Dynamics of Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1998 • 2,427 citations

Regulation of angiogenesis by hypoxia: role of the HIF system

2003 • 2,404 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

1999 • 2,168 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 • 1,272 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

1997 • 1,057 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Tumor microenvironmental physiology and its implications for radiation oncology

2004 • 915 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

The Role of Hypoxia-Induced Factors in Tumor Progression

2004 • 809 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression

2000 • 641 citations

Hypoxic fractions of solid tumors: Experimental techniques, methods of analysis, and a survey of existing data

1984 • 610 citations

Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer.

2001 • 597 citations

Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients

1996 • 563 citations

Overexpression of glut-1 glucose transporter in human breast cancer an immunohistochemical study

1993 • 563 citations

Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome

1999 • 543 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

Hypoxic gene expression and metastasis

2004 • 470 citations

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

2001 • 456 citations

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress

2004 • 427 citations

Modification of hypoxia-induced radioresistance in tumors by the use of oxygen and sensitizers

1996 • 424 citations

Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy.

2005 • 394 citations

SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells

1986 • 391 citations

Overexpression of glut1 and glut3 in stage I nonsmall cell lung carcinoma is Associated with poor survival

1997 • 384 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 366 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.

1996 • 348 citations

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

2002 • 343 citations

Biological consequences of tumor hypoxia

2001 • 343 citations

Microenvironment-induced cancer metastasis

2000 • 335 citations

GLUT1 glucose transporter expression in colorectal carcinoma

1998 • 323 citations

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

1977 • 321 citations

Pimonidazole: A Novel Hypoxia Marker for Complementary Study of Tumor Hypoxia and Cell Proliferation in Cervical Carcinoma

1998 • 320 citations

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.

2001 • 320 citations

A marker for hypoxic cells in tumours with potential clinical applicability

1981 • 309 citations

Comparisons among Pimonidazole Binding, Oxygen Electrode Measurements, and Radiation Response in C3H Mouse Tumors

1999 • 299 citations

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

1972 • 296 citations

Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver

1995 • 296 citations

Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

2002 • 289 citations

Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography

1995 • 284 citations

Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers

2003 • 271 citations

Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial

2005 • 268 citations

Acute hypoxia in tumors: Implications for modifiers of radiation effects

1986 • 267 citations

Prognostic significance of tumor oxygenation in humans

2003 • 258 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 234 citations

RADIOTHERAPY AND HYPERBARIC OXYGEN IN HEAD AND NECK CANCER

1977 • 229 citations

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.

1993 • 223 citations

Assessment of tumor oxygenation by electron paramagnetic resonance: principles and applications

2004 • 221 citations

GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding

2003 • 216 citations

Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas.

2003 • 210 citations

Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding

2004 • 208 citations

[18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors

2003 • 206 citations

Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.

2001 • 205 citations

Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays

1997 • 201 citations

Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.

2001 • 199 citations

Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids

1995 • 197 citations

Expression of hypoxia-inducible factor-1α in oligodendrogliomas

2001 • 192 citations

Detection of hypoxia in human squamous cell carcinoma by EF5 binding.

2000 • 188 citations

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

1983 • 187 citations

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia

1999 • 183 citations

Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity

1995 • 181 citations

Hypoxia as a target for combined modality treatments

2002 • 180 citations

Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer

2004 • 174 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

Characterization of Radiolabeled Fluoromisonidazole as a Probe for Hypoxic Cells

1987 • 172 citations

Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells.

1987 • 168 citations

Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays

1998 • 167 citations

Microvascular studies on the origins of perfusion-limited hypoxia.

1996 • 162 citations

Expression of glucose transporters in head‐and‐neck tumors

1994 • 159 citations

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

2004 • 156 citations

Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia

1986 • 155 citations

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours

1987 • 150 citations

Establishing a Link between Oncogenes and Tumor Angiogenesis

1998 • 148 citations

HIF-1: master and commander of the hypoxic world

2004 • 147 citations

Effect of Nicotinamide on the Microregional Heterogeneity of Oxygen Delivery Within a Murine Tumor

1990 • 144 citations

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

2003 • 143 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

A Factor of Importance in the Radio Sensitivity of Tumours

1936 • 140 citations

Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.

2002 • 139 citations

Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent

2005 • 139 citations

Identification of nonproliferating but viable hypoxic tumor cells in vivo.

1998 • 139 citations

Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumours

1985 • 137 citations

Measuring Tumor Hypoxia.

1996 • 131 citations

Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas

2002 • 128 citations

Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis

2000 • 126 citations

Endogenous Markers of Tumor Hypoxia

2003 • 123 citations

Hypoxic Heterogeneity in Human Tumors

2001 • 122 citations

Quantifying Transient Hypoxia in Human Tumor Xenografts by Flow Cytometry

2004 • 121 citations

Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells

2004 • 120 citations

The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer

2002 • 119 citations

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]

1995 • 118 citations

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

2002 • 117 citations

Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas.

