The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene.

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation. Its role in resistance to Listeria monocytogenes.

1993 • 255 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Activation of mouse macrophages for tumor cell killing. I. Quantitative analysis of interactions between lymphokine and lipopolysaccharide.

1981 • 172 citations

Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.

1990 • 130 citations

Macrophage nitric oxide synthesis delays progression of ultraviolet light-induced murine skin cancers.

1993 • 109 citations

Mechanisms of macrophage‐mediated tumor cell killing: A comparative analysis of the roles of reactive nitrogen intermediates and tumor necrosis factor

1990 • 106 citations

Phenotype and functions of intratumoral macrophages

1986 • 105 citations

Release of nitric oxide during the T cell-independent pathway of macrophage activation

1993 • 101 citations

Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. II. Down-regulation of macrophage-mediated cytotoxicity by tumor-derived granulocyte-macrophage colony-stimulating factor.

1991 • 88 citations

Isolation of Tumoricidal Macrophages From Lung Melanoma Metastases of Mice Treated Systemically With Liposomes Containing a Lipophilic Derivative of Muramyl Dipeptide<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1982 • 80 citations

Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine.

1994 • 79 citations

Formation of isotonic Nycodenz gradients for cell separations

1982 • 43 citations

Promoter analysis of an interferon-inducible gene associated with macrophage activation.

1994 • 36 citations

Tumor cells suppress cytokine‐induced nitric‐oxide (no) production in cerebral endothelial cells

1994 • 34 citations

The activation state of macrophage subpopulations from a murine fibrosarcoma

1980 • 33 citations

Subversion of host defense mechanisms by malignant tumors: an established tumor as a privileged site for bacterial growth.

1977 • 32 citations

Response of Hyperplastic Alveolar Nodule Outgrowth-Line D1 to Mammary Tumor Virus, Nodule-Inducing Virus, and Prolonged Hormonal Stimulation Acting Singly and in Combination<xref ref-type="fn" rid="FN2">2</xref>

1969 • 31 citations

Decreased macrophage‐mediated cytotoxicity in mammary‐tumor‐bearing mice is related to alteration of nitric‐oxide production and/or release

1995 • 30 citations

Tumoricidal Activity of Alveolar and Peritoneal Macrophages of C57BL/6 Mice Bearing Metastatic or Nonmetastatic Variants of Lewis Lung Carcinoma

1991 • 25 citations

Differential utilization of IFN-gamma-responsive elements in two maturationally distinct macrophage cell lines.

1995 • 23 citations

IN-SITU ACTIVATED MACROPHAGES ARE INVOLVED IN HOST-RESISTANCE TO LYMPHOMA METASTASIS BY PRODUCTION OF NITRIC-OXIDE

1995 • 17 citations

IMPAIRED ACTIVATION OF TUMORICIDAL FUNCTION IN MACROPHAGES FROM MAMMARY-TUMOR BEARERS - THE ROLE OF IFN-GAMMA

1993 • 13 citations

Defective Production of Reactive Oxygen Intermediates by Tumor-Associated Macrophages Exposed to Phorbol Ester

1987 • 11 citations