HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

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Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1999 • 1,987 citations

Innate Immunity

2000 • 1,715 citations

HIF-1alpha is required for solid tumor formation and embryonic vascularization

1998 • 1,567 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

HIF-1 and mechanisms of hypoxia sensing

2001 • 1,131 citations

Phagocytes and oxidative stress

2000 • 1,055 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

Arthritis Provoked by Linked T and B Cell Recognition of a Glycolytic Enzyme

1999 • 620 citations

Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

2001 • 602 citations

Energy Metabolism of Human Neutrophils during Phagocytosis

1982 • 458 citations

Macrophage responses to hypoxia: relevance to disease mechanisms

1999 • 391 citations

Biological consequences of tumor hypoxia

2001 • 343 citations

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α

2001 • 303 citations

Invasion of brain microvascular endothelial cells by group B streptococci

1997 • 298 citations

Bioenergetics of immune functions: fundamental and therapeutic aspects

2000 • 286 citations

Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease

2001 • 263 citations

Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

1999 • 235 citations

Hypoxia, oxidative stress and rheumatoid arthritis

1995 • 229 citations

Expression of hypoxia-inducible factor 1? by macrophages in the rheumatoid synovium: Implications for targeting of therapeutic genes to the inflamed joint

2001 • 209 citations

Measurement of pH and ionic composition of pericellular sites

1975 • 202 citations

Differences in Oxygen Metabolism of Phagocytosing Monocytes and Neutrophils

1978 • 201 citations

The von Hippel-Lindau Tumor Suppressor Gene

2020 • 201 citations

Ultrastructural, histological, and biochemical alterations produced by 12-O-tetradecanoyl-phorbol-13-acetate on mouse epidermis and their relevance to skin tumor promotion.

1973 • 196 citations

Expression of HIF‐1α by human macrophages: implications for the use of macrophages in hypoxia‐regulated cancer gene therapy

2001 • 168 citations

VPF/VEGF and the angiogenic response

2000 • 150 citations

Signaling Takes a Breath – New Quantitative Perspectives on Bioenergetics and Signal Transduction

2001 • 141 citations

Targeted disruption of CD43 gene enhances T lymphocyte adhesion.

1993 • 134 citations

Hypoxia-Inducible Factor 1

1998 • 131 citations

2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation.

1976 • 123 citations

Chemotactic factor‐induced generation of superoxide radicals by human neutrophils

1979 • 122 citations

Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood

1999 • 121 citations

Hyperbaric oxygen therapy in acute necrotizing infections. With a special reference to the effects on tissue gas tensions.

2000 • 120 citations

Regional manifestations and control of the immune system

2002 • 120 citations

Hypoxia inhibits macrophage migration

1999 • 117 citations

Effect of hypoxia on release of IL-1 and TNF by human alveolar macrophages.

1996 • 103 citations

Analysis of pH, pO2 and pCO2 in drainage fluid allows for rapid detection of infectious complications during the follow-up period after abdominal surgery

1994 • 98 citations

Resolution of cutaneous inflammation after local elimination of macrophages

2000 • 92 citations

Tumor hypoxia, the physiological link between Trousseau's syndrome (carcinoma-induced coagulopathy) and metastasis.

2001 • 86 citations

The Peritoneal Environment During Infection

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Glycogenolysis versus glucose transport in human granulocytes: differential activation in phagocytosis and chemotaxis

1982 • 76 citations

THE ACTION OF LEUCOCYTES ON GLUCOSE

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Granulocytes utilize different energy sources for movement and phagocytosis

1982 • 66 citations

THE NATURE OF LEUKEMIC BLOOD CELLS AS DETERMINED BY THEIR METABOLISM

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Regulation of Energy Metabolism in Macrophages during Hypoxia

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Glycogenolysis versus glucose transport in human granulocytes: differential activation in phagocytosis and chemotaxis

1982 • 60 citations

Influence of Inhibitors of Cellular Function on Chemotactic Factor-Induced Neutrophil Aggregation

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Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages.

1995 • 49 citations

Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization.

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Modulation of Leukocyte Behavior by an Inflamed Extracellular Matrix

2000 • 47 citations

ON THE ACTION OF LEUCOCYTES ON GLUCOSE

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The effect of 2‐deoxyglucose on guinea pig polymorphonuclear leukocyte phagocytosis

1977 • 42 citations

Inhibition of 12-O-Tetradecanoylphorbol-13-Acetate-lnduced Increase in Vascular Permeability in Mouse Skin by Lipoxygenase Inhibitors

1985 • 38 citations

Comparison of synovial PO2 and sympathetic vasoconstrictor responses in normal and acutely inflamed rabbit knee joints

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Einige Übereinstimmungen im Stoffwechsel der Carcinomzellen und Exsudatleukocyten

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2-Deoxyglucose and inflammation

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Inflammation, glycolytic metabolism, and glycosaminoglycans

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Inflammation and Transcutaneous Measurement of Oxygen Pressure in Dermatology

1987 • 8 citations

Effects of 2-deoxy-D-glucose on human monocyte metabolism and function.

1980 • 8 citations

A Metabolic Comparison between Human Blood Monocytes and Neutrophils

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[The energy situation in the course of acute experimental inflammation].

1967 • 3 citations

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1967 • 1 citations