The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

The Structure of Haplotype Blocks in the Human Genome

2002 • 5,744 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 • 3,923 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Prevalence of Diabetes, Impaired Fasting Glucose, and Impaired Glucose Tolerance in U.S. Adults: The Third National Health and Nutrition Examination Survey, 1988–1994

1998 • 2,780 citations

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

1996 • 2,667 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

2003 • 2,181 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2001 • 1,831 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

2001 • 1,782 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

A comprehensive review of genetic association studies

2002 • 1,697 citations

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

1996 • 1,607 citations

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

2000 • 1,487 citations

Association study designs for complex diseases

2001 • 1,415 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Haplotype tagging for the identification of common disease genes

2001 • 1,188 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young

2001 • 1,127 citations

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1997 • 1,125 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

1992 • 1,103 citations

Candidate-gene approaches for studying complex genetic traits: practical considerations

2002 • 1,071 citations

Diabetes in identical twins

1981 • 965 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy

1995 • 812 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

HL-A ANTIGENS AND DIABETES MELLITUS

1974 • 802 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes

2003 • 745 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Familial Hyperglycemia Due to Mutations in Glucokinase -- Definition of a Subtype of Diabetes Mellitus

1993 • 737 citations

Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13

2001 • 714 citations

LMNA, encoding lamin A/C, is mutated in partial lipodystrophy

2000 • 688 citations

Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome 3q27-qter and Independent Replication of a Type 2–Diabetes Locus on Chromosome 1q21–q24

2000 • 686 citations

Nuclear lamin A/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy

2000 • 656 citations

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome

2000 • 638 citations

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Heritability of Type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance - a population-based twin study

1999 • 611 citations

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

1999 • 610 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome

1995 • 596 citations

Sequence of the human insulin gene

1980 • 553 citations

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

2000 • 525 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Concordance for Type 2 (non-insulin-dependent) diabetes mellitus in male twins

1987 • 519 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34

2002 • 503 citations

An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians

1998 • 484 citations

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1995 • 456 citations

Histocompatibility (HL-A) Antigens, Lymphocytotoxic Antibodies and Tissue Antibodies in Patients with Diabetes Mellitus

1973 • 409 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves’ Disease and to Type 1 Diabetes Mellitus¹

1997 • 408 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

1999 • 386 citations

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

2002 • 365 citations

Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins

1995 • 357 citations

Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans

1999 • 340 citations

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

1998 • 340 citations

Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Pima Diabetes Genes Group.

1998 • 332 citations

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

1996 • 330 citations

A search for type 1 diabetes susceptibility genes in families from the United Kingdom

1998 • 329 citations

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele

2001 • 323 citations

A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians.

1999 • 309 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

A Genomewide Scan for Loci Predisposing to Type 2 Diabetes in a U.K. Population (The Diabetes UK Warren 2 Repository): Analysis of 573 Pedigrees Provides Independent Replication of a Susceptibility Locus on Chromosome 1q

2001 • 307 citations

Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus

2001 • 296 citations

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

2000 • 295 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

The E23K Variant of Kir6.2 Associates With Impaired Post-OGTT Serum Insulin Response and Increased Risk of Type 2 Diabetes

2003 • 286 citations

Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.

1991 • 277 citations

The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

2000 • 274 citations

Missense mutations in the pancreatic islet beta cell inwardly rectifying K + channel gene (KIR6.2/BIR ): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

1998 • 271 citations

CTLA4 Alanine-17 Confers Genetic Susceptibility to Graves' Disease and to Type 1 Diabetes Mellitus

1997 • 270 citations

Seven Regions of the Genome Show Evidence of Linkage to Type 1 Diabetes in a Consensus Analysis of 767 Multiplex Families

2001 • 264 citations

Maturity-Onset Diabetes of Youth in Black Americans

1987 • 262 citations

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

1989 • 260 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

2002 • 246 citations

KIR6.2 Polymorphism Predisposes to Type 2 Diabetes by Inducing Overactivity of Pancreatic β-Cell ATP-Sensitive K+ Channels

2002 • 244 citations

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population

2001 • 241 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

Parameters for reliable results in genetic association studies in common disease

2002 • 237 citations

The Finland–United States Investigation of Non–Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome Scan for Genes That Predispose to Type 2 Diabetes

2000 • 233 citations

HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus

1981 • 231 citations

Testing for Population Subdivision and Association in Four Case-Control Studies

2002 • 226 citations

Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

1999 • 220 citations

Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy

1997 • 214 citations

Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33

1995 • 211 citations

Genomewide Search for Type 2 Diabetes Susceptibility Genes in Four American Populations

