A Schistosome-Expressed Immunomodulatory Glycoconjugate Expands Peritoneal Gr1+ Macrophages That Suppress Naive CD4+ T Cell Proliferation Via an IFN-γ and Nitric Oxide-Dependent Mechanism

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Other Functions, Other Genes

1999 • 686 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Interferon γ Eliminates Responding Cd4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated Cd4 T Cells

2000 • 340 citations

Alternative versus Classical Activation of Macrophages

1999 • 328 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Oligosaccharide-specific induction of interleukin 10 production by B220+ cells from schistosome-infected mice: a mechanism for regulation of CD4+ T-cell subsets.

1994 • 299 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.

1993 • 255 citations

Molecular Cloning of F4/80, a Murine Macrophage-restricted Cell Surface Glycoprotein with Homology to the G-protein-linked Transmembrane 7 Hormone Receptor Family

1996 • 230 citations

Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact

2000 • 219 citations

Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture.

1981 • 216 citations

Lacto-N-fucopentaose III Found on Schitosoma mansoni Egg Antigens Functions as Adjuvant for Proteins by Inducing Th2-Type Response

2001 • 212 citations

Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses

1998 • 160 citations

Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes

2000 • 155 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity

2000 • 146 citations

Our shifting understanding of the role of nitric oxide in autoimmune encephalomyelitis: a review

1999 • 141 citations

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

2000 • 139 citations

A Schistosoma mansoni epitope recognized by a protective monoclonal antibody is identical to the stage-specific embryonic antigen 1.

1990 • 122 citations

APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production

1996 • 108 citations

B-1 cell (CD5+B220+) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars.

1997 • 105 citations

Requirement for In Vivo Production of IL-4, But Not IL-10, in the Induction of Proliferative Suppression by Filarial Parasites

1998 • 98 citations

Antigen‐presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4 ⁺ T cells

2000 • 96 citations

Effect of anti-interleukin 12 treatment on murine lyme borreliosis.

1996 • 96 citations

Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ

2000 • 93 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 83 citations

Involvement of nitric oxide in bone marrow-derived natural suppressor activity. Its dependence on IFN-gamma.

1995 • 80 citations

Antigen-presenting cells recruited byBrugia malayi induce Th2 differentiation of naïve CD4+ T cells

2000 • 78 citations

Expression of Lex antigen in Schistosoma japonicum and S.haematobium and immune responses to Lex in infected animals: Lack of Lex expression in other trematodes and nematodes

1998 • 76 citations

Lewisx-containing oligosaccharide attenuates schistosome egg antigen-induced immune depression in human schistosomiasis

2000 • 71 citations

Ki‐67 (MIB1), p53, and Lewis‐X (LeuM1) as Prognostic Factors of Recurrence in T1 and T2 Laryngeal Carcinoma

2000 • 59 citations

Macrophages from schistosomal egg granulomas induce unresponsiveness in specific cloned Th-1 lymphocytes in vitro and down-regulate schistosomal granulomatous disease in vivo.

1994 • 57 citations

A Monoclonal Antibody Directed Against the Murine Macrophage Surface Molecule F4/80 Modulates Natural Immune Response toListeria monocytogenes

1999 • 40 citations

Schistosomal granuloma modulation. II. Specific immunogenic carbohydrates can modulate schistosome-egg-antigen-induced hepatic granuloma formation

1999 • 37 citations

Administration of Glucocorticoids Markedly Increases the Numbers of Granulocytes and Extrathymic T Cells in the Bone Marrow

1999 • 34 citations

THE INHIBITORY EFFECT OF CYCLOPHOSPHAMIDE-INDUCED MAC-1+ NATURAL SUPPRESSOR CELLS ON IL-2 AND IL-4 UTILIZATION IN MLR

1994 • 32 citations

Interleukin-12 and tumor necrosis factor alpha mediate innate production of gamma interferon by group B Streptococcus-treated splenocytes of severe combined immunodeficiency mice

1996 • 29 citations

Transforming growth factor-β is the major mediator of natural suppressor cells derived from normal bone marrow

1992 • 28 citations

Tumour Growth Causes Suppression of Autoreactive T‐Cell Proliferation by Disrupting Macrophage Responsiveness to Interferon‐γ

1994 • 24 citations

Increasing infiltration and activation of CD8+ tumor-infiltrating lymphocytes after eliminating immune suppressive granulocyte/macrophage progenitor cells with low doses of interferon ? plus tumor necrosis factor ?

1994 • 17 citations

Schistosomal granuloma modulation

1999 • 14 citations

Suppressive Antigen-Presenting Cells in Helminth Infection

1999 • 12 citations

Deleted Work

1955 • 0 citations