Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Baculovirus expression vectors: a laboratory manual.

1992 • 1,799 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Gain of function mutations in p53

1993 • 876 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in Southern Guangxi, China

1990 • 325 citations

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

1997 • 302 citations

The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 • 253 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

1988 • 192 citations

Accurate transcription initiation on a purified mouse β-globin DNA fragment in a cell-free system

1980 • 126 citations

Identification and initial characterization of a fourth leader exon and promoter of the human IGF-II gene

1990 • 91 citations

The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4

1998 • 81 citations

Human hepatitis B virus and hepatocellular carcinoma II. Experimental induction of hepatocellular carcinoma in tree shrews exposed to hepatitis B virus and aflatoxin B1

1996 • 58 citations

The Retinoblastoma Gene Product Regulates Sp1-Mediated Transcription

1992 • 55 citations

Apoptosis is induced by N-myc expression in hepatocytes, a frequent event in hepadnavirus oncogenesis, and is blocked by insulin-like growth factor II

1996 • 52 citations

Suitability ofLactococcus lactissubsp.lactisATCC 11454 as a protective culture for lightly preserved fish products

1996 • 46 citations

p53 Regulates Human Insulin-Like Growth Factor II Gene Expression through Active P4 Promoter in Rhabdomyosarcoma Cells

1998 • 45 citations

Insulin-like growth factor II blocks apoptosis of N-myc2-expressing woodchuck liver epithelial cells

1996 • 36 citations

Characterization of the P4 promoter region of the human insulin‐like growth factor II gene

1993 • 16 citations

Expression of p53 gene in hepatocellular carcinomas induced by aflatoxin B1 with or without human hepatitis B virus in tree shrews

1997 • 4 citations

From The Lancet

1991 • 3 citations

Malignant Hyperthermia Syndrome

1984 • 3 citations

Hemoglobinuria during General Anesthesia

1984 • 2 citations