Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.

1981 • 1,606 citations

Construction of multilocus genetic linkage maps in humans.

1987 • 1,461 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

1996 • 941 citations

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

1990 • 886 citations

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.

1987 • 771 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

Diabetes mellitus in the pima indians: Incidence, risk factors and pathogenesis

1990 • 590 citations

An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians

1998 • 484 citations

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

1984 • 481 citations

Extensions to pedigree analysis III. Variance components by the scoring method

1976 • 438 citations

Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map

1994 • 405 citations

Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

1990 • 398 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Asymptotic properties of affected-sib-pair linkage analysis.

1993 • 378 citations

Regulation of a Transcription Factor Network Required for Differentiation and Metabolism

1998 • 343 citations

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

1996 • 330 citations

WHO Expert Committee on Diabetes Mellitus: second report.

1980 • 305 citations

Accurate Inference of Relationships in Sib-Pair Linkage Studies

1997 • 287 citations

Human Hepatocyte Nuclear Factor 4 Isoforms Are Encoded by Distinct and Differentially Expressed Genes

1996 • 236 citations

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

1997 • 232 citations

Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations

1996 • 225 citations

Frequency and Carrier Risk Associated with Common BRCA1 and BRCA2 Mutations in Ashkenazi Jewish Breast Cancer Patients

1998 • 223 citations

Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy

1997 • 214 citations

Substrate Nucleotide-Determined Non-Templated Addition of Adenine by Taq DNA Polymerase: Implications for PCR-Based Genotyping and Cloning

1996 • 170 citations

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene

1997 • 168 citations

New susceptibility locus for NIDDM is localized to human chromosome 20q

1997 • 143 citations

Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice.

1995 • 142 citations

Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY

1997 • 106 citations

Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group.

1997 • 100 citations

Mapping Genes for NIDDM: Design of the Finland—United States Investigation of NIDDM Genetics (FUSION) Study

1998 • 97 citations

A simple method to detect linkage for rare recessive diseases: An application to juvenile diabetes

1979 • 96 citations

Glucose Tolerance and Insulin Release, A Mathematical Approach: II. Approximation of the Peripheral Insulin Resistance After Oral Glucose Loading

1976 • 77 citations

Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM

1997 • 69 citations

Genetic Linkage Analysis of Complex Genetic Traits by Using Affected Sibling Pairs

1998 • 59 citations

Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.

1998 • 35 citations

69 Candidate genes in non-insulin-dependent diabetes mellitus

1997 • 1 citations

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