Erk Associates with and Primes GSK-3β for Its Inactivation Resulting in Upregulation of β-Catenin

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

2002 • 1,942 citations

The renaissance of GSK3

2001 • 1,459 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

HBx gene of hepatitis B virus induces liver cancer in transgenic mice

1991 • 1,155 citations

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

2001 • 1,107 citations

Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas

1998 • 1,085 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a

2004 • 845 citations

β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

2000 • 760 citations

Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction

1999 • 722 citations

Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway

2002 • 698 citations

Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation

1994 • 578 citations

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

1999 • 525 citations

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

2002 • 463 citations

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions

1991 • 457 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling

2000 • 418 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

Glycogen synthase kinase 3: an emerging therapeutic target

2002 • 399 citations

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1996 • 396 citations

β-catenin interacts with and inhibits NF-κB in human colon and breast cancer

2002 • 354 citations

β-catenin mutation and overexpression in hepatocellular carcinoma

2001 • 347 citations

Hepatitis B virus X protein: a multifunctional viral regulator

2001 • 323 citations

Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression

1999 • 313 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

A novel viral mechanism for dysregulation of β-catenin in Kaposi's sarcoma–associated herpesvirus latency

2003 • 307 citations

Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

2001 • 306 citations

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

1997 • 286 citations

Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases

1996 • 283 citations

Docking Motif Interactions in MAP Kinases Revealed by Hydrogen Exchange Mass Spectrometry

2004 • 279 citations

Exogenous Expression of β-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest

1999 • 278 citations

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of β-catenin

2000 • 265 citations

Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins

1996 • 237 citations

HBx Protein of Hepatitis B Virus Activates Jak1-STAT Signaling

1998 • 230 citations

Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

2003 • 220 citations

Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.

1995 • 190 citations

Hepatitis B Virus X Protein Inhibits Transforming Growth Factor-β-induced Apoptosis through the Activation of Phosphatidylinositol 3-Kinase Pathway

2000 • 189 citations

WNT-1 and HGF Regulate GSK3β Activity and β-Catenin Signaling in Mammary Epithelial Cells

1998 • 187 citations

Epstein-Barr Virus Latent Membrane Protein 2A Activates β-Catenin Signaling in Epithelial Cells

2003 • 179 citations

Growth factors regulate β-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing

2003 • 141 citations

Wnt-signalling pathway in ovarian epithelial tumours: increased expression of β-catenin and GSK3β

2003 • 133 citations

Fibroblast Growth Factor-2 Induces Lef/Tcf-dependent Transcription in Human Endothelial Cells

2002 • 127 citations

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

2004 • 126 citations

Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry

2003 • 115 citations

Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation

1999 • 105 citations

Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction

2000 • 97 citations

β ‐Catenin expression in hepatocellular carcinoma: A possible participation of β ‐catenin in the dedifferentiation process

2002 • 88 citations

Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos

1999 • 88 citations

Interaction between JCV large T-antigen and β-catenin

2004 • 67 citations

Hepatitis B virus-induced hepatocellular carcinoma: possible roles for HBx

1996 • 49 citations

Deleted Work

1955 • 0 citations