Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133

Synaptic Activity and the Construction of Cortical Circuits

1996 • 3,004 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms

1993 • 893 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Generic Signals and Specific Outcomes

1999 • 732 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Regulation of transcription factors by neuronal activity

2002 • 584 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons

1999 • 521 citations

A Dominant-Negative Inhibitor of CREB Reveals that It Is a General Mediator of Stimulus-Dependent Transcription of c-fos

1998 • 502 citations

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 • 495 citations

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

2001 • 466 citations

The Developing Synapse: Construction and Modulation of Synaptic Structures and Circuits

2002 • 453 citations

N-methyl-d-aspartate promotes the survival of cerebellar granule cells in culture

1988 • 437 citations

Induction of bcl-2 Expression by Phosphorylated CREB Proteins during B-Cell Activation and Rescue from Apoptosis

1996 • 410 citations

Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.

1994 • 370 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c- fos gene

1998 • 302 citations

Glutamate Acting at NMDA Receptors Stimulates Embryonic Cortical Neuronal Migration

1999 • 287 citations

GABA neurotransmission in the hypothalamus: developmental reversal from Ca2+ elevating to depressing

1995 • 272 citations

Phosphorylation of cAMP Response Element-Binding Protein in Hippocampal Neurons as a Protective Response after Exposure to GlutamateIn Vitroand IschemiaIn Vivo

2001 • 266 citations

CaM-kinases: modulators of synaptic plasticity

2000 • 232 citations

εPKC Is Required for the Induction of Tolerance by Ischemic and NMDA-Mediated Preconditioning in the Organotypic Hippocampal Slice

2003 • 211 citations

Nuclear and axonal localization of Ca2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex.

1991 • 206 citations

Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum

1996 • 195 citations

Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons

2000 • 190 citations

CREB Phosphorylation Promotes Nerve Cell Survival

1999 • 189 citations

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

2000 • 186 citations

Clustering of Gephyrin at GABAergic but Not Glutamatergic Synapses in Cultured Rat Hippocampal Neurons

1996 • 175 citations

N-methyl-D-aspartate receptor-mediated neuroprotection in cerebellar granule cells requires new RNA and protein synthesis.

1992 • 167 citations

Rat hippocampal neurons in culture: voltage-clamp analysis of inhibitory synaptic connections

1984 • 165 citations

Excitatory Actions of GABA Increase BDNF Expression via a MAPK-CREB–Dependent Mechanism—A Positive Feedback Circuit in Developing Neurons

2002 • 161 citations

Voltage-Gated Channels Block Nicotinic Regulation of CREB Phosphorylation and Gene Expression in Neurons

2001 • 157 citations

Phosphorylation and Activation of Ca2+-Calmodulin-dependent Protein Kinase IV by Ca2+-Calmodulin-dependent Protein Kinase Ia Kinase

1995 • 137 citations

Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum.

1992 • 131 citations

The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

1996 • 119 citations

Rapid onset of neuronal death induced by blockade of either axoplasmic transport or action potentials in afferent fibers during brain development

1992 • 112 citations

Persistent phosphorylation of cyclic amp responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain

1999 • 100 citations

CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region

2003 • 93 citations

Expression of activating transcription factor-2, serum response factor and cAMP/Ca response element binding protein in the adult rat brain following generalized seizures, nerve fibre lesion and ultraviolet irradiation

1997 • 92 citations

Properties of inhibitory and excitatory synapses between hippocampal neurons in very low density cultures

1994 • 87 citations

Patterned Vision Causes CRE-Mediated Gene Expression in the Visual Cortex through PKA and ERK

2003 • 85 citations

N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells.

1992 • 81 citations

Inducible cAMP Early Repressor, an Endogenous Antagonist of cAMP Responsive Element-Binding Protein, Evokes Neuronal ApoptosisIn Vitro

2003 • 74 citations

GABA_BReceptor-Mediated Inhibition of GABA_AReceptor Calcium Elevations in Developing Hypothalamic Neurons

1998 • 73 citations

Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-d-aspartate receptors

2003 • 73 citations

The effects of excitatory amino acids and their antagonists on the generation of motor activity in the isolated chick spinal cord

1987 • 60 citations

Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins

1999 • 57 citations

Embryonic hypothalamic expression of functional glutamate receptors

1995 • 51 citations

CRE‐mediated gene transcription in the peri‐infarct area after focal cerebral ischemia in mice

2003 • 42 citations

ROLE OF AFFERENTS IN THE DEVELOPMENT AND CELL SURVIVAL OF THE VERTEBRATE NERVOUS SYSTEM

1998 • 40 citations

Early synaptogenesis in vitro: Role of axon target distance

1998 • 31 citations

Phosphorylation of Cyclic Adenosine Monophosphate Response Element Binding Protein in Oligodendrocytes in the Corpus Callosum after Focal Cerebral Ischemia in the Rat

2001 • 27 citations

Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers.

1996 • 26 citations

Early synaptogenesis in vitro: Role of axon target distance

1998 • 24 citations

Mechanisms of cell death by deprivation of depolarizing conditions during cerebellar granule neurons maturation

2003 • 23 citations

BDNF gene transcripts in mesencephalic neurons and its differential regulation by NMDA

1998 • 23 citations

Activation of CA2+/calmodulin-dependent protein kinase IV in cultured rat hippocampal neurons

2000 • 19 citations