Nicotinic α7 receptors: Synaptic options and downstream signaling in neurons

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

Presynaptic nicotinic ACh receptors

1997 • 1,313 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

Cholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones

1954 • 1,172 citations

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

2000 • 1,086 citations

The Diversity of Neuronal Nicotinic Acetylcholine Receptors

1993 • 1,040 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Vesicle Pools and Ca2+ Microdomains: New Tools for Understanding Their Roles in Neurotransmitter Release

1998 • 1,021 citations

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

1996 • 955 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Signaling to the Nucleus by an L-type Calcium Channel-Calmodulin Complex Through the MAP Kinase Pathway

2001 • 908 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

1996 • 881 citations

Nicotinic Receptors in the Development and Modulation of CNS Synapses

1996 • 771 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1996 • 735 citations

EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

2000 • 702 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

PDZ Domains: Structural Modules for Protein Complex Assembly

2002 • 696 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Cholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: A combined light and electron microscopic study

1985 • 594 citations

Competitive binding of α-actinin and calmodulin to the NMDA receptor

1997 • 591 citations

Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.

1993 • 543 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice

1995 • 530 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Calcium-induced actin depolymerization reduces NMDA channel activity

1993 • 510 citations

Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily

1990 • 471 citations

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

1999 • 462 citations

Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system

1983 • 461 citations

Synaptic Clustering of AMPA Receptors by the Extracellular Immediate-Early Gene Product Narp

1999 • 457 citations

Nicotinic receptors in the brain: correlating physiology with function

1999 • 450 citations

Choline is a Selective Agonist of α7 Nicotinic Acetylcholine Receptors in the Rat Brain Neurons

1997 • 443 citations

α7 Nicotinic Receptor Transduces Signals to Phosphatidylinositol 3-Kinase to Block A β-Amyloid-induced Neurotoxicity

2001 • 414 citations

Diffuse transmission by acetylcholine in the CNS

1997 • 407 citations

Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

1993 • 394 citations

Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor.

1993 • 389 citations

Neuronal Nicotinic Acetylcholine Receptors

1996 • 377 citations

Ultrastructural Distribution of the α7 Nicotinic Acetylcholine Receptor Subunit in Rat Hippocampus

2001 • 358 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Volume transmission in the CNS and its relevance for neuropsychopharmacology

1999 • 334 citations

Synaptic Potentials Mediated via α-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons

1998 • 334 citations

Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices.

1997 • 330 citations

Calcium regulation of gene expression in neuronal cells

1994 • 327 citations

Neurons assemble acetylcholine receptors with as many as three kinds of subunits while maintaining subunit segregation among receptor subtypes

1993 • 303 citations

Ca2+-dependent regulation in neuronal gene expression

1997 • 290 citations

Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors

1998 • 280 citations

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.

1999 • 279 citations

An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype

1996 • 278 citations

Single calcium channels and acetylcholine release at a presynaptic nerve terminal

1993 • 266 citations

α-Bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices

1998 • 263 citations

Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus

1993 • 255 citations

Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels

1994 • 254 citations

The C.elegansric-3 gene is required for maturation of nicotinic acetylcholine receptors

2002 • 241 citations

Interactions of Calmodulin and α-Actinin with the NR1 Subunit Modulate Ca²⁺-Dependent Inactivation of NMDA Receptors

1999 • 228 citations

α-Bungarotoxin-Sensitive Nicotinic Receptors Indirectly Modulate [³H]Dopamine Release in Rat Striatal Slices via Glutamate Release

2000 • 220 citations

Neuronal α-Bungarotoxin Receptors Are α7 Subunit Homomers

2000 • 214 citations

The ultrastructural localization of alpha-bungarotoxin binding sites in relation to synapses on chick ciliary ganglion neurons

1983 • 208 citations

Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels

2002 • 207 citations

Ca2+ channel-regulated neuronal gene expression

1998 • 204 citations

The α-Bungarotoxin-binding Nicotinic Acetylcholine Receptor from Rat Brain Contains Only the α7 Subunit

1997 • 200 citations

Critical Dependence of cAMP Response Element-Binding Protein Phosphorylation on L-Type Calcium Channels Supports a Selective Response to EPSPs in Preference to Action Potentials

2000 • 195 citations

Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons.

