Class III Alleles of the Variable Number of Tandem Repeat Insulin Polymorphism Associated with Silencing of Thymic Insulin Predispose to Type 1 Diabetes

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

1990 • 296 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

1994 • 219 citations

Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals

1985 • 208 citations

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

1998 • 188 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

Structure–Function Correlations of the Insulin-linked Polymorphic Region

1996 • 146 citations

Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals

1992 • 138 citations

Imprinted and Genotype-specific Expression of Genes at theIDDM2Locus in Pancreas and Leucocytes

1996 • 115 citations

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1997 • 112 citations

Insulin Gene Region-Encoded Susceptibility to IDDM Maps Upstream of the Insulin Gene

1995 • 91 citations

The human insulin gene linked polymorphic region exhibits an altered DNA structure

1992 • 86 citations

Localization of a Type I Diabetes Susceptibility Locus to the Variable Tandem Repeat Region Flanking the Insulin Gene

1993 • 86 citations

Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody

2000 • 82 citations

Cystosine-rich strands of the insulin minisatellite adopt hairpins with intercalated Cytosine + ·Cytosine pairs 1 1Edited by I. Tinoco

1997 • 78 citations

Variation in the sequence and modification state of the human insulin gene flanking regions

1982 • 74 citations

Allele diversity and germline mutation at the insulin minisatellite

2000 • 52 citations

An Insulin-like Thymic Factor: A Preliminary Report

1965 • 32 citations

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene

1996 • 29 citations