2003 • 116 citations

Influence of oxygen concentration and pH on expression of hypoxia induced genes

2005 • 113 citations

Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours

1988 • 111 citations

Hyperbaric Oxygen and Radiotherapy

2005 • 111 citations

Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer

1998 • 111 citations

Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules

1990 • 111 citations

Reporter gene imaging: potential impact on therapy

2005 • 110 citations

Functional imaging of intratumoral hypoxia

2004 • 110 citations

Non-invasive determination of tumor oxygen tension and local variation with growth

1994 • 107 citations

Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: monitoring by EPR and MRI

2000 • 107 citations

Measuring tumor hypoxia

1996 • 104 citations

Changes in oxygenation of intracranial tumors with carbogen: A BOLD MRI and EPR oximetry study

2002 • 100 citations

2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.

1996 • 99 citations

Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation.

1995 • 99 citations

The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON

2006 • 97 citations

Non-Invasive PET and Spect Imaging of Tissue Hypoxia Using Isotopically Labeled 2-Nitroimidazoles

2003 • 95 citations

Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas

2000 • 93 citations

The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations

1984 • 93 citations

Changes in Blood Perfusion and Hypoxia after Irradiation of a Human Squamous Cell Carcinoma Xenograft Tumor Line

2000 • 92 citations

Use of 2-nitroimidazoles as bioreductive markers for tumour hypoxia.

1998 • 92 citations

Hypoxic cell turnover in different solid tumor lines

2005 • 91 citations

Measurement of Tumor Oxygenation: A Comparison between Polarographic Needle Electrodes and a Time-Resolved Luminescence-Based Optical Sensor

1997 • 91 citations

Changes in tumor hypoxia measured with a double hypoxic marker technique

2000 • 91 citations

Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma

2001 • 90 citations

Early reoxygenation in tumors after irradiation: Determining factors and consequences for radiotherapy regimens using daily multiple fractions

2005 • 88 citations

Hypoxia-inducible factor-1alpha is an intrinsic marker for hypoxia in cervical cancer xenografts.

2001 • 88 citations

Comparison of the biodistribution of two hypoxia markers [ 18 F]FETNIM and [ 18 F]FMISO in an experimental mammary carcinoma

2004 • 88 citations

Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix

2006 • 87 citations

Use of a carbocyanine dye as a marker of functional vasculature in murine tumours

1989 • 83 citations

Detection of Hypoxic cells in a Murine Tumour With the Use of the Comet Assay

1992 • 82 citations

Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection

2004 • 82 citations

Cellular reaction to hypoxia: sensing and responding to an adverse environment

2004 • 79 citations

Characterization of carbonic anhydrase IX (CA IX) as an endogenous marker of chronic hypoxia in live human tumor cells

2005 • 78 citations

Covalent binding of a fluorinated 2-nitroimidazole to emt-6 tumors in Balb/C mice: detection by f-19 nuclear magnetic resonance at 2.35 T

1986 • 78 citations

Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion

1994 • 77 citations

Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse

1995 • 74 citations

Measurement of Tumor Oxygenation:In VivoComparison of a Luminescence Fiber-optic Sensor and a Polarographic Electrode in the P22 Tumor

2001 • 74 citations

Semiquantitative immunohistochemical analysis for hypoxia in human tumors

2001 • 74 citations

Relationship between radiobiological hypoxia in tumors and electrode measurements of tumor oxygenation

1994 • 74 citations

Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection

1991 • 73 citations

Microregional Expression of Glucose Transporter-1 and Oxygenation Status: Lack of Correlation in Locally Advanced Cervical Cancers

2005 • 72 citations

Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label

1985 • 72 citations

Plateau Phase in Growth Induced by Hypoxia

1973 • 70 citations

Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model

2001 • 69 citations

Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide

1999 • 69 citations

Proliferation kinetics of endothelial and tumour cells in three mouse mammary carcinomas

1982 • 69 citations

Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.

1996 • 68 citations

A novel technique for measuring human tissue pO2 at the cellular level

1986 • 67 citations

Pharmacokinetics of EF5 [2-(2-nitro-1- H -imidazol-1-yl)- N -(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles

2001 • 67 citations

Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival.

2001 • 66 citations

Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

1987 • 66 citations

Longevity of Pimonidazole Adducts in Spontaneous Canine Tumors as an Estimate of Hypoxic Cell Lifetime

1997 • 65 citations

A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.

2000 • 64 citations

Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas

2004 • 63 citations

Contribution of Transient Blood Flow to Tumour Hypoxia in Mice

1995 • 63 citations

Dynamics of Hypoxia, Proliferation and Apoptosis after Irradiation in a Murine Tumor Model

2006 • 62 citations

Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: In vitro and xenograft studies

2003 • 62 citations

Measuring Hypoxia in Solid Tumours&Is There a Gold Standard?