2001 • 195 citations

Fast Synaptic Signaling by Nicotinic Acetylcholine and Serotonin 5-HT₃Receptors in Developing Visual Cortex

1997 • 194 citations

NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex

2002 • 189 citations

Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin

1996 • 189 citations

Membrane Lipid Rafts Are Necessary for the Maintenance of the α7 Nicotinic Acetylcholine Receptor in Somatic Spines of Ciliary Neurons

2001 • 172 citations

L-Type Ca²⁺Channels Are Essential for Glutamate-Mediated CREB Phosphorylation andc-fosGene Expression in Striatal Neurons

1999 • 168 citations

Voltage-Gated Channels Block Nicotinic Regulation of CREB Phosphorylation and Gene Expression in Neurons

2001 • 157 citations

Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices

1999 • 156 citations

Two distantly positioned PDZ domains mediate multivalent INAD-phospholipase C interactions essential for G protein-coupled signaling

1998 • 156 citations

The Chaperone Protein 14-3-3η Interacts with the Nicotinic Acetylcholine Receptor α4 Subunit

2001 • 155 citations

Functional contribution of the α7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones

1998 • 152 citations

Cholinergic Modulation of Excitatory Synaptic Transmission in the CA3 Area of the Hippocampus

2001 • 150 citations

Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons

2002 • 150 citations

PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity

2001 • 145 citations

Gene regulation by patterned electrical activity during neural and skeletal muscle development

1999 • 144 citations

Nicotinic α7 Receptor Clusters on Hippocampal GABAergic Neurons: Regulation by Synaptic Activity and Neurotrophins

2002 • 142 citations

Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: synaptic pattern and age-related atrophy

2001 • 138 citations

Shared antigenic determinant between the Electrophorus acetylcholine receptor and a synaptic component on chicken ciliary ganglion neurons.

1984 • 136 citations

Rundown of N‐methyl‐D‐aspartate channels during whole‐cell recording in rat hippocampal neurons: role of Ca2+ and ATP.

1993 • 135 citations

The long internal loop of the α3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo

1998 • 134 citations

Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion

1995 • 129 citations

The Inhibitory Effects of Omega‐Conotoxins on Ca Channels and Synapses^a

1989 • 125 citations

Rapid Synaptic Transmission in the Avian Ciliary Ganglion Is Mediated by Two Distinct Classes of Nicotinic Receptors

1997 • 121 citations

Nicotinic Regulation of CREB Activation in Hippocampal Neurons by Glutamatergic and Nonglutamatergic Pathways

2002 • 118 citations

Src-Class Kinases Act within the Agrin/MuSK Pathway to Regulate Acetylcholine Receptor Phosphorylation, Cytoskeletal Anchoring, and Clustering

2001 • 115 citations

Ultrastructural Localization of the α4-Subunit of the Neuronal Acetylcholine Nicotinic Receptor in the Rat Substantia Nigra

1999 • 112 citations

Distributions of nicotinic acetylcholine receptor α7 and β2 subunits on cultured hippocampal neurons

1999 • 112 citations

Ultrastructural distribution of 125I-toxin F binding sites on chick ciliary neurons: synaptic localization of a toxin that blocks ganglionic nicotinic receptors

1987 • 110 citations

Nicotinic Receptor Subtypes in the Developing Chick Brain: Appearance of a Species Containing the α4, β2, and α5 Gene Products

1998 • 110 citations

Neuronal Acetylcholine Receptors with α7 Subunits Are Concentrated on Somatic Spines for Synaptic Signaling in Embryonic Chick Ciliary Ganglia

1999 • 108 citations

Mammalian Nicotinic Receptors with α7 Subunits That Slowly Desensitize and Rapidly Recover from α-Bungarotoxin Blockade

1998 • 107 citations

Genes to remember

1999 • 101 citations

Signaling Cascade Regulating Long-Term Potentiation of GABA_AReceptor Responsiveness in Cerebellar Purkinje Neurons

2002 • 100 citations

Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus

2001 • 94 citations

α7 Nicotinic Acetylcholine Receptors Occur at Postsynaptic Densities of AMPA Receptor-Positive and -Negative Excitatory Synapses in Rat Sensory Cortex

2002 • 91 citations

Rapid Regulation of Brain-Derived Neurotrophic Factor mRNA within Eye-Specific Circuits during Ocular Dominance Column Formation

2000 • 91 citations

Localization of α-bungarotoxin binding sites in the ciliary ganglion of the embryonic chick: An autoradiographic study at the light and electron microscopic level

1985 • 90 citations

Nicotinic receptor activation facilitates gabaergic neurotransmission in the avian lateral spiriform nucleus

1994 • 89 citations

Agrin-induced Activation of Acetylcholine Receptor-bound Src Family Kinases Requires Rapsyn and Correlates with Acetylcholine Receptor Clustering

2001 • 85 citations

Two distinct classes of functional α7‐containing nicotinic receptor on rat superior cervical ganglion neurons

2000 • 85 citations

Nicotinic acetylcholine currents in cultured postnatal rat hippocampal neurons.

1992 • 84 citations

Clustering of Nicotinic Acetylcholine Receptors: From the Neuromuscular Junction to Interneuronal Synapses

2002 • 83 citations

Synaptically Driven Calcium Transients via Nicotinic Receptors on Somatic Spines

2001 • 80 citations

The Effects of Acute Nicotine on the Metabolism of Dopamine and the Expression of Fos Protein in Striatal and Limbic Brain Areas of Rats during Chronic Nicotine Infusion and Its Withdrawal

1999 • 79 citations

Functional development of the parasympathetic neurons of the avian ciliary ganglion: A classic model system for the study of neuronal differentiation and development

1994 • 77 citations

Direct recording of nicotinic responses in presynaptic nerve terminals.

1997 • 76 citations

Cytoskeletal Links of Neuronal Acetylcholine Receptors Containing α7 Subunits

2000 • 67 citations

Direct Recording of Nicotinic Responses in Presynaptic Nerve Terminals

1997 • 67 citations

Actin Filaments and the Opposing Actions of CaM Kinase II and Calcineurin in Regulating α7-Containing Nicotinic Receptors on Chick Ciliary Ganglion Neurons

1999 • 63 citations

Rapsyn Clusters Neuronal Acetylcholine Receptors But Is Inessential for Formation of an Interneuronal Cholinergic Synapse

1998 • 57 citations

Nicotinic cholinoceptor-mediated excitatory postsynaptic potentials in rat nucleus ambiguus

1993 • 57 citations

The hypothesis of an ambient level of acetylcholine in the central nervous system

1998 • 56 citations

Involvement of α7 Nicotinic Acetylcholine Receptors in Activation of Tyrosine Hydroxylase and Dopamine β‐Hydroxylase Gene Expression in PC12 Cells

2000 • 55 citations

Ultrastructure of a Somatic Spine Mat for Nicotinic Signaling in Neurons

2002 • 53 citations

Phosphorylation and Cytoskeletal Anchoring of the Acetylcholine Receptor by Src Class Protein-tyrosine Kinases

1999 • 52 citations

Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal

2000 • 49 citations

Effects of synaptic and antidromic stimulation on tyrosine hydroxylase activity in the rat superior cervical ganglion.

1980 • 47 citations

Chick Ciliary Ganglion Neurons Contain Transcripts Coding for Acetylcholine Receptor-Associated Protein at Synapses (Rapsyn)

1997 • 34 citations

Neuronal regulation of c-fos, c-jun, and junB immediate-early genes in rat adrenal medulla

1995 • 33 citations

Properties of Nicotinic Receptors Underlying Renshaw Cell Excitation by α-Motor Neurons in Neonatal Rat Spinal Cord

2002 • 33 citations

Expression and localization of agrin during sympathetic synapse formation in vitro

2001 • 32 citations

Experssion of α-Bungarotoxin Receptro Subtypes in Chick Central Nervous System During Development

1994 • 24 citations

Phosphotyrosine phosphatase activity associated with c-Src in large multimeric complexes isolated from adrenal medullary chromaffin cells

1997 • 21 citations

Rapsyn Variants in Ciliary Ganglia and Their Possible Effects on Clustering of Nicotinic Receptors

1999 • 18 citations

Cytoskeletal interactions with glutamate receptors at central synapses.

1997 • 15 citations