Tumor microenvironmental physiology and its implications for radiation oncology

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects

2001 • 2,558 citations

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

1953 • 2,102 citations

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

1988 • 1,755 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

2000 • 786 citations

Causes and consequences of tumour acidity and implications for treatment

2000 • 746 citations

Are cancer cells acidic?

1991 • 576 citations

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

2001 • 534 citations

Treatment Resistance of Solid Tumors

2001 • 533 citations

Tumor Hypoxia and Malignant Progression

2004 • 464 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Microenvironment-induced cancer metastasis

2000 • 335 citations

Hypoxic cervical cancers with low apoptotic index are highly aggressive.

1999 • 328 citations

The hypoxic tumour microenvironment and metastatic progression.

2003 • 326 citations

3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon

2001 • 297 citations

Causes and Effects of Heterogeneous Perfusion in Tumors

1999 • 262 citations

Prognostic significance of tumor oxygenation in humans

2003 • 258 citations

Correlation of high lactate levels in head and neck tumors with incidence of metastasis.

1997 • 246 citations

Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas

2000 • 214 citations

Hypoxia in Breast Cancer: Pathogenesis, Characterization and Biological/Therapeutic Implications

2002 • 199 citations

Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH.

2000 • 195 citations

Tumor hypoxia in pelvic recurrences of cervical cancer

1998 • 169 citations

Hypoxic stress proteins: Survival of the fittest

1996 • 161 citations

Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance.

2000 • 156 citations

Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion.

1996 • 150 citations

Blood Perfusion and Microenvironment of Human Tumors

2000 • 127 citations

Endogenous Markers of Tumor Hypoxia

2003 • 123 citations

Mutagenesis induced by the tumor microenvironment

1998 • 119 citations

Oxygenation Status of Gynecologic Tumors: What is the Optimal Hemoglobin Level?

2002 • 114 citations

Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers.

2003 • 105 citations

Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH

2000 • 102 citations

Metabolic classification of human rectal adenocarcinomas: a novel guideline for clinical oncologists?

2003 • 97 citations

Lack of Correlation between Expression of HIF-1α Protein and Oxygenation Status in Identical Tissue Areas of Squamous Cell Carcinomas of the Uterine Cervix

2004 • 91 citations

Hypoxia in Breast Cancer

2006 • 81 citations

New non-angiogenesis dependent pathways for tumour growth

2003 • 59 citations

Physiological properties of malignant tumours

1992 • 56 citations

The vascular network of tumours — what is it not for?

2003 • 55 citations

Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total P_i

1994 • 50 citations

The Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity

2001 • 36 citations

Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis

2003 • 34 citations

Tumor Microenvironment and Hemorheological Abnormalities

2003 • 31 citations

O2 extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues

2003 • 30 citations

Blood flow and metabolic microenvironment of brain tumors

1994 • 28 citations

Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

2008 • 22 citations

Evidence for and Against Hypoxia as the Primary Cause of Tumor Aggressiveness

2003 • 14 citations

Tumor hypoxia and therapeutic resistance

2008 • 14 citations

Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

2002 • 13 citations

The tumor microenvironment and effects of hypoxia modification

2000 • 3 citations