A comprehensive review of genetic association studies

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Genomic Control for Association Studies

1999 • 3,132 citations

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

2001 • 2,948 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Association Mapping in Structured Populations

2000 • 1,990 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

Association study designs for complex diseases

2001 • 1,415 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies

1999 • 1,226 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.

1997 • 796 citations

The <EMPH TYPE="ITAL">APOE</EMPH>-∊4 Allele and the Risk of Alzheimer Disease Among African Americans, Whites, and Hispanics

1998 • 741 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Population genetics—making sense out of sequence

1999 • 641 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

1999 • 542 citations

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

1996 • 496 citations

Detecting association in a case-control study while correcting for population stratification

2000 • 377 citations

Polymorphisms of Methylenetetrahydrofolate Reductase and Other Enzymes: Metabolic Significance, Risks and Impact on Folate Requirement

1999 • 373 citations

The principles of human biochemical genetics

1972 • 347 citations

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects

1995 • 314 citations

The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

2000 • 274 citations

Single and Combined Prothrombotic Factors in Patients With Idiopathic Venous Thromboembolism

1999 • 258 citations

Tests and estimates of allelic association in complex inheritance

1998 • 250 citations

Homocysteine and Risk of Premature Coronary Heart Disease

1996 • 242 citations

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population

2001 • 241 citations

Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

2000 • 177 citations

Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.

1999 • 167 citations

Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

1998 • 160 citations

Lack of an association between apolipoprotein E ϵ4 and Alzheimer's disease in elderly nigerians

1995 • 159 citations

Pro12Ala Missense Mutation of the Peroxisome Proliferator Activated Receptor γ and Diabetes Mellitus

1999 • 157 citations

The Methylenetetrahydrofolate Reductase TT677 Genotype Is Associated with Venous Thrombosis Independently of the Coexistence of the FV Leiden and the Prothrombin

1998 • 141 citations

The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes

2000 • 137 citations

The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant

2001 • 133 citations

Susceptibility to spina bifida; an association study of five candidate genes

1998 • 116 citations

Prevalence of the prothrombin 20210 G-to-A variant in blacks: Infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects

1998 • 62 citations

Molecular mechanisms of activated protein C resistance. Properties of factor V isolated from an individual with homozygosity for the Arg506 to Gln mutation in the factor V gene

1996 • 55 citations