A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

2000 • 15,583 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Elimination mechanisms of therapeutic monoclonal antibodies

2006 • 457 citations

Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 as Predictors of Advanced-Stage Prostate Cancer

2002 • 444 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

EWS/FLI-1 Silencing and Gene Profiling of Ewing Cells Reveal Downstream Oncogenic Pathways and a Crucial Role for Repression of Insulin-Like Growth Factor Binding Protein 3

2004 • 405 citations

Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective Study

2000 • 403 citations

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

2009 • 301 citations

Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 3, and risk of colorectal cancer: a prospective study in northern Sweden

2002 • 274 citations

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.

1996 • 225 citations

Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer

2008 • 224 citations

Serum Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, and Prostate-Specific Antigen as Predictors of Clinical Prostate Cancer

2000 • 220 citations

Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor.

1990 • 171 citations

Phase I, Pharmacokinetic and Pharmacodynamic Study of the Anti–Insulinlike Growth Factor Type 1 Receptor Monoclonal Antibody CP-751,871 in Patients With Multiple Myeloma

2008 • 165 citations

Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3).

1995 • 164 citations

The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer

2008 • 144 citations

Involvement of insulin-like growth factor-I in the control of glucose homeostasis

2006 • 133 citations

Insulin-like growth factors in human breast cancer

1998 • 120 citations

IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells

2008 • 120 citations

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer

2008 • 117 citations

Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein.

1991 • 90 citations

IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1

2005 • 79 citations

Increased Expression of Insulin Receptor Substrate-1 in Human Pancreatic Cancer

1996 • 76 citations

Loss of imprinting of IGF2 in Ewing's sarcoma.

1995 • 62 citations

Insulin-like growth factor 1 (IGF-1) receptors, IGF-1, and IGF-2 are expressed in primary human sarcomas.

1995 • 60 citations

A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors

2008 • 55 citations

Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines

1992 • 46 citations

A phase I study of q3W R1507, a human monoclonal antibody IGF-1R antagonist in patients with advanced cancer

2007 • 45 citations

Safety, pharmacokinetics and preliminary activity of the anti-IGF-IR antibody CP-751,871 in patients with sarcoma

2008 • 39 citations

Differential roles of SS18–SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth

2008 • 26 citations

214 POSTER Characterization of a recombinant, fully human monoclonal antibody directed against the human insulin-like growth factor-1 receptor

2006 • 15 citations

A phase I study of q3W R1507, a human monoclonal antibody IGF-1R (insulin-like growth factor receptor) antagonist in patients with advanced solid tumors

2007 • 10 citations