 • 50 citations

Expression of Choline Acetyltransferase mRNA and Protein in T-Lymphocytes.

1995 • 50 citations

A cholinergic receptor site on murine lymphocytes with novel binding characteristics

1984 • 50 citations

Phorbol ester stimulates acetylcholine synthesis in cultured endothelial cells isolated from porcine cerebral microvessels

1994 • 49 citations

Glucocorticoids mediate reduction of epithelial acetylcholine content in the airways of rats and humans

1998 • 49 citations

M3 Muscarinic Acetylcholine Receptors Regulate Cytoplasmic Myosin by a Process Involving RhoA and Requiring Conventional Protein Kinase C Isoforms

1999 • 47 citations

Neural and non-neural acetylcholine in the rat diaphragm

1982 • 47 citations

Expression of the cholinergic gene locus in pulmonary arterial endothelial cells

2000 • 46 citations

Über den Nachweis von Hormonen in einzelligen Tieren

1936 • 44 citations

The synthesis and release of acetylcholine in normal and denervated rat diaphragms during incubation in vitro

1983 • 44 citations

Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells

1998 • 44 citations

Synthesis of acetylcholine by endothelial cells isolated from rat brain cortex capillaries

1987 • 44 citations

Evidence for a M₁ muscarinic receptor on the endothelium of human pulmonary veins

2000 • 43 citations

Muscarinic cholinergic binding sites on rat lymphocytes

1988 • 42 citations

The keratinocyte cholinergic system with acetylcholine as an epidermal cytotransmitter

1997 • 39 citations

Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity

1992 • 39 citations

Effect of acetyl choline on ion transport in sheep tracheal epithelium

1994 • 37 citations

Muscarinic Receptor Subtypes in Lung: Clinical Implications

1990 • 33 citations

Response of lymphocyte guanyl cyclase to propranolol, noradrenaline, thymoxamine, and acetylcholine in extrinsic bronchial asthma.

1975 • 32 citations

Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor.

1995 • 30 citations

Intact human lymphocyte membranes respond to muscarinic receptor stimulation by oxotremorine with marked changes in microviscosity and an increase in cyclic GMP

1985 • 26 citations

Nasal glandular secretory response to cholinergic stimulation in humans and guinea pigs

1991 • 25 citations

The High-Affinity Choline Uptake System

1988 • 25 citations

Transient cholinergic glycoconjugate secretion from swine tracheal submucosal gland cells

1992 • 24 citations

Regulation of acetylcholine hydrolysis in canine tracheal smooth muscle

1991 • 23 citations

Chapter 17 Muscarinic receptors and cell signalling

1996 • 21 citations

Capsaicin-activated bronchial- and alveolar-initiated pathways regulating tracheal ciliary beat frequency

1994 • 20 citations

Effects of quaternary ammonium compounds on choline entry into the rat diaphragm muscle fibre

1972 • 19 citations

Update: pharmacology of airway secretion.

1994 • 18 citations

Muscarinic receptor subtypes in lung

1992 • 17 citations

Muscarinic Receptors in Airways Diseases

2001 • 13 citations

Muscarinic receptors of the vascular bed: radioligand binding studies on bovine splenic veins.

1986 • 13 citations

Evidence for muscarinic receptors in endothelial cells from combined functional and binding studies

1990 • 12 citations

Increased secretion of glandular‐kallikrein in the bronchial washings induced by intravenous injection of leukotriene C₄ in guinea‐pigs

1992 • 11 citations

Role of non-neuronal and neuronal acetylcholine in the airways

2001 • 9 citations

Histamine-Induced Increase in Isometric Tension of Smooth Muscle Is Mediated by Local Vagus Nerve in Human Bronchus

2000 • 8 citations

Chapter 18 Muscarinic receptor activated Ca2+channels in non-excitable cells

1996 • 7 citations