Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

WebLogo: A Sequence Logo Generator: Figure 1

2004 • 11,504 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Global epidemiology of hepatitis C virus infection

2005 • 2,772 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

STATs in oncogenesis

2000 • 1,723 citations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

2003 • 1,594 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

2005 • 1,062 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

2005 • 799 citations

Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

2005 • 547 citations

γ-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair

2005 • 518 citations

Hepatitis C virus infection in patients with non‐Hodgkin's lymphoma

1994 • 459 citations

Effect of Alpha Interferon on the Hepatitis C Virus Replicon

2001 • 450 citations

ScanProsite: a reference implementation of a PROSITE scanning tool.

2002 • 425 citations

The Los Alamos hepatitis C sequence database

2004 • 380 citations

ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

2002 • 356 citations

ATM: Genome stability, neuronal development, and cancer cross paths

2001 • 304 citations

Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines

2000 • 280 citations

Histone H2AX Phosphorylation as a Predictor of Radiosensitivity and Target for Radiotherapy

2004 • 276 citations

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

2004 • 261 citations

Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection

2003 • 251 citations

Hepatitis C Virus RNA Polymerase and NS5A Complex with a SNARE-like Protein

1999 • 246 citations

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

2006 • 238 citations

DNA damage tumor suppressor genes and genomic instability

2003 • 230 citations

Hepatitis C Virus Infection Activates the Immunologic (Type II) Isoform of Nitric Oxide Synthase and Thereby Enhances DNA Damage and Mutations of Cellular Genes

2004 • 189 citations

Localization of a Portion of Extranuclear ATM to Peroxisomes

1999 • 189 citations

ATM binds to β-adaptin in cytoplasmic vesicles

1998 • 186 citations

Characterization of ATM Expression, Localization, and Associated DNA-dependent Protein Kinase Activity

1998 • 185 citations

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

2000 • 169 citations

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

1997 • 164 citations

The Product of the ATM Gene Is a 370-kDa Nuclear Phosphoprotein

1996 • 131 citations

STAT Signaling in the Pathogenesis and Treatment of Cancer

1999 • 115 citations

Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development

1998 • 106 citations

Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks

2004 • 103 citations

NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner

2006 • 91 citations

Mining viral protease data to extract cleavage knowledge

2002 • 86 citations

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization

1997 • 74 citations

Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association

2005 • 49 citations

The C-Terminal Transmembrane Domain of Hepatitis C Virus (HCV) RNA Polymerase Is Essential for HCV Replication In Vivo

2004 • 37 citations