Postsynaptic Signaling and Plasticity Mechanisms

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

The molecular basis of CaMKII function in synaptic and behavioural memory

2002 • 1,855 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Synaptic Modification by Correlated Activity: Hebb's Postulate Revisited

2001 • 1,455 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

PSD-95 Involvement in Maturation of Excitatory Synapses

2000 • 1,238 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

2000 • 1,201 citations

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

2000 • 1,086 citations

Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

2000 • 1,076 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Dentritic spines : structure, dynamics and regulation

2001 • 915 citations

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

2001 • 898 citations

Ca ²⁺ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors

1999 • 836 citations

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

1996 • 835 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

Signal-Processing Machines at the Postsynaptic Density

2000 • 792 citations

The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal SynapsesIn Vitro

1999 • 780 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

2002 • 756 citations

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

2000 • 728 citations

Interaction with the NMDA receptor locks CaMKII in an active conformation

2001 • 695 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

2000 • 687 citations

NMDA Induces Long-Term Synaptic Depression and Dephosphorylation of the GluR1 Subunit of AMPA Receptors in Hippocampus

1998 • 664 citations

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

2001 • 657 citations

Calcium stores regulate the polarity and input specificity of synaptic modification

2000 • 630 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

2002 • 596 citations

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

1998 • 578 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Synaptic Strength Regulated by Palmitate Cycling on PSD-95

2002 • 547 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Molecular determinants of NMDA receptor internalization

2001 • 529 citations

PDZ domains in synapse assembly and signalling

2000 • 525 citations

A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses

2000 • 521 citations

Regulation of AMPA receptor lateral movements

2002 • 518 citations

Subunit-Specific NMDA Receptor Trafficking to Synapses

2002 • 503 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

2000 • 483 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

2000 • 463 citations

Postsynaptic organisation and regulation of excitatory synapses

2000 • 452 citations

Role of ampa receptor endocytosis in synaptic plasticity

2001 • 436 citations

Protein kinase C modulates NMDA receptor trafficking and gating

2001 • 418 citations

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

1998 • 415 citations

An NMDA Receptor ER Retention Signal Regulated by Phosphorylation and Alternative Splicing

2001 • 414 citations

Mobile NMDA Receptors at Hippocampal Synapses

2002 • 413 citations

Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology

2001 • 396 citations

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

1998 • 396 citations

Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP

2001 • 383 citations

Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins

2000 • 381 citations

The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis

2001 • 375 citations

Integration of calcium and RAS signalling

2002 • 375 citations

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

2001 • 361 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

A mouse model for the learning and memory deficits associated with neurofibromatosis type I

1997 • 352 citations

Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins

2000 • 352 citations

A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala

2001 • 339 citations

PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses

2000 • 328 citations

Roles of serine/threonine phosphatases in hippocampel synaptic plasticity

2001 • 327 citations

PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

2001 • 322 citations

Visualization of changes in presynaptic function during long-term synaptic plasticity

2001 • 315 citations

NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity

2001 • 299 citations

Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association

2000 • 295 citations

Ubiquitin and AP180 Regulate the Abundance of GLR-1 Glutamate Receptors at Postsynaptic Elements in C. elegans

2002 • 293 citations

Involvement of a Postsynaptic Protein Kinase A Substrate in the Expression of Homosynaptic Long-Term Depression

1998 • 287 citations

CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus

2001 • 272 citations

Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein

1999 • 260 citations

Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway

2001 • 259 citations

Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region

2002 • 254 citations

Postfusional regulation of cleft glutamate concentration during LTP at ‘silent synapses’

2000 • 247 citations

A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation

2001 • 226 citations

Regulation of Synaptic Strength by Protein Phosphatase 1

2001 • 220 citations

Bidirectional, Activity-Dependent Regulation of Glutamate Receptors in the Adult Hippocampus In Vivo

2000 • 217 citations

Regulation of GluR1 by the A-Kinase Anchoring Protein 79 (AKAP79) Signaling Complex Shares Properties with Long-Term Depression

2002 • 216 citations

Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.

2001 • 207 citations

AMPA Receptor Trafficking and the Control of Synaptic Transmission

2001 • 199 citations

Nitric oxide mediatesN-methyl-<scp>d</scp>-aspartate receptor-induced activation of p21^ras

1998 • 192 citations

Developmentally Regulated NMDA Receptor-Dependent Dephosphorylation of cAMP Response Element-Binding Protein (CREB) in Hippocampal Neurons

2000 • 190 citations

NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex

2002 • 189 citations

C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors

2000 • 184 citations

Densin-180 Forms a Ternary Complex with the α-Subunit of Ca²⁺/Calmodulin-Dependent Protein Kinase II and α-Actinin

2001 • 167 citations

Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II

2002 • 152 citations

Regulation of Long-Term Potentiation by H-Ras through NMDA Receptor Phosphorylation

2000 • 112 citations