Modulation of the Transforming Growth Factor-β Signal Transduction Pathway by Hepatitis C Virus Nonstructural 5A Protein

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease

1991 • 854 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Hepatitis C Virus Infection in Post-Transfusion Hepatitis

1991 • 538 citations

Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

2000 • 505 citations

Effect of Alpha Interferon on the Hepatitis C Virus Replicon

2001 • 450 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Transforming growth factors and the regulation of cell proliferation

1990 • 390 citations

Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells

1997 • 357 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Hepatitis C Virus NS5A Colocalizes with the Core Protein on Lipid Droplets and Interacts with Apolipoproteins

2002 • 300 citations

TGF-β receptors and actions

1994 • 291 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase

1999 • 259 citations

Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner

2001 • 248 citations

Hepatitis C Virus RNA Polymerase and NS5A Complex with a SNARE-like Protein

1999 • 246 citations

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

2002 • 235 citations

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

1999 • 229 citations

Hepatitis C and liver fibrosis

2003 • 204 citations

Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest.

1991 • 203 citations

Molecular mechanisms of inactivation of TGF-β receptors during carcinogenesis

2000 • 186 citations

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

2002 • 176 citations

Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth.

1999 • 172 citations

Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGFβ

1986 • 166 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

Mechanism of Transcriptional Repression of E2F by the Retinoblastoma Tumor Suppressor Protein

1999 • 128 citations

Hepatitis C Virus NS5A Protein Impairs TNF-Mediated Hepatic Apoptosis, but Not by an Anti-FAS Antibody, in Transgenic Mice

2002 • 113 citations

E1A Inhibits Transforming Growth Factor-β Signaling through Binding to Smad Proteins

1999 • 108 citations

Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A

1996 • 99 citations

The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence

2002 • 93 citations

Hepatitis C virus NS5A protein protects against TNF-α mediated apoptotic cell death

2000 • 93 citations

Development of Hepatocellular Carcinoma Among Patients with Chronic Liver Disease due to Hepatitis C Viral Infection

1994 • 87 citations

Hepatitis C Virus NS5A Protein Modulates c-Jun N-terminal Kinase through Interaction with Tumor Necrosis Factor Receptor-associated Factor 2

2003 • 76 citations

Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3

2002 • 72 citations

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-α catalytic subunit

1997 • 69 citations

Nonstructural 5A Protein of Hepatitis C Virus Modulates Tumor Necrosis Factor α-stimulated Nuclear Factor κB Activation

2002 • 61 citations

Roles of Phosphatidylinositol 3-Kinase and Rac in the Nuclear Signaling by Tumor Necrosis Factor-α in Rat-2 Fibroblasts

1999 • 59 citations

Regulatory mechanisms for transforming growth factorβ as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of Smads in its growth

2000 • 48 citations

TGF-β: receptors and cell cycle arrest

1996 • 46 citations

Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-β pathway

2002 • 45 citations

Transforming growth factor beta and the cell surface in tumor progression

1993 • 41 citations

Antifibrogenic Therapies in Chronic HCV Infection

2001 • 39 citations

Transforming growth factor beta in hepatitis C virus infection: In vivo and in vitro findings

2003 • 33 citations

Full Genome Cloning and Nucleotide Sequence Analysis of Hepatitis C Virus from Sera of Chronic Hepatitis Patients in Korea

1993 • 18 citations

Relation of type II transforming growth factor-beta receptor to hepatic fibrosis and hepatocellular carcinoma.

2001 • 14 citations