Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element

1989 • 507 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Two amino acids within the knuckle of the first zinc finger specify DNA response element activation by the glucocorticoid receptor

1989 • 358 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors

1992 • 323 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

1994 • 251 citations

A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter

1990 • 235 citations

Photocrosslinking of 5-Iodouracil-Substituted RNA and DNA to Proteins

1993 • 177 citations