Physiology of the Neurotrophins

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

1990 • 993 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

Functional Interactions of Neurotrophins and Neurotrophin Receptors

1995 • 825 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF

1993 • 753 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

A BDNF autocrine loop in adult sensory neurons prevents cell death

1995 • 743 citations

Effects of ocular injury and administration ofbrain-derived neurotrophic factor on survival and regrowth of axotomized retinalganglion cells.

1994 • 727 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

1960 • 692 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

1993 • 685 citations

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

1994 • 685 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

1992 • 668 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

1994 • 635 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Neurotrophins promote motor neuron survival and are present in embryonic limb bud

1993 • 619 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

1992 • 603 citations

Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets

1994 • 581 citations

Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF

1995 • 572 citations

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

1992 • 564 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Nerve growth factor and nociception

1993 • 530 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells

1986 • 519 citations

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

1992 • 515 citations

Neurotrophin signal transduction by the Trk receptor

1994 • 511 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

The role of neurotrophins in the developing nervous system

1994 • 472 citations

Complementary roles of BDNF and NT-3 in vestibular and auditory development

1995 • 465 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Body and Brain: A Trophic Theory of Neural Connections

1992 • 426 citations

Nerve growth factor (NGF) in the rat CNS: Absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra

1979 • 422 citations

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

1995 • 413 citations

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

1994 • 394 citations

Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor

1985 • 384 citations

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

1995 • 381 citations

The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development.

1994 • 371 citations

Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization

1990 • 365 citations

p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins

1993 • 359 citations

A crucial role for neurotrophin-3 in oligodendrocyte development

1994 • 353 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

BDNF Protein Measured by a Novel Enzyme Immunoassay in Normal Brain and after Seizure: Partial Disagreement with mRNA Levels

1995 • 328 citations

Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia

1993 • 323 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

Neurotrophin receptor mRNA expression defines distinct populations of neurons in rat dorsal root ganglia

1995 • 307 citations

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

1993 • 293 citations

Sympathetic neuroblasts undergo a developmental switch in trophic dependence

1993 • 279 citations

p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF

1994 • 278 citations

Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development

1995 • 270 citations

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

1987 • 265 citations

Nerve growth factor (NGF) prevents the shift in ocular dominance distribution of visual cortical neurons in monocularly deprived rats

1992 • 255 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats

1989 • 252 citations

The response of chick sensory neurons to brain-derived neurotrophic factor

1986 • 251 citations

Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse

1990 • 227 citations

Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.

1994 • 225 citations

Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor

1992 • 204 citations

BDNF and NT-3 induce intracellular Ca2+ elevation in hippocampal neurones

1993 • 197 citations

Neurotrophic factors promote the maturation of developing sensory neurons before they become dependent on these factors for survival

1992 • 195 citations

Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF

1992 • 191 citations

In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells.

1987 • 187 citations

Requirement for nerve growth factor in the development of myelinated nociceptors in vivo

1991 • 176 citations

Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells

1991 • 176 citations

Neurotrophin 3 potentiates neuronal activity and inhibits gamma-aminobutyratergic synaptic transmission in cortical neurons.

1994 • 164 citations

Excitation of cutaneous afferent nerve endings in vitro by a combination of inflammatory mediators and conditioning effect of substance P

1992 • 157 citations

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

1984 • 152 citations

BDNF in the development of the visual system of Xenopus

1994 • 148 citations

Limbic seizures induce a differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, in the rat hippocampus

1992 • 148 citations

Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos

1994 • 133 citations

Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts

1994 • 125 citations

Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat

1994 • 122 citations

Spontaneous and evoked activity of fetal primary afferents in vivo

1987 • 122 citations

Neurotrophic factors: An evolutionary perspective

1994 • 121 citations

Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neurons

1991 • 112 citations

Short-term modulation of glutamatergic synapses in adult rat hippocampus by NGF

1994 • 112 citations

The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.