2000 • 195 citations

A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q

1995 • 193 citations

Studies of Association between the Gene for Calpain-10 and Type 2 Diabetes Mellitus in the United Kingdom

2001 • 191 citations

Once and Again—Issues Surrounding Replication in Genetic Association Studies

2002 • 182 citations

Genetics of Type 1A Diabetes

2001 • 179 citations

Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

2000 • 177 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Association studies of variants in promoter and coding regions of beta‐cell ATP‐sensitive K‐channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)

2001 • 172 citations

A missense mutation in the glucagon receptor gene is associated with non–insulin–dependent diabetes mellitus

1995 • 171 citations

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene

1997 • 168 citations

Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.

1999 • 167 citations

Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes Mellitus

1999 • 157 citations

Detection of an Alteration in the Insulin-Receptor Gene in a Patient with Insulin Resistance, Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)

1988 • 153 citations

The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)

2002 • 149 citations

Genetic Variation in the Human Insulin Gene

1980 • 145 citations

New susceptibility locus for NIDDM is localized to human chromosome 20q

1997 • 143 citations

CTLA4 Gene Polymorphism Confers Susceptibility to Graves' Disease in Japanese

1997 • 139 citations

Tolbutamide-induced Improvement in Carbohydrate Tolerance of Young People with Mild Diabetes Mellitus

1960 • 138 citations

Genomewide Search for Type 2 Diabetes Mellitus Susceptibility Loci in Finnish Families: The Botnia Study

2002 • 138 citations

A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population

2001 • 137 citations

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes

2000 • 137 citations

HL-A ANTIGENS AND DIABETES MELLITUS

1974 • 135 citations

Sequence Variants in the Sulfonylurea Receptor (SUR) Gene Are Associated With NIDDM in Caucasians

1996 • 134 citations

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant

2001 • 133 citations

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8

1996 • 129 citations

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white caucasian subjects or evidence of abnormal function when expressed in vitro

1996 • 124 citations

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

1998 • 122 citations

Geographic and Haplotype Structure of Candidate Type 2 Diabetes-Susceptibility Variants at the Calpain-10 Locus

2002 • 122 citations

A genome-wide search for Type II diabetes susceptibility genes in Chinese Hans

2001 • 117 citations

Gene dosage and susceptibility to insulin‐dependent diabetes

1980 • 117 citations

Genetic linkage and association studies of Type I diabetes: challenges and rewards

2002 • 116 citations

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

2000 • 113 citations

Genetic epidemiology of type 1 diabetes

2003 • 112 citations

Role of Hemochromatosis C282Y and H63D Mutations in HFE Gene in Development of Type 2 Diabetes and Diabetic Nephropathy

2001 • 109 citations

Lower-Than-Expected Linkage Disequilibrium between Tightly Linked Markers in Humans Suggests a Role for Gene Conversion

2001 • 107 citations

Sequence Variants in the Pancreatic Islet β-Cell Inwardly Rectifying K+ Channel Kir6.2 (Bir) Gene: Identification and Lack of Role in Caucasian Patients with NIDDM

1997 • 106 citations

Significance of Pro12Ala Mutation in Peroxisome Proliferator-Activated Receptor-γ2 in Korean Diabetic and Obese Subjects*

2000 • 102 citations

Type 2 Diabetes and Three Calpain-10 Gene Polymorphisms in Samoans: No Evidence of Association

2001 • 100 citations

Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11

1985 • 100 citations

Susceptibility to Insulin-Dependent Diabetes Mellitus Maps to a Locus (IDDM11) on Human Chromosome 14q24.3–q31

1996 • 99 citations

A Gene Conferring Susceptibility to Type 2 Diabetes in Conjunction With Obesity Is Located on Chromosome 18p11

2001 • 98 citations

Genetic Studies of the Sulfonylurea Receptor Gene Locus in NIDDM and in Morbid Obesity Among French Caucasians

1997 • 97 citations

HLA Genotypic Study of Insulin-dependent Diabetes: The Excess of DR3/DR4 Heterozygotes Allows Rejection of the Recessive Hypothesis

1983 • 97 citations

The Finland–United States Investigation of Non–Insulin‐Dependent Diabetes Mellitus Genetics (FUSION) Study. I. An Autosomal Genome Scan for Genes That Predispose to Type 2 Diabetes

2000 • 94 citations

Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.

1997 • 93 citations

Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin.

