Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

A marker for hypoxic cells in tumours with potential clinical applicability

1981 • 309 citations

The Phenomenon of Reoxygenation and Its Implications for Fractionated Radiotherapy

1972 • 296 citations

Hypoxic Sensitizers — Implications for Radiation Therapy

1979 • 209 citations

Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia

1989 • 194 citations

Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

1980 • 161 citations

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours

1987 • 150 citations

Intercapillary distance measurement as an indicator of hypoxia in carcinoma of the cervix uteri

1986 • 130 citations

Oxygen Diffusion Distance and Development of Necrosis in Multicell Spheroids

1979 • 121 citations

Rate of oxygen loss from arterioles is an order of magnitude higher than expected

1989 • 87 citations

Hypoxic cells as specific drug targets for chemotherapy.

1987 • 87 citations

Misonidazole and other hypoxia markers: Metabolism and applications

1986 • 81 citations

Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo

1989 • 74 citations

Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: Evidence that a side-chain label is bound as efficiently as a ring label

1985 • 72 citations

Proliferation kinetics of endothelial and tumour cells in three mouse mammary carcinomas

1982 • 69 citations

A novel technique for measuring human tissue pO2 at the cellular level

1986 • 67 citations

Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

1987 • 66 citations

Glutathione conjugates of misonidazole

1983 • 60 citations

Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses

1979 • 56 citations

Is misonidazole binding to mouse tissues a measure of cellular pO2?

1987 • 44 citations

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

1988 • 43 citations

Binding of misonidazole to V79 spheroids and fragments of dunning rat prostatic and human colon carcinomas in vitro: Diffusion of oxygen and reactive metabolites

1984 • 42 citations

Quantitation and Estimation of Lymphocyte Subsets in Tissue Section: Comparison with Flow Cytometry

1987 • 40 citations

Reductive metabolism of niridazole by adult Schistosoma mansoni. Correlation with covalent drug binding to parasite macromolecules.

1983 • 39 citations

The growth and cell population kinetics of spontaneous tumours in domestic animals.

1969 • 37 citations

Synthesis and In vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole

1983 • 37 citations

Manual of immunoperoxidase techniques

1983 • 37 citations

The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system

1984 • 34 citations

Nitrofuran induced mutagenesis and error prone repair in Escherichia coli

1980 • 26 citations

Identification of a hypoