Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

1994 • 1,066 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

1994 • 1,046 citations

Neurotrophic factors: from molecule to man

1994 • 800 citations

Isolation of a stem cell for neurons and glia from the mammalian neural crest

1992 • 796 citations

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

1988 • 760 citations

The neurotrophic factor concept: a reexamination

1993 • 745 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

The nerve growth factor family of receptors

1992 • 649 citations

Severe sensory and sympathetic deficits in mice lacking neurotrophin-3

1994 • 635 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons

1992 • 521 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1994 • 397 citations

Alternative forms of rat TrkC with different functional capabilities

1993 • 374 citations

Cell Line Segregation During Peripheral Nervous System Ontogeny

1986 • 361 citations

p75-Deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins

1993 • 359 citations

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.

1991 • 359 citations

p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells

1994 • 353 citations

Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture.

1989 • 347 citations

Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons

1993 • 338 citations

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry

1988 • 321 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Proliferation and differentiation of embryonic chick sympathetic neurons: Effects of ciliary neurotrophic factor

1989 • 297 citations

The low affinity NGF receptor, p75, can collaborate with each of the Trks to potentiate functional responses to the neurotrophins

1994 • 294 citations

[53] Long-term culture of dissociated sympathetic neurons

1979 • 294 citations

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

1993 • 293 citations

Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.

1993 • 292 citations

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

1993 • 290 citations

Sympathetic neuroblasts undergo a developmental switch in trophic dependence

1993 • 279 citations

p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF

1994 • 278 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

TrkA cross-linking mimics neuronal responses to nerve growth factor.

1994 • 222 citations

NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival

1993 • 218 citations

The relationship of cell division to the acquisition of adrenergic characteristics by developing sympathetic ganglion cell precursors

1978 • 213 citations

A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF

1990 • 205 citations

trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities.

1993 • 178 citations

Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation

1987 • 167 citations

Developmental changes of nerve growth factor levels in sympathetic ganglia and their target organs

1988 • 145 citations

Intrinsic programmes of growth and survival in developing vertebrate neurons

1994 • 139 citations

Membrane Depolarization Induces p140 ^trk and NGF Responsiveness, but Not p75 ^LNGFR , in MAH Cells

1992 • 120 citations

Neuroblast mitosis in dissociated culture: regulation and relationship to differentiation.

1990 • 113 citations

Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neurons

1991 • 112 citations

Regulation of expression of mRNAs encoding the nerve growth factor receptors p75 and trkA in developing sensory neurons

1993 • 103 citations

Nerve Growth Factor Derived from Terminals Selectively Increases the Ratio of p75 to trkA NGF Receptors on Mature Sympathetic Neurons

1994 • 103 citations

Neurotrophic Factors: Switching neurotrophin dependence

1994 • 96 citations

Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons

1993 • 79 citations

Neuronal differentiation triggered by blocking cell proliferation.

1992 • 68 citations

The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development

1994 • 66 citations

Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors

1992 • 66 citations

Development of the rat superior cervical ganglion: ingrowth of preganglionic axons

1985 • 63 citations

Expression of trkC receptor mRNA during development of the avian nervous system

1994 • 61 citations

MASH-1: a marker and a mutation for mammalian neural crest development.

1994 • 54 citations

Expression of noradrenergic and cholinergic traits by sympathetic neurons cultured without serum

1985 • 54 citations

Evidence that enteric neurons may derive from the sympathoadrenal lineage

1991 • 47 citations

Depolarization and insulin like growth factor-l (IGF-l) differentially regulate the mitotic cycle in cultured rat sympathetic neuroblasts

1989 • 42 citations

Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons.

1994 • 35 citations

Cell Fate and Gene Expression in the Developing Neural Crest

1988 • 20 citations

A Schwann cell antigen recognized by monoclonal antibody 217c is the rat low-affinity nerve growth factor receptor

1991 • 20 citations