HIF-1α expression regulates the bactericidal capacity of phagocytes

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

2003 • 1,909 citations

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

1997 • 1,325 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

Innate antimicrobial peptide protects the skin from invasive bacterial infection

2001 • 1,206 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

HIF-1 and mechanisms of hypoxia sensing

2001 • 1,131 citations

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

1997 • 1,004 citations

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

2001 • 867 citations

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

2005 • 803 citations

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

1998 • 572 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 443 citations

The hypoxic response of tumors is dependent on their microenvironment

2003 • 396 citations

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

1997 • 368 citations

Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1

1999 • 355 citations

Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines.

1997 • 340 citations

Hypoxic Regulation of Inducible Nitric Oxide Synthase via Hypoxia Inducible Factor-1 in Cardiac Myocytes

2000 • 309 citations

Accumulation of HIF-1α under the influence of nitric oxide

2001 • 257 citations

Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

1999 • 235 citations

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β ₂ integrin gene expression

2004 • 235 citations

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

2004 • 214 citations

Sword and shield: Linked group B streptococcal β-hemolysin/cytolysin and carotenoid pigment function to subvert host phagocyte defense

2004 • 213 citations

Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts

2000 • 210 citations

Expression of hypoxia-inducible factor 1? by macrophages in the rheumatoid synovium: Implications for targeting of therapeutic genes to the inflamed joint

2001 • 209 citations

The macrophage – a novel system to deliver gene therapy to pathological hypoxia

2000 • 208 citations

Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors

2003 • 202 citations

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine

1997 • 197 citations

Tumor Necrosis Factor-α Causes Accumulation of a Ubiquitinated Form of Hypoxia Inducible Factor-1α through a Nuclear Factor-κB-Dependent Pathway

2003 • 168 citations

Expression of HIF‐1α by human macrophages: implications for the use of macrophages in hypoxia‐regulated cancer gene therapy

2001 • 168 citations

Inverse Relation between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases

2000 • 167 citations

Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrins

1997 • 155 citations

Inducible Nitric Oxide Synthase - Time for Reappraisal

2002 • 150 citations

Role of Nitric Oxide in Host Defense in Murine Salmonellosis as a Function of Its Antibacterial and Antiapoptotic Activities

2002 • 148 citations

Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages

1995 • 145 citations

Streptolysin S and necrotising infections produced by group G streptococcus

2002 • 145 citations

Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds

2001 • 145 citations

Exogenous and endogenous nitric oxide attenuates tumor necrosis factor synthesis in the murine macrophage cell line RAW 264.7.

1995 • 108 citations

[42] Cathepsin G

1981 • 101 citations

Cathelicidins and Innate Defense Against Invasive Bacterial Infection

2003 • 94 citations

Necrotising fasciitis in a patient receiving infliximab for rheumatoid arthritis

2002 • 84 citations

Induction of macrophage nitric oxide production by interferon‐γ and tumor necrosis factor‐α is enhanced by interleukin‐10

1993 • 83 citations

Oxygen and the inflammatory cell

2003 • 80 citations

NO and TNF-α released from activated macrophages stabilize HIF-1α in resting tubular LLC-PK₁ cells

2003 • 78 citations

Nitric Oxide Modulates Pro- and Anti-inflammatory Cytokines in Lipopolysaccharide-Activated Macrophages

2003 • 70 citations

Nitric Oxide Modulates Interleukin-1 β and Tumor Necrosis Factor- α Synthesis by Alveolar Macrophages in Pulmonary Tuberculosis

2000 • 63 citations

Mice Lacking Inducible Nitric Oxide Synthase Demonstrate Impaired Killing of Porphyromonas gingivalis

2003 • 54 citations

Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization.

1987 • 48 citations

Nitric oxide inhibits LPS-induced tumor necrosis factor synthesis in vitro and in vivo

1996 • 42 citations

Hypoxia-inducible factor 1 alpha upregulates the expression of inducible nitric oxide synthase gene in pulmonary arteries of hyposic rat.

2002 • 31 citations

In vitro killing of oral Capnocytophaga by granule fractions of human neutrophils is associated with cathepsin G activity.

1991 • 29 citations

Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages

1999 • 28 citations

Mechanism of Staphylococcal Resistance to Non-oxidative Antimicrobial Action of Neutrophils: Importance of pH and Ionic Strength in Determining the Bactericidal Action of Cathepsin G

1989 • 28 citations

Effect of atmosphere of incubation on the isolation of group A streptococci from throat cultures.

1985 • 27 citations

Hypoxia of diabetic feet with abnormal arterial blood flow

1993 • 20 citations

Mastering innate immunity

2003 • 19 citations

In vitro Activity of the Human Neutrophil Cathepsin G on Eimeria tenella Sporozoites

1991 • 7 citations