Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label

A marker for hypoxic cells in tumours with potential clinical applicability

1981 • 309 citations

Radiation response of multicell spheroids--an in vitro tumour model.

1976 • 236 citations

Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.

1983 • 187 citations

Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

1980 • 161 citations

A Thin-Film Culturing Technique Allowing Rapid Gas-Liquid Equilibration (6 Sec) with No Toxicity to Mammalian Cells

1984 • 88 citations

The effect on the Km for radiosensitization at 0 degree C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation sensitizing agent misonidazole or oxygen.

1984 • 83 citations

Binding of 14C-misonidazole to hypoxic cells in V79 spheroids

1982 • 64 citations

Metabolism induced binding of 4C-misonidazole to hypoxic cells: Kinetic dependence on oxygen concentration and misonidazole concentration

1984 • 62 citations

Fluorescent nitroheterocycles for identifying hypoxic cells.

1983 • 60 citations

Glutathione conjugates of misonidazole

1983 • 60 citations

Studies on the action of nitroimidazole drugs

1983 • 59 citations

Reductive fragmentation of 2-nitroimidazoles in the presence of nitroreductases—glyoxal formation from misonidazole

1983 • 42 citations

Binding of misonidazole to V79 spheroids and fragments of dunning rat prostatic and human colon carcinomas in vitro: Diffusion of oxygen and reactive metabolites

1984 • 42 citations

Synthesis and In vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole

1983 • 37 citations

The Radiation Reduction of Misonidazole

1981 • 37 citations

Binding of misonidazole to EMT6 AND V79 spheroids

1982 • 32 citations

The radiation response of hypoxic cells in EMT6 spheroids in suspension culture does model data from EMT6 tumors.

1983 • 31 citations

Reductive fragmentation of 2-nitroimidazoles: Amines and aldehydes

1984 • 28 citations

Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells

1982 • 26 citations

Metabolism and excretion of [3H]misonidazole by hypoxic rat liver

1984 • 24 citations

Bromomisonidazole: Synthesis and Characterization of a New Radiosensitizer

1982 • 24 citations

Nitroreductase-induced binding of nitroaromatic radiosensitizers to unsaturated lipids

1981 • 21 citations

The Radiation Response of Hypoxic Cells in EMT6 Spheroids in Suspension Culture Does Model Data from EMT6 Tumors

1983 • 20 citations

Reductive activation of nitroaromatics and enzyme inhibition: Misonidazole and xanthine oxidase

1982 • 3 citations