Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*

1993 • 1,009 citations

The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily

1991 • 958 citations

Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

1993 • 936 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.

1992 • 829 citations

The Syndromes of Resistance to Thyroid Hormone*

1993 • 804 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Retinoic Acid Receptors and Cellular Retinoid Binding Proteins: Complex Interplay in Retinoid Signaling*

1994 • 514 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.

1993 • 380 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.

1992 • 325 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

FTZ-F1, a Steroid Hormone Receptor-like Protein Implicated in the Activation of fushi tarazu

1991 • 292 citations

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

1992 • 279 citations

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

1994 • 251 citations

Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.

1993 • 245 citations

A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter.

1991 • 240 citations

v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA

1990 • 236 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

COUP Orphan Receptors Are Negative Regulators of Retinoic Acid Response Pathways

1992 • 216 citations

Identification of two novel members oferbAsuperfamily by molecular cloning: the gene products of the two are highly related to each other

1988 • 212 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.

1993 • 193 citations

Mechanisms of transactivation by retinoic acid receptors

1993 • 156 citations

The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.

1994 • 142 citations

Orphan receptors: in search of a unifying hypothesis for activation.

1992 • 138 citations

Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR alpha and retinoic acid.

1992 • 135 citations

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

1990 • 134 citations

The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation

1993 • 132 citations

Functional domains and phosphorylation of the orphan receptor Nur77.

1993 • 128 citations

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

1994 • 125 citations

Regulation of Gene Expression by Vitamin A: The Role of Nuclear Retinoic Acid Receptors

1992 • 124 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

Domains regulating transcriptional activity of the inducible orphan receptor NGFI-B.

1992 • 110 citations

Chaperone functions of the heat shock proteins associated with steroid receptors

1994 • 108 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

COUP-TF acts as a competitive repressor for estrogen receptor-mediated activation of the mouse lactoferrin gene.

1993 • 105 citations

The COUP-TFs compose a family of functionally related transcription factors.

1991 • 103 citations

A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).

1993 • 103 citations

Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast

1992 • 103 citations

Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling.

1993 • 99 citations

Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90

1991 • 91 citations

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.

1993 • 86 citations

Transcriptional activation of the inducible nuclear receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

1993 • 78 citations

FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

1994 • 78 citations

Antagonism between Apolipoprotein AI Regulatory Protein 1, Ear3/COUP-TF, and Hepatocyte Nuclear Factor 4 Modulates Apolipoprotein CIII Gene Expression in Liver and Intestinal Cells

1992 • 71 citations

Thyroid hormone receptor transcriptional activity is potentially autoregulated by truncated forms of the receptor.

1992 • 63 citations

Functional analysis of the human estrogen receptor using a phenotypic transactivation assay in yeast

1992 • 60 citations

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.

1994 • 52 citations

A Dominant Negative Mutation of the Alpha Retinoic Acid Receptor Gene in a Retinoic Acid-Nonresponsive Embryonal Carcinoma Cell

1990 • 31 citations

Steroid receptors and orphan receptors in Drosophila development

1994 • 27 citations

A Conserved C-Terminal Sequence That Is Deleted in v-ErbA is Essential for the Biological Activities of c-ErbA (the Thyroid Hormone Receptor)

1993 • 25 citations

Repression by ARP-1 Sensitizes Apolipoprotein A1 Gene Responsiveness to RXRα and Retinoic Acid

1992 • 24 citations

Thyroid Hormone Receptor Transcriptional Activity Is Potentially Autoregulated by Truncated Forms of the Receptor

1992 • 18 citations

FTZ-F1-Related Orphan Receptors in Xenopus laevis: Transcriptional Regulators Differentially Expressed During Early Embryogenesis

1994 • 9 citations

Distinct Binding Determinants for 9-cis Retinoic Acid Are Located within AF-2 of Retinoic Acid Receptor α

1994 • 6 citations