HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Direct Cloning and Sequence Analysis of Enzymatically Amplified Genomic Sequences

1986 • 766 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

HLA and Disease 1982 ‐ A Survey

1983 • 551 citations

Histocompatibility Testing 1984

1985 • 535 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Molecular diversity of HLA-DR4 haplotypes.

1986 • 385 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.

1985 • 340 citations

Polymorphism of human Ia antigens: gene conversion between two DR β loci results in a new HLA-D/DR specificity

1986 • 292 citations

Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes.

1983 • 271 citations

HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals

1983 • 265 citations

Maturity-Onset Diabetes of Youth in Black Americans

1987 • 262 citations

Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genes

1984 • 261 citations

Immunology of Insulin-Dependent Diabetes Mellitus

1985 • 240 citations

Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

1987 • 222 citations

Allelic variation in the DR subregion of the human major histocompatibility complex.

1987 • 220 citations

Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.

1986 • 193 citations

Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.

1984 • 190 citations

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis

1986 • 184 citations

Sequence polymorphism of HLA DRβ1 alleles relating to T-cell-recognized determinants

1985 • 183 citations

Structural organization of the DR subregion of the human major histocompatibility complex.

1985 • 173 citations

Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

1983 • 162 citations

Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci.

1985 • 160 citations

Linkage map of three HLA-DR beta-chain genes: evidence for a recent duplication event.

1985 • 155 citations

Gene organization of DC and DX subregions of the human major histocompatibility complex.

1985 • 146 citations

New HLA DNA polymorphisms associated with autoimmune diseases

1986 • 135 citations

A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.

1985 • 134 citations

Identification of a polymorphic variant associated with HLA-DQw3 and characterized by specific restriction sites within the DQ beta-chain gene.

1985 • 133 citations

Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta.

1984 • 129 citations

Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin-dependent diabetes mellitus with HLA-DQ.

1987 • 115 citations

Polymorphism of human Ia antigens generated by reciprocal intergenic exchange between two DR β loci

1986 • 111 citations

Measuring the genetic contribution of a single locus to a multilocus disease

1984 • 108 citations

HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus.

1984 • 107 citations

Sequence analysis and structure-function correlations of murine q, k, u, s, and f haplotype I-A beta cDNA clones.

1986 • 105 citations

Only one DQ-beta restriction fragment pattern of each DR specificity is associated with insulin-dependent diabetes.

1986 • 100 citations

Analysis of the Expression and Function of Class-II Major Histocompatibility Complex-Encoded Molecules by DNA-Mediated Gene Transfer

1986 • 96 citations

Complete characterization and sequence of an HLA class II DR beta chain cDNA from the DR5 haplotype.

1986 • 95 citations

HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.

1986 • 87 citations

Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype.

1986 • 80 citations

HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.

1987 • 77 citations

Reduced heat resistance of mutant spores after cloning and mutagenesis of the Bacillus subtilis gene encoding penicillin-binding protein 5

1986 • 69 citations

Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications.

1985 • 62 citations

Structural and functional variability among DQ ? alleles of DR2 subtypes

1987 • 56 citations

EcoK selection vectors for shotgun cloning into M13 and deletion mutagenesls

1985 • 48 citations

HLA-DR2-associated Dw subtypes correlate with RFLP clusters: most DR2 IDDM patients belong to one of these clusters

1986 • 45 citations

A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA system

1984 • 42 citations

Genetics of Type I diabetes mellitus: a single, recessive predisposition gene mapping between HLA-B and GLO. With an appendix on the estimation of selection bias.

1981 • 39 citations

Relation of insulin‐dependent diabetes mellitus (IDD) and the HLA‐linked SB system

1984 • 36 citations

Genetic heterogeneity of insulin-dependent (type I) diabetes mellitus: evidence from a study of extended haplotypes.

1984 • 36 citations

Methylation of the HLA-DR alpha gene is positively correlated with expression

1987 • 36 citations

DR2+ haplotypes in insulin-dependent diabetes: Analysis of DNA restriction fragment length polymorphisms

1986 • 25 citations

HLA Class II Antigens

1986 • 24 citations

DR5-Associated DC molecules carry three different allospecificities

1985 • 18 citations

Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-D

1986 • 15 citations

Molecular characterization of three HLA class II molecules on DR4 and DRw9 haplotypes: Serologic and structural relationships at the polypeptides level

1986 • 12 citations

Comparison of DR β1 alleles from diabetic and normal individuals

1987 • 11 citations

A novel HLA class II alloantigen detected by an alloantiserum TK2

1987 • 8 citations