Targeting insulin-like growth factor axis in hepatocellular carcinoma

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

Sorafenib in Advanced Hepatocellular Carcinoma

2008 • 11,718 citations

Cancer Statistics, 2008

2008 • 10,165 citations

Sorafenib in Advanced Hepatocellular Carcinoma

2008 • 5,675 citations

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

2008 • 5,494 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

2006 • 2,463 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005

2009 • 1,659 citations

Insulin-like growth factors and neoplasia

2004 • 1,452 citations

Normal growth and development in the absence of hepatic insulin-like growth factor I

1999 • 1,430 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

The insulin-like growth factor system and cancer

2003 • 1,099 citations

The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update

2003 • 948 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis

2007 • 835 citations

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

2000 • 805 citations

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

2006 • 735 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

In vivo antitumor activity of NVP-AEW541—A novel, potent, and selective inhibitor of the IGF-IR kinase

2004 • 544 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Insulin-like growth factors and cancer

2002 • 521 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Mouse Mutants Lacking the Type 2 IGF Receptor (IGF2R) Are Rescued from Perinatal Lethality inIgf2andIgf1rNull Backgrounds

1996 • 479 citations

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

1997 • 432 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Height, Leg Length, and Cancer Risk: A Systematic Review

2001 • 396 citations

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.

1996 • 365 citations

Identification of a family of low-affinity insulin-like growth factor binding proteins (IGFBPs): Characterization of connective tissue growth factor as a member of the IGFBP superfamily

1997 • 352 citations

IGF-I receptor signalling in transformation and differentiation

2001 • 332 citations

Quantitative Mass Spectrometry Identifies Insulin Signaling Targets in C. elegans

2007 • 324 citations

Insulin and its receptor: structure, function and evolution

2004 • 317 citations

The IRS-1 signaling system

1994 • 310 citations

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

2009 • 301 citations

Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells

2004 • 298 citations

Recombinant Human Insulin-Like Growth Factor I Increases Insulin Sensitivity and Improves Glycemic Control in Type II Diabetes

1996 • 283 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Phase II Study of the Anti–Insulin-Like Growth Factor Type 1 Receptor Antibody CP-751,871 in Combination With Paclitaxel and Carboplatin in Previously Untreated, Locally Advanced, or Metastatic Non–Small-Cell Lung Cancer

2009 • 259 citations

STRUCTURE AND EVOLUTION OF THE INSULIN GENE

1985 • 252 citations

Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.

1988 • 252 citations

The contradictions of the insulin-like growth factor 1 receptor

2000 • 236 citations

AKT activation up-regulates insulin-like growth factor-I receptor expression and promotes invasiveness of human pancreatic cancer cells

2001 • 230 citations

Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells.

1992 • 225 citations

IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage

2010 • 217 citations

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

1988 • 192 citations

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

2010 • 191 citations

Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth

2008 • 185 citations

In vitro and In vivo Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417

2006 • 179 citations

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model

2008 • 174 citations

Effect of a Null Mutation of the Insulin-Like Growth Factor I Receptor Gene on Growth and Transformation of Mouse Embryo Fibroblasts

1994 • 162 citations

The IGF axis and hepatocarcinogenesis

2001 • 159 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Fetal growth and subsequent risk of breast cancer: results from long term follow up of Swedish cohort

2003 • 154 citations

Insulin-like Growth Factor I and Leptin in Umbilical Cord Plasma and Infant Birth Size at Term

2002 • 148 citations

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo

2007 • 148 citations

Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling

2002 • 143 citations

Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer

2005 • 136 citations

Molecular Profiling of Human Hepatocellular Carcinoma Defines Mutually Exclusive Interferon Regulation and Insulin-Like Growth Factor II Overexpression

2004 • 130 citations

Growth Inhibition of Human Prostate Cancer Cells in Human Adult Bone Implanted into Nonobese Diabetic/Severe Combined Immunodeficient Mice by a Ligand-Specific Antibody to Human Insulin-Like Growth Factors

2004 • 127 citations

Clinical and Prognostic Implications of Plasma Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Patients With Hepatocellular Carcinoma

2011 • 123 citations

Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth.

1992 • 121 citations

A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors

2011 • 120 citations

Insulin receptor substrate 1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta1-induced apoptosis.

1996 • 119 citations

Global action against cancer

2003 • 119 citations

Dual IGF-I/II–Neutralizing Antibody MEDI-573 Potently Inhibits IGF Signaling and Tumor Growth

2011 • 118 citations

High Birthweight as a Predictor of Prostate Cancer Risk

1995 • 116 citations

Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect.

