Hepatitis B virus X protein: a multifunctional viral regulator

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.

2001 • 544 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Woodchuck hepatitis virus X protein is required for viral infection in vivo

1994 • 443 citations

A transcription reinitiation intermediate that is stabilized by activator

2000 • 407 citations

Mediator of Transcriptional Regulation

2000 • 404 citations

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

2000 • 393 citations

Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

2000 • 367 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Hepatitis B Virus X Protein Colocalizes to Mitochondria with a Human Voltage-Dependent Anion Channel, HVDAC3, and Alters Its Transmembrane Potential

2000 • 306 citations

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

1997 • 302 citations

Hepatitis B Virus X Protein Interferes with Cellular DNA Repair

1998 • 272 citations

Hepatitis B virus X protein interacts with a probable cellular DNA repair protein

1995 • 249 citations

Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein

1999 • 243 citations

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

1996 • 237 citations

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

1997 • 228 citations

Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

1999 • 227 citations

Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication

1998 • 220 citations

Control of elongation by RNA polymerase II

2000 • 206 citations

Hepatitis B Virus X Protein Inhibits Transforming Growth Factor-β-induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway

2000 • 189 citations

Association of hepatitis B virus X protein with mitochondria causes mitochondrial aggregation at the nuclear periphery, leading to cell death

1999 • 183 citations

Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virusX gene

1996 • 182 citations

The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

1998 • 174 citations

p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro

1998 • 173 citations

Proteasome complex as a potential cellular target of hepatitis B virus X protein

1996 • 170 citations

Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism

2001 • 169 citations

Differential gene expression between chronic hepatitis B and C hepatic lesion

2001 • 168 citations

X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and Is Associated with Up-regulation of the SAPK/JNK Pathway

2001 • 168 citations

Hepatitis B virus X protein inhibits nucleotide excision repair

1999 • 166 citations

Intracellular localization of the hepatitis B virus HBx protein

2001 • 164 citations

Hepatitis B Virus X Protein: Structure, Function and Biology

1999 • 163 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Hepatitis B Virus pX Targets TFIIB in Transcription Coactivation

1998 • 145 citations

Structural and Functional Characterization of Interaction between Hepatitis B Virus X Protein and the Proteasome Complex

2000 • 141 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.

1996 • 137 citations

The Hepatitis B Virus HBx Protein Inhibits Caspase 3 Activity

1998 • 130 citations

Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα

1999 • 130 citations

Transcriptional repression of the human p53 gene by hepatitis B viral X protein

2000 • 119 citations

Hepatitis B Virus X Protein Acts as a Tumor Promoter in Development of Diethylnitrosamine-Induced Preneoplastic Lesions

2001 • 117 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: evolutional relationship between hepadnaviruses

1985 • 117 citations

Role of NF-κB and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein

2001 • 116 citations

Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants

1997 • 109 citations

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

1998 • 107 citations

Activation of RNA polymerase II transcription

1999 • 106 citations

RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein

1998 • 104 citations

Human Hepatitis B Virus X Protein Is a Possible Mediator of Hypoxia-Induced Angiogenesis in Hepatocarcinogenesis

2000 • 103 citations

Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-κB

2001 • 102 citations

pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner.

1996 • 102 citations

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas

1999 • 100 citations

p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53

1998 • 99 citations

The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway

1998 • 96 citations

Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G ₁ Transit via a Src Kinase Pathway

2001 • 90 citations

Interaction of the Hepatitis B Virus X Protein with the Crm1-dependent Nuclear Export Pathway

2001 • 89 citations

The Hepatitis B Virus X Protein Enhances the DNA Binding Potential and Transcription Efficacy of bZip Transcription Factors

1997 • 84 citations

Interaction of Hepatitis B Viral X Protein and CCAAT/ Enhancer-binding Protein α Synergistically Activates the Hepatitis B Viral Enhancer II/Pregenomic Promoter

1999 • 83 citations

Induction of apoptosis after switch-on of the hepatitis B virus X gene mediated by the Cre/loxP recombination system

1999 • 82 citations

Characterization of the hepatitis B virus EnhI enhancer and X promoter complex

1991 • 80 citations

The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines

1999 • 80 citations

Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts

2000 • 79 citations

Human interleukin 6 gene is activated by hepatitis B virus-X protein in human hepatoma cells.

