Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Degeneration and Regeneration of the Nervous System.

1929 • 2,924 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats

1981 • 1,679 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Compilation of vertebrate-encoded transcription factors

1992 • 934 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons

1992 • 752 citations

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA.

1992 • 719 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

1992 • 668 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Peripheral Nerve Regeneration

1990 • 560 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF

1992 • 346 citations

Increased production of the TrkB protein tyrosine kinase receptor after brain insults

1993 • 344 citations

Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons

1989 • 331 citations

The trk B tyrosine protein kinase is a receptor for neurotrophin-4

1992 • 326 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

1993 • 259 citations

Widespread and Developmentally Regulated Expression of Neurotrophin‐4 mRNA in Rat Brain and Peripheral Tissues

1993 • 256 citations

Cloning and expression of a cDNA encoding a novel human neurotrophic factor

1990 • 199 citations

Regulation of Neurotrophin mRNA Expression in the Rat Brain by Glucocorticoids

1992 • 191 citations

Denervation increases a neurite-promoting activity in extracts of skeletal muscle

1983 • 189 citations

Regulation of expression of fibronectin and its receptor, α5β1, during development and regeneration of peripheral nerve

1992 • 184 citations

Fibroblasts that proliferate near denervated synaptic sites in skeletal muscle synthesize the adhesive molecules tenascin(J1), N-CAM, fibronectin, and a heparan sulfate proteoglycan.

1989 • 183 citations

Expression of mRNAs for neurotrophin receptors in the dorsal root ganglion and spinal cord during development and following peripheral or central axotomy

1993 • 155 citations

Developmentally Regulated Expression of HDNF/NT‐3 mRNA in Rat Spinal Cord Motoneurons and Expression of BDNF mRNA in Embryonic Dorsal Root Ganglion

1991 • 138 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Expression of cytotactin in the normal and regenerating neuromuscular system.

1989 • 117 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

The role of laminin, a component of Schwann cell basal lamina, in rat sciatic nerve regeneration within antiserum-treated nerve grafts

1992 • 81 citations

Compartmentalized transcription of acetylcholine receptor genes during motor endplate epigenesis.

1991 • 55 citations

Regulation of putative muscle-derived neurotrophic factors by muscle activity and innervation: in vivo and in vitro studies

1991 • 50 citations

Motoneurone survival activity in extracts of denervated muscle reduced by prior stimulation of the muscle

1986 • 25 citations