Hsp70 Gene Transfer by Adeno-associated Virus Inhibits MPTP-Induced Nigrostriatal Degeneration in the Mouse Model of Parkinson Disease

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1998 • 5,063 citations

Parkinson's Disease

2003 • 5,061 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

2003 • 4,187 citations

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia

2003 • 2,591 citations

Protein degradation and protection against misfolded or damaged proteins

2003 • 2,022 citations

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2000 • 1,975 citations

Molecular Pathways of Neurodegeneration in Parkinson's Disease

2003 • 1,634 citations

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

2000 • 1,526 citations

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

2000 • 1,484 citations

Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

2002 • 1,220 citations

An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin

2001 • 1,048 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Heat-shock protein 70 antagonizes apoptosis-inducing factor

2001 • 846 citations

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70

1999 • 830 citations

DJ‐1 has a role in antioxidative stress to prevent cell death

2004 • 828 citations

Negative regulation of the Apaf-1 apoptosome by Hsp70

2000 • 819 citations

The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments

1996 • 742 citations

Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors

1998 • 691 citations

Understanding cell death in parkinson's disease

1998 • 678 citations

Characterization of Behavioral and Neurodegenerative Changes Following Partial Lesions of the Nigrostriatal Dopamine System Induced by Intrastriatal 6-Hydroxydopamine in the Rat

1998 • 648 citations

Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration

2003 • 634 citations

Animal models of Parkinson's disease

2002 • 580 citations

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

2002 • 569 citations

Genetic Suppression of Polyglutamine Toxicity in Drosophila

2000 • 562 citations

A Wide Variety of Mutations in the Parkin Gene Are Responsible for Autosomal Recessive Parkinsonism in Europe

1999 • 526 citations

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

2001 • 489 citations

In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining

1997 • 460 citations

Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.

1996 • 407 citations

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

2004 • 406 citations

Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

2000 • 405 citations

α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP

2000 • 379 citations

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

2001 • 360 citations

Caspase-9 Activation Results in Downstream Caspase-8 Activation and Bid Cleavage in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease

2001 • 310 citations

Protein Misfolding, Amyloid Formation, and Neurodegeneration

2002 • 306 citations

Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis

1998 • 289 citations

The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease.

2003 • 286 citations

The 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Mouse Model

2003 • 245 citations

Dopaminergic neuronal degeneration and motor impairments following axon terminal lesion by intrastriatal 6-hydroxydopamine in the rat

1996 • 240 citations

Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain

2003 • 239 citations

Are Ubiquitination Pathways Central to Parkinson's Disease?

2003 • 232 citations

Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutation

2003 • 232 citations

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

2001 • 223 citations

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

2003 • 212 citations

Chaperoning brain degeneration

2002 • 208 citations

Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease

2003 • 204 citations

Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease

2001 • 190 citations

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

2003 • 183 citations

Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins

2001 • 178 citations

Heat shock protein hsp70 overexpression confers resistance against nitric oxide

1996 • 163 citations

An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease

2001 • 162 citations

Parkin and the Molecular Pathways of Parkinson's Disease

2001 • 160 citations

Caspase-11 Mediates Inflammatory Dopaminergic Cell Death in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson's Disease

2004 • 137 citations

Analysis of heat-shock protein�70 gene polymorphisms and the risk of Parkinson?s disease

2004 • 132 citations

Extended analysis of path data from mutant mice using the public domain software Wintrack

2001 • 130 citations

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1

2003 • 129 citations

Regulation of Dopaminergic Loss by Fas in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease

2004 • 127 citations

Transduction Profiles of Recombinant Adeno-Associated Virus Vectors Derived from Serotypes 2 and 5 in the Nigrostriatal System of Rats

2004 • 98 citations

Pathways to Parkinsonism

2003 • 98 citations

Induction of heat shock protein 70 protects mesangial cells against oxidative injury

1999 • 53 citations

Discussion

1998 • 38 citations

Overview of the genetics of parkinsonism.

2003 • 34 citations