Growth Inhibition of Human Prostate Cancer Cells in Human Adult Bone Implanted into Nonobese Diabetic/Severe Combined Immunodeficient Mice by a Ligand-Specific Antibody to Human Insulin-Like Growth Factors

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Metastases in carcinoma.Analysis of 1000 autopsied cases

1950 • 1,853 citations

Metastatic patterns of prostate cancer: An autopsy study of 1,589 patients

2000 • 1,740 citations

The insulin-like growth factor system and cancer

2003 • 1,099 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Insulin-like growth factors and cancer

1992 • 622 citations

The EGFR as a target for anticancer therapy—focus on cetuximab

2001 • 540 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Osteoprotegerin inhibits prostate cancer–induced osteoclastogenesis and prevents prostate tumor growth in the bone

2001 • 453 citations

Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.

2002 • 371 citations

Insulin-like growth factor physiology and cancer risk

2000 • 299 citations

The IGF-I Receptor in Cancer Research

1999 • 295 citations

Establishment of two human prostate cancer cell lines derived from a single bone metastasis.

1997 • 262 citations

Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3).

1993 • 247 citations

Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.

1996 • 239 citations

Osteolytic bone metastasis in breast cancer

1994 • 238 citations

Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant.

1994 • 195 citations

Morphometric Evidence for Bone Resorption and Replacement in Prostate Cancer

1991 • 192 citations

Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

1982 • 152 citations

Matrix Metalloproteinase-7 Facilitates Insulin-Like Growth Factor Bioavailability through Its Proteinase Activity on Insulin-Like Growth Factor Binding Protein 3

2004 • 151 citations

Estradiol stimulates invitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106

1989 • 138 citations

Prostate cancer cells induce osteoblast differentiation through a Cbfa1-dependent pathway.

2001 • 133 citations

Establishment of a novel species- and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone.

2001 • 111 citations

Bisphosphonates in prostate carcinoma

1997 • 107 citations

Prognostic Factors in Survival Free of Progression After Androgen Deprivation Therapy for Treatment of Prostate Cancer

1989 • 107 citations

Relationship between alpha subunit ligand occupancy and beta subunit autophosphorylation in insulin/insulin-like growth factor-1 hybrid receptors.

1993 • 105 citations

Insulin‐like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3

2001 • 105 citations

Bone metastases: improving the therapeutic index.

1994 • 89 citations

Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.

1989 • 88 citations

Bisphosphonates in prostate carcinoma

1997 • 88 citations

Preliminary results of the use of urinary excretion of pyridinium crosslinks for monitoring metastatic bone disease

1992 • 71 citations

Resorbing bone stimulates tumor cell growth. A role for the host microenvironment in bone metastasis.

1986 • 67 citations

Pyridinium cross‐links as urinary markers of bone metastases in patients with prostate cancer

1996 • 67 citations

Patterns of Bone Metastasis and their Prognostic Significance in Patients with Carcinoma of the Prostate

1993 • 63 citations

The Importance of Prognostic Factors in Advanced Prostate Cancer

1990 • 61 citations

Bone metabolic markers in bone metastases

1995 • 52 citations

Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors.

2002 • 44 citations

Prostate-Specific Antigen Induces Osteoplastic Changes by an Autonomous Mechanism

2001 • 36 citations

The role of the insulin-like growth factor receptor, the insulin receptor substrate and PTEN in human prostate cancer progression

2002 • 24 citations

Inhibition of vascular endothelial growth factor in the treatment of solid tumors

2002 • 24 citations