Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Summaries of Affymetrix GeneChip probe level data

2003 • 4,927 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Functional Discovery via a Compendium of Expression Profiles

2000 • 2,581 citations

Excitotoxic cell death

1992 • 2,307 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

1999 • 2,023 citations

Apoptosis in the nervous system

2000 • 1,850 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

A network-based analysis of systemic inflammation in humans

2005 • 1,388 citations

Cognitive Neuroscience and the Study of Memory

1998 • 1,294 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

2000 • 1,201 citations

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

1993 • 1,165 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

2005 • 977 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis

2004 • 944 citations

Molecular pathways to neurodegeneration

2004 • 732 citations

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1997 • 724 citations

Postsynaptic Signaling and Plasticity Mechanisms

2002 • 713 citations

Defining the CREB Regulon

2004 • 708 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis

1998 • 668 citations

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

2004 • 650 citations

The Yin and Yang of NMDA receptor signalling

2003 • 627 citations

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

2001 • 530 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

Integrative analysis of the cancer transcriptome

2005 • 494 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

2003 • 421 citations

Identification of BTG2, an antiproliferative p53–dependent component of the DNA damage cellular response pathway

1996 • 416 citations

From signatures to models: understanding cancer using microarrays

2005 • 383 citations

p53 in neuronal apoptosis

2005 • 374 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

2005 • 329 citations

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

2003 • 296 citations

Combinatorial control of protein phosphatase-1

2001 • 293 citations

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

1991 • 288 citations

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells

2004 • 284 citations

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

1999 • 278 citations

Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation

2003 • 261 citations

Nuclear Ca²+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

2005 • 258 citations

The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis

1999 • 238 citations

Regulation of CBP-Mediated Transcription by Neuronal Calcium Signaling

1999 • 220 citations

The gene PC3^TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?

2001 • 207 citations

Expression of the antiproliferative gene TIS21 at the onset of neurogenesis identifies single neuroepithelial cells that switch from proliferative to neuron-generating division

1999 • 203 citations

AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats

2004 • 190 citations

Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons

2000 • 190 citations

Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes

2001 • 175 citations

Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters

1991 • 166 citations

Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133

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N-methyl-d-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons

1995 • 158 citations

Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis‐dependent plasticity

2004 • 154 citations

Hsp70 Gene Transfer by Adeno-associated Virus Inhibits MPTP-Induced Nigrostriatal Degeneration in the Mouse Model of Parkinson Disease

2004 • 143 citations

The Leukemia-associated Protein Btg1 and the p53-regulated Protein Btg2 Interact with the Homeoprotein Hoxb9 and Enhance Its Transcriptional Activation

2000 • 135 citations

Molecular Pathogenesis of Non-Hodgkin's Lymphoma: the Role of Bcl-6

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hCLCA1 and mCLCA3 Are Secreted Non-integral Membrane Proteins and Therefore Are Not Ion Channels

2005 • 127 citations

Transcription‐dependent neuronal plasticity

2000 • 110 citations

Tumor Suppression by a Proapoptotic Calcium-activated Chloride Channel in Mammary Epithelium

2001 • 94 citations

Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells

2005 • 82 citations

Functional Elimination of Calmodulin within the Nucleus by Targeted Expression of an Inhibitor Peptide

1995 • 80 citations

Molecular mechanisms of gene expression regulation by the apoptosis-promoting protein TIA-1.

2001 • 78 citations

BTG2TIS21/PC3 induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells

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B-Cell Translocation Gene 2 (Btg2) Regulates Vertebral Patterning by Modulating Bone Morphogenetic Protein/Smad Signaling

2004 • 68 citations

Mediators of ischemic preconditioning identified by microarray analysis of rat spinal cord

2003 • 68 citations

Identification and analysis of plasticity-induced late-response genes

2004 • 63 citations

Transcriptional or translational inhibition blocks low dose NMDA-mediated cell death

1995 • 58 citations

Novel conserved hydrolase domain in the CLCA family of alleged calcium‐activated chloride channels

2006 • 53 citations

Developmental expression of PC3 gene is correlated with neuronal cell birthday

1994 • 49 citations

PC3 potentiates NGF-induced differentiation and protects neurons from apoptosis

2002 • 48 citations