1998 • 104 citations

The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth

2006 • 104 citations

Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: Its relationship with hepatitis B virus antigen expression

1994 • 100 citations

Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital

1994 • 99 citations

The IRS-1 signaling system

1994 • 95 citations

Hepatitis C virus and hepatocarcinogenesis

2012 • 92 citations

Overexpression of the Human Insulinlike Growth Factor I Receptor Promotes Ligand-Dependent Neoplastic Transformation

1990 • 92 citations

Effects of Growth Hormone on Glucose Metabolism

1991 • 91 citations

Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

2000 • 91 citations

Overexpression of Insulin Receptor Substrate-2 in Human and Murine Hepatocellular Carcinoma

2005 • 90 citations

Transcripts of the insulin-like growth factors I and II in human hepatoma.

1989 • 88 citations

Insulin-Like Growth Factor I Receptor Signaling in Transformation by src Oncogenes

1997 • 88 citations

Role of insulin receptors and IGF receptors in growth and development

2000 • 85 citations

Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer

2008 • 84 citations

A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors

2007 • 82 citations

The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

1998 • 81 citations

Transforming Growth Factor-Beta Receptors and Mannose 6-Phosphate/Insulin-Like Growth Factor-II Receptor Expression in Human Hepatocellular Carcinoma

1995 • 74 citations

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and β-arrestin1

2007 • 73 citations

Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

2007 • 72 citations

The Role of Insulin Receptor Signaling in Zebrafish Embryogenesis

2008 • 66 citations

Analysis of insulin-like growth factor II (IGF-II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing in situ hybridization and imununocytochemistry

1991 • 65 citations

mTOR as a Target for Cancer Therapy

2004 • 63 citations

Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC)

1998 • 62 citations

Self-reported birth weight and subsequent risk of colorectal cancer.

2002 • 60 citations

Molecular Analysis of Non–Small Cell Lung Cancer Identifies Subsets with Different Sensitivity to Insulin-like Growth Factor I Receptor Inhibition

2010 • 60 citations

The molecular genetics of adrenocortical carcinoma

2007 • 59 citations

Analysis of the IGF Axis in Preneoplastic Hepatic Foci and Hepatocellular Neoplasms Developing after Low-Number Pancreatic Islet Transplantation into the Livers of Streptozotocin Diabetic Rats

2000 • 56 citations

Allelic-expression imbalance of the insulin-like growth factor 2 gene in hepatocellular carcinoma and underlying disease.

1996 • 55 citations

A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors

2008 • 55 citations

Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis

2003 • 54 citations

Insulin-like growth factor-I-induced migration of melanoma cells is mediated by interleukin-8 induction.

2002 • 54 citations

The Price of Independence

1997 • 52 citations

Hepatitis C Virus and Hepatocarcinogenesis

1999 • 52 citations

Altered transcriptional regulation of the insulin-like growth factor 2 gene in human hepatocellular carcinoma

1997 • 51 citations

Insulin-like growth factor II (IGF-II) secreted from HepG2 human hepatocellular carcinoma cells shows angiogenic activity

1998 • 49 citations

The expression of insulin-like growth factor binding proteins in human hepatocellular carcinoma.

2000 • 49 citations

Nutrition and Somatomedin XXIX: Molecular Regulation of IGFBP-1 in Hepatocyte Primary Culture

1992 • 42 citations

Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions

1993 • 39 citations

Reactivation of the maternally imprinted IGF2 allele in TGFα induced hepatocellular carcinomas in mice

1998 • 36 citations

Serum Insulin-Like Growth Factor-II and α-Fetoprotein as Tumor Markers of Hepatocellular Carcinoma

2003 • 35 citations

Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas.

1995 • 31 citations

Co-localisation of insulin-like growth factor II and the proliferation marker MIB1 in hepatocellular carcinoma cells.

1997 • 28 citations

Expression of insulin‐like growth factor II mRNA in hepatocellular carcinoma

1998 • 28 citations

AMP-activated protein kinase is essential for survival in chronic hypoxia

2008 • 24 citations

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

2008 • 24 citations

Characterization of insulin-like-growth factor II (IGF II) mRNA positive hepatic altered foci and IGF II expression in hepatocellular carcinoma during diethylnitrosamine-induced hepatocarcinogenesis in rats.

2005 • 21 citations

Differential promoter usage for insulin-like growth factor-II gene in Chinese hepatocellular carcinoma with hepatitis B virus infection

2006 • 19 citations

Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice

2002 • 15 citations

Down-regulation of insulin-like growth factor binding proteins and growth modulation in hepatoma cells by retinoic acid

1999 • 15 citations

NCIC-CTG MA14 Trial: Tamoxifen (tam) vs. tam + octreotide (oct) for adjuvant treatment of stage I or II postmenopausal breast cancer

2008 • 13 citations

The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy

2011 • 11 citations

Decreased expression of insulin-like growth factor binding protein related protein-1(IGFBP-rP1) gene inradiation-induced mouse hepatomas :

2001 • 1 citations