Mechanisms for synergistic activation of thyroid hormone receptor and retinoid X receptor on different response elements.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.

1992 • 446 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

1992 • 389 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor.

1992 • 302 citations

Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.

1993 • 262 citations

Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.

1993 • 245 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor

1990 • 211 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor.

1991 • 163 citations

An everted repeat mediates retinoic acid induction of the gamma F-crystallin gene: evidence of a direct role for retinoids in lens development.

1993 • 157 citations

A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation

1993 • 119 citations

Cooperativity in transactivation between retinoic acid receptor and TFIID requires an activity analogous to E1A

1992 • 116 citations

Mouse Retinoid X Receptor Contains a Separable Ligand-Binding and Transactivation Domain in Its E Region

1995 • 95 citations

Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor

1993 • 92 citations

Thyroid hormone receptor functions as monomeric ligand-induced transcription factor on octameric half-sites. Consequences also for dimerization.

1994 • 77 citations

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

1994 • 77 citations

Conformational changes in chicken thyroid hormone receptor .alpha.1 induced by binding to ligand or to DNA

1993 • 69 citations

Retinoic acid-dependent transactivation of major histocompatibility complex class I promoters by the nuclear hormone receptor H-2RIIBP in undifferentiated embryonal carcinoma cells.

1992 • 64 citations

Oligomeric binding of T3 receptor is required for maximal T3 response.

1991 • 63 citations

Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.

1993 • 62 citations

Divergent effects of 9-cis-retinoic acid receptor on positive and negative thyroid hormone receptor-dependent gene expression.

1993 • 61 citations

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.

1994 • 52 citations

DNA bending by retinoid X receptor-containing retinoid and thyroid hormone receptor complexes.

1993 • 46 citations

Thyroid hormone receptor-induced bending of specific DNA sequences is modified by an accessory factor.

1993 • 43 citations

Homodimer and heterodimer DNA binding and transcriptional responsiveness to triiodothyronine (T3) and 9-cis-retinoic acid are determined by the number and order of high affinity half-sites in a T3 response element.

1994 • 28 citations

Nucleotide substitutions differentially affect direct repeat and palindromic thyroid hormone response elements

1994 • 15 citations