2001 • 62 citations

Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts

1998 • 62 citations

Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours

1990 • 61 citations

PET and PET/CT studies of tumor tissue oxygenation.

2006 • 61 citations

Glutathione conjugates of misonidazole

1983 • 60 citations

EF5 binding and clinical outcome in human soft tissue sarcomas

2006 • 59 citations

Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines

2005 • 59 citations

Assessment of Hypoxia in Experimental Mice Tumours by [ 18 F] Fluoromisonidazole PET and pO 2 Electrode Measurements

2002 • 59 citations

Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: Correlation with BOLD MRI

2002 • 58 citations

Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts

2001 • 57 citations

The lifetime of hypoxic human tumor cells

1998 • 56 citations

Tumor-line specific pO2 fluctuations in human melanoma xenografts

2004 • 56 citations

Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode

2000 • 56 citations

Distribution of the hypoxia marker CCI-103F in canine tumors

1994 • 54 citations

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

1994 • 54 citations

Clostridium spores for tumor-specific drug delivery

2002 • 54 citations

Reoxygenation after single irradiation in rodent tumors of different types and sizes

1996 • 53 citations

HIF-1’s Relationship to Oxygen: Simple yet Sophisticated

2004 • 52 citations

The Effect of Hypoxia on the Generation Time of Mammalian Cells

1973 • 51 citations

Radiation sensitization with redox modulators: A promising approach

2006 • 49 citations

Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes

2000 • 49 citations

Oxygenation and reoxygenation in 'sandwich' tumours.

1977 • 45 citations

Optical Sensor-Based Oxygen Tension Measurements Correspond with Hypoxia Marker Binding in Three Human Tumor Xenograft Lines

2000 • 43 citations

Prognostic value of glucose transporter 1 expression in patients with hypopharyngeal carcinoma.

2003 • 43 citations

Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo

1998 • 43 citations

Measurement of oxygen tension in tumours by time-resolved fluorescence.

1996 • 40 citations

The relationship between proliferative and oxygenation status in spontaneous canine tumors

1993 • 40 citations

Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling

2004 • 39 citations

In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors

2003 • 38 citations

Effects of nicotinamide and carbogen in different murine colon carcinomas: Immunohistochemical analysis of vascular architecture and microenvironmental parameters

2004 • 36 citations

A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker

2005 • 35 citations

Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature

2005 • 32 citations

True

2000 • 32 citations

BOLD contrast fMRI of whole rodent tumour during air or carbogen breathing using echo-planar imaging at 1.5 T

2001 • 30 citations

Irradiation combined with SU5416: Microvascular changes and growth delay in a human xenograft glioblastoma tumor line

2005 • 29 citations

Simultaneous triple staining for hypoxia, proliferation, and DNA content in murine tumours

1995 • 28 citations

ELISA quantification of CCI-103F binding in canine tumors prior to and during irradiation

1994 • 28 citations

Evaluation of a Fluorinated 2-Nitroimidazole Binding to Hypoxic Cells in Tumor-Bearing Rats by 19 F Magnetic Resonance Spectroscopy and Immunohistochemistry

1992 • 27 citations

Tumour blood flow influences combined radiation and doxorubicin treatments

1997 • 27 citations

Development of an elisa for the detection of 2-nitroimidazole hypoxia markers bound to tumor tissue

1992 • 25 citations

Dynamic Measurements of Hexafluoromisonidazole (CCI-103F) Retention in Mouse Tumours by¹H/¹⁹F Magnetic Resonance Spectroscopy

1990 • 25 citations

Oxygen-modifying treatment with ARCON reduces the prognostic significance of hemoglobin in squamous cell carcinoma of the head and neck

2005 • 23 citations

Distribution of pimonidazole and RSU 1069 in tumour and normal tissues

1990 • 22 citations

Patterns of proliferation related to vasculature in human head-and-neck carcinomas before and after transplantation in nude mice

2001 • 21 citations

Oxygenation and blood flow in tumors treated with hydralazine: Evaluation with a novel luminescence-based fiber-optic sensor

2002 • 21 citations

Characterization of a carbocyanine derivative as a fluorescent penetration probe

1987 • 20 citations

Survival of cells in anoxia

1968 • 17 citations

Pharmacokinetics and binding of the bioreductive probe for hypoxia, NITP: effect of route of administration

1995 • 16 citations

Some effects of anaerobiosis on the growth and metabolism of HeLa cells

1963 • 15 citations

Regioselective formation of a misonidazole-glutathione conjugate as a function of pH during chemical reduction

1988 • 15 citations

A dual hypoxic marker technique for measuring oxygenation change within individual tumors

1998 • 13 citations

A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice

1986 • 10 citations

The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799

1985 • 9 citations

Measurement of Hypoxia in Vivo Using A 2-Nitromidazole (NITP)

1997 • 8 citations

Deleted Work

1955 • 0 citations