Reactivation of insulin-like growth factor II during hepatocarcinogenesis in transgenic mice suggests a role in malignant growth.

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

1989 • 528 citations

Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

1988 • 483 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human Serum

1978 • 384 citations

Signal transmission by the insulin-like growth factors

1989 • 380 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Developmental regulation of the rat insulin-like growth factor I receptor gene.

1989 • 338 citations

Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: isolation, chemical characterization, and some biological properties of forms I and II.

1976 • 319 citations

Increased levels of multiplication-stimulating activity, an insulin-like growth factor, in fetal rat serum.

1980 • 313 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

1990 • 259 citations

Oncogene-induced liver neoplasia in transgenic mice.

1989 • 249 citations

Rat insulin-like growth factor II gene

1986 • 192 citations

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis.

1988 • 192 citations

Transformation by v- sis Occurs by an Internal Autoactivation Mechanism

1989 • 171 citations

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

1989 • 169 citations

Serum Somatomedin Levels in Adults with Chronic Renal Failure: TheImportance of Measuring Insulin-Like Growth Factor I (IGF-I) and IGF-II in Acid-Chromatographed Uremic Serum∗

1986 • 168 citations

Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

1986 • 122 citations

Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriers

1988 • 98 citations

Insulin-Like Growth Factor Carrier Proteins in Neonatal and Adult Rat Serum Are Immunologically Different: Demonstration Using a New Radioimmunoassay for the Carrier Protein from BRL-3A Rat Liver Cells

1986 • 96 citations

Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.

1987 • 96 citations

Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.

1987 • 95 citations

Sequence of a Placental cDNA Encoding the Mouse Insulin-Like Growth Factor II Precursor

1986 • 93 citations

Purification and Characterization of a Unique High Molecular Weight Form of Insulin-Like Growth Factor II

1987 • 90 citations

Quantitative assay for albumin-producing liver cells after simian virus 40 transformation of rat hepatocytes maintained in chemically defined medium.

1984 • 83 citations

T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene.

1989 • 77 citations

Analysis of insulin-like growth factor II (IGF-II) expression in neoplastic nodules and hepatocellular carcinomas of woodchucks utilizing in situ hybridization and imununocytochemistry

1991 • 65 citations

Reactivation of rat insulin-like growth factor II gene during hepatocarcinogenesis

1988 • 49 citations

Synthesis of Insulin-Like Growth Factor II (IGF-II) in Fetal Rat Tissues: Translation of IGF-II Ribonucleic Acid and Processing of Pre-Pro-IGF-II*

1988 • 46 citations

Production of an insulin-like growth factor by osteosarcoma

1984 • 46 citations

Insulin-like Growth Factor II Stimulates Calcium Influx in Competent Balb/c 3T3 Cells Primed with Epidermal Growth Factor

1989 • 46 citations

Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice.

1991 • 45 citations

Cellular and Molecular Mechanisms of Hepatocarcinogenesis Associated with Hepadnavirus Infection

1991 • 42 citations

Effects of insulin-like growth factors on chick embryo hepatocytes

1985 • 39 citations