Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

The human estrogen receptor has two independent nonacidic transcriptional activation functions

1989 • 1,066 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.

1992 • 480 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

cis-trans isomers of lycopene and β-carotene in human serum and tissues

1992 • 415 citations

Vitamin A and reproduction in rats

1964 • 409 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells.

1991 • 328 citations

Isolation of 3,4-didehydroretinoic acid, a novel morphogenetic signal in the chick wing bud

1990 • 252 citations

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways.

1991 • 217 citations

Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein.

1990 • 212 citations

Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli. Characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism.

1991 • 202 citations

Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.

1985 • 126 citations

Holocellular retinol binding protein as a substrate for microsomal retinal synthesis

1991 • 121 citations

Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of Cellular Retinol-Binding Protein (CRBP) and Cellular Retinoic Acid-Binding Protein (CRABP) in the pathway of retinoic acid homeostasis

1991 • 120 citations

Retinol metabolism in LLC-PK1 Cells. Characterization of retinoic acid synthesis by an established mammalian cell line.

1986 • 107 citations

The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon.

1989 • 107 citations

Terminal-group oxidation of retinol by mouse epidermis. Inhibition in vitro and in vivo

1987 • 105 citations

Bioavailability of a Natural Isomer Mixture as Compared with Synthetic all-trans-β-Carotene in Rats and Chicks

1989 • 103 citations

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

1989 • 100 citations

Vitamin A in Human Skin: I. Detection and Identification of Retinoids in Normal Epidermis

1982 • 93 citations

Retinoic acid and synthetic analogs differentially activate retinoic acid receptor dependent transcription

1990 • 86 citations

Characterization of the PML-RAR alpha chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation.

1992 • 65 citations

6′-Substituted naphthalene-2-car☐ylic acid analogs, a new class of retinoic acid receptor subtype-specific ligands

1991 • 65 citations

The β-carotene-rich alga Dunaliella bardawil as a source of retinol in a rat diet

1988 • 45 citations

NOTES: A Retinoic Acid-Responsive Element in the Apolipoprotein AI Gene Distinguishes between Two Different Retinoic Acid Response Pathways

1991 • 40 citations

Biosynthesis of 3-Dehydroretinol (Vitamin A2) from all-trans-Retinol (Vitamin A1) in Human Epidermis

1985 • 30 citations

The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity.

1987 • 29 citations

Identification of 3-dehydroretinol (vitamin A2) in mouse liver

1988 • 6 citations