New Retinoid X Receptor Subtypes in Zebra Fish (Danio rerio) Differentially Modulate Transcription and Do Not Bind 9-cis Retinoic Acid

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

The Retinoids-Biology, Chemistry and Medicine

1994 • 987 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

1994 • 684 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.

1992 • 446 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish

1995 • 319 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.

1992 • 302 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.

1993 • 272 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

1994 • 251 citations

The t4 Activation Domain of the Thyroid Hormone Receptor Is Required for Release of a Putative Corepressor(s) Necessary for Transcriptional Silencing

1995 • 250 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.

1991 • 217 citations

Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.

1992 • 216 citations

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

1994 • 210 citations

Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism.

1993 • 185 citations

Interaction between retinoic acid and vitamin D signaling pathways.

1993 • 171 citations

A member of the RXR nuclear receptor family is expressed in neural-crest-derived cells of the developing chick peripheral nervous system

1991 • 163 citations

Multiple retinoid-responsive receptors in a single cell: families of retinoid "X" receptors and retinoic acid receptors in the Xenopus egg.

1992 • 147 citations

A zebrafish retinoic acid receptor expressed in the regenerating caudal fin

1994 • 135 citations

The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation

1993 • 132 citations

Functional Evidence for Ligand-Dependent Dissociation of Thyroid Hormone and Retinoic Acid Receptors from an Inhibitory Cellular Factor

1994 • 116 citations

Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid

1994 • 111 citations

Specificity and flexibility of vitamin D signaling. Modulation of the activation of natural vitamin D response elements by thyroid hormone.

1994 • 107 citations

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

1993 • 103 citations

Formation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching.

1993 • 99 citations

Mouse Retinoid X Receptor Contains a Separable Ligand-Binding and Transactivation Domain in Its E Region

1995 • 95 citations

Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90

1991 • 91 citations

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

1993 • 83 citations

The Ligand-Binding Domains of the Thyroid Hormone/Retinoid Receptor Gene Subfamily Function in Vivo To Mediate Heterodimerization, Gene Silencing, and Transactivation

1995 • 82 citations

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

1994 • 77 citations

Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.

1994 • 77 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

1994 • 72 citations

High affinity and specificity of dimeric binding of thyroid hormone receptors to DNA and their ligand-dependent dissociation.

1993 • 71 citations

The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene.

1994 • 68 citations

Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.

1994 • 66 citations

FTZ-F1β, a novel member of the Drosophila nuclear receptor family

1993 • 62 citations

Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer.

1994 • 61 citations

Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression.

1993 • 61 citations

RXR-dependent and RXR-independent transactivation by retinoic acid receptors

1993 • 58 citations

Ligand-dependent synergy of thyroid hormone and retinoid X receptors.

1992 • 53 citations

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.

1994 • 52 citations

Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor β

1992 • 43 citations

Protocols and Applications

2024 • 29 citations

9-cis-retinoic acid is a natural antagonist for the retinoic acid receptor response pathway

1993 • 29 citations

Specificity and Flexibility of Vitamin D Signaling

1994 • 26 citations

Structural and functional evidence for activation of a chick retinoid X receptor by eicosanoids

1992 • 17 citations

Deleted Work

1955 • 0 citations