Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion

1994 • 912 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

1994 • 804 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

1992 • 712 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

1993 • 670 citations

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

1994 • 635 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

1994 • 620 citations

Neurotrophins promote motor neuron survival and are present in embryonic limb bud

1993 • 619 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

1993 • 469 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

A crucial role for neurotrophin-3 in oligodendrocyte development

1994 • 353 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

The nerve growth factor family

1990 • 326 citations

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

1993 • 293 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Sympathetic neuroblasts undergo a developmental switch in trophic dependence

1993 • 279 citations

Selective dependence of mammalian dorsal root ganglion neurons on nerve growth factor during embryonic development

1992 • 240 citations

NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival

1993 • 218 citations

Nerve growth factor: a tale of two receptors.

1993 • 215 citations

Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

1994 • 212 citations

Neurotrophin 3 is a mitogen for cultured neural crest cells.

1992 • 192 citations

Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture.

1993 • 190 citations

Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons

1993 • 79 citations

Neurotrophin 3 stimulates the differentiation of motoneurons from avian neural tube progenitor cells.

1994 • 54 citations