1998 • 76 citations

Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

2001 • 74 citations

Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses

2000 • 70 citations

Differential Immediate Early Gene Expression in Conditional Hepatitis B Virus pX-transforming VersusNontransforming Hepatocyte Cell Lines

1999 • 69 citations

Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis

2000 • 65 citations

Expression of Fas ligand in human hepatoma cell lines: Role of hepatitis-B virus X (HBX) in induction of Fas ligand

1999 • 62 citations

Hepatitis B Viral Transactivator HBx Alleviates p53-mediated Repression of α-Fetoprotein Gene Expression

2000 • 61 citations

Selective Transcriptional Regulations in the Human Liver Cell by Hepatitis B Viral X Protein

2000 • 61 citations

RNA polymerase subunit RPB5 plays a role in transcriptional activation

1998 • 55 citations

Transactivation of Human Hepatitis B Virus X Protein, HBx, Operates through a Mechanism Distinct from Protein Kinase C and Okadaic Acid Activation Pathways

1994 • 55 citations

Identification of Multiple Transcription Factors, HLF, FTF, and E4BP4, Controlling Hepatitis B Virus Enhancer II

2000 • 54 citations

Expression of Hepatitis B Virus X Protein Does Not Alter the Accumulation of Spontaneous Mutations in Transgenic Mice

2000 • 54 citations

Direct Interaction between the Subunit RAP30 of Transcription Factor IIF (TFIIF) and RNA Polymerase Subunit 5, Which Contributes to the Association between TFIIF and RNA Polymerase II

2001 • 53 citations

UVDDB p127-binding modulates activities and intracellular distribution of Hepatitis B virus X protein

2000 • 52 citations

Metabolic Labeling of Woodchuck Hepatitis B Virus X Protein in Naturally Infected Hepatocytes Reveals a Bimodal Half-Life and Association with the Nuclear Framework

1998 • 44 citations

Hepatitis B Virus X Protein Transactivates the Inducible Nitric Oxide Synthase Promoter

1999 • 38 citations

Different Regions of Hepatitis B Virus X Protein Are Required for Enhancement of bZip-Mediated Transactivation versus Transrepression

2000 • 38 citations

Transcriptional Repression of Human Hepatitis B Virus Genes by a bZIP Family Member, E4BP4

1999 • 34 citations

The Hepatitis B Virus X Protein Transactivates Viral Core Gene Expression In Vivo

1999 • 31 citations

The Hepatitis B pX Protein Promotes Dimerization and DNA Binding of Cellular Basic Region/Leucine Zipper Proteins by Targeting the Conserved Basic Region

1999 • 29 citations

Insight Into the Tumor Suppressor Function of CBP Through the Viral Oncoprotein Tax

2001 • 28 citations

HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX

1999 • 27 citations

Human hepatitis B virus enhancer 1 is responsive to human interleukin-6

1997 • 27 citations

Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation

2000 • 27 citations

Human hepatitis B virus X protein augments the DNA binding of nuclear factor for IL-6 through its basic-leucine zipper domain

1999 • 26 citations

Human hepatitis B virus X protein is detectable in nuclei of transfected cells, and is active for transactivation

1999 • 23 citations

Insulin Activates the Hepatitis B VirusXGene through the Activating Protein-1 Binding Site in HepG2 Cells

1998 • 22 citations

Characterization of the Role of individual Protein Binding Motifs within the Hepatitis B Virus Enhancer I on X Promoter Activity Using Linker Scanning Mutagenesis

1993 • 19 citations

Hepatitis B Virus X Protein Activates Transcription by Bypassing CREB Phosphorylation, Not by Stabilizing bZIP−DNA Complexes

2000 • 9 citations

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