2000 • 91 citations

A Genomewide Search for Type 2 Diabetes–Susceptibility Genes in Indigenous Australians

2002 • 89 citations

Role of Calpain-10 Gene Variants in Familial Type 2 Diabetes in Caucasians

2002 • 87 citations

Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians

1999 • 87 citations

Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes

2001 • 86 citations

Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians

2002 • 86 citations

A human proinsulin variant at arginine 65

1981 • 84 citations

Effect of the Peroxisome Proliferator-Activated Receptor-γ2 Pro¹²Ala Variant on Obesity, Glucose Homeostasis, and Blood Pressure in Members of Familial Type 2 Diabetic Kindreds¹

2001 • 83 citations

Peroxisome Proliferator-Activated Receptor-γ2 P12A and Type 2 Diabetes in Canadian Oji-Cree*

2000 • 81 citations

Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population

2002 • 81 citations

Variation in the Calpain-10 Gene Affects Blood Glucose Levels in the British Population

2002 • 80 citations

Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

2002 • 80 citations

Variants Within the Calpain-10 Gene on Chromosome 2q37 (NIDDM1) and Relationships to Type 2 Diabetes, Insulin Resistance, and Impaired Acute Insulin Secretion Among Scandinavian Caucasians

2002 • 78 citations

Amino Acid Polymorphisms in the ATP-Regulatable Inward Rectifier Kir6.2 and Their Relationships to Glucose- and Tolbutamide-Induced Insulin Secretion, the Insulin Sensitivity Index, and NIDDM

1997 • 76 citations

Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q.

1998 • 73 citations

Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort

2002 • 71 citations

Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 With Several Autoimmune Diseases

2001 • 69 citations

CLOSE GENETIC LINKAGE BETWEEN DIABETES MELLITUS AND KIDD BLOOD GROUP

1981 • 67 citations

Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese

2002 • 66 citations

Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11

1997 • 65 citations

ASSOCIATION OF GENETIC VARIANT OF THE GLUCOSE TRANSPORTER WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS

1988 • 63 citations

Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulin.

1983 • 63 citations

A Genome-Wide Scan for Obesity in African-Americans

2002 • 61 citations

Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family.

1998 • 59 citations

Fine Mapping of the Diabetes-Susceptibility Locus, on Chromosome 11q13

1998 • 58 citations

Peroxisome proliferator—activated receptor gamma 2 pro12ala gene variant is strongly associated with larger body mass in the Taiwanese

2000 • 56 citations

A genetic marker at the glucokinase gene locus for Type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles

1992 • 50 citations

Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: prospective cohort study

2000 • 47 citations

Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q.

1999 • 45 citations

Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: A population study

2001 • 43 citations

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.

1998 • 41 citations

Effect of the Peroxisome Proliferator-Activated Receptor- 2 Pro12Ala Variant on Obesity, Glucose Homeostasis, and Blood Pressure in Members of Familial Type 2 Diabetic Kindreds

2001 • 40 citations

Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations

1996 • 38 citations

Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery.

1998 • 37 citations

Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect?

1995 • 36 citations

Significance of Pro12Ala Mutation in Peroxisome Proliferator-Activated Receptor- 2 in Korean Diabetic and Obese Subjects

2000 • 34 citations

HepG2/erythrocyte glucose transporter (GLUT1) gene in NIDDM: a population association study and molecular scanning in Japanese subjects

1995 • 32 citations

Linkage of type I diabetes to 15q26 (IDDM3) in the Danish population

1996 • 30 citations

Peroxisome Proliferator-Activated Receptor- 2 P12A and Type 2 Diabetes in Canadian Oji-Cree

2000 • 29 citations

Is a Pro12Ala Polymorphism of the PPARγ2 Gene Related to Obesity and Type 2 Diabetes Mellitus in the Czech Population?

2002 • 29 citations

Fine-mapping of the type 1 diabetes locus ( IDDM4 ) on chromosome 11q and evaluation of two candidate genes ( FADD and GALN ) by affected sibpair and linkage-disequilibrium analyses

2000 • 28 citations

Identification of Genetic Markers Flanking the Locus for Maturity-Onset Diabetes of the Young on Human Chromosome 20

1992 • 25 citations

Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans.

2000 • 25 citations

Linkage Analysis of GLUT1 (HepG2) and GLUT2 (Liver/Islet) Genes in Familial NIDDM

1992 • 23 citations

Glucokinase Gene Polymorphisms: a Genetic Marker for Glucose Intolerance in a Cohort of Elderly Finnish Men

1994 • 20 citations

The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.

1996 • 9 citations

Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population

1994 • 7 citations