1994 • 111 citations

Localization of neurotrophin-3-like immunoreactivity in the rat central nervous system

1994 • 110 citations

Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

1993 • 110 citations

Sensory ganglia require neurotrophin-3 early in development

1994 • 107 citations

Dependence of developing group Ia afferents on neurotrophin‐3

1995 • 97 citations

Expression and binding characteristics of the BDNF receptor chick trkB

1993 • 94 citations

Differential Regulation of p21ras Activation in Neurons by Nerve Growth Factor and Brain-derived Neurotrophic Factor

1995 • 90 citations

Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system.

1994 • 90 citations

Fine structure of rat septohippocampal neurons: II. A time course analysis following axotomy

1992 • 89 citations

Sciatic nerve regeneration across gaps within silicone chambers: Long-term effects of NGF and consideration of axonal branching

1990 • 86 citations

Effect of nerve growth factor on synaptic depression after axotomy

1976 • 85 citations

Stages in the development of cat muscle spindles

1984 • 83 citations

Brain-derived neurotrophic factor stimulates survival and neuronal differentiation in cultured avian neural crest

1988 • 78 citations

BDNF Supports Mammalian Chemoafferent Neurons in Vitro and Following Peripheral Target Removal in Vivo

1994 • 72 citations

BDNF and NT-3 rescue sensory but not motoneurones following axotomy in the neonate.

1994 • 72 citations

The Biosynthesis of Neurotrophin Heterodimers by Transfected Mammalian Cells

1995 • 67 citations

Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells

1994 • 63 citations

Nerve growth factor and the peptidergic sensory neurons

1984 • 63 citations

Neurotrophin‐3 affects proliferation and differentiation of distinct neural crest cells and is present in the early neural tube of avian embryos

1993 • 63 citations

In vivo effects of neurotrophin-3 during sensory neurogenesis

1996 • 62 citations

Expression of trkC receptor mRNA during development of the avian nervous system

1994 • 61 citations

Grafting of additional periphery reduces embryonic loss of neurons

1979 • 61 citations

Fate of septohippocampal neurons following fimbria-fornix transection: A time course analysis

1990 • 59 citations

Regulation of Afferent Connectivity in the Adult Spinal Cord by Nerve Growth Factor

1992 • 59 citations

Development of the longitudinal projection patterns of lumbar primary sensory afferents in the chicken embryo

1995 • 59 citations

Embryonic sensory development: Local expression of neurotrophin‐3 and target expression of nerve growth factor

1994 • 58 citations

Molecular cloning and cellular localization of trk C in the chicken embryo

1993 • 52 citations

Purification and characterisation of a brain‐derived neurotrophic factor/ neurotrophin‐3 (BDNF/NT‐3) heterodimer

1994 • 51 citations

Antibodies against mouse nerve growth factor interfere in vivo with the development of avian sensory and sympathetic neurones

1988 • 44 citations

Formation of heterodimers from three neurotrophins, nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor.

1994 • 44 citations

Comparison of mammalian, chicken andXenopusbrain-derived neurotrophic factor coding sequences

1991 • 39 citations

Heterodimers of the neurotrophic factors: Formation, isolation, and differential stability

1993 • 34 citations

Developmentally Regulated Expression of mRNA for Neurotrophin High-Affinity (trk) Receptors within Chick Trigeminal Sensory Neurons

1995 • 33 citations

Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons?

1994 • 27 citations

Recombinant human brain-derived neurotrophic factor (rHuBDNF). Disulfide structure and characterization of BDNF expressed in CHO cells.

1993 • 16 citations

Target specificity and size of avian sensory neurons supported in vitro by nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3

1994 • 15 citations

Quantitative and histochemical aspects of the differentiation of muscle spindles in the anterior latissimus dorsi of the developing chick

1982 • 12 citations

Brain-Derived Neurotrophic Factor and the Developing Chick Retina

1995 • 8 citations

Antibodies to nerve growth factor

1980 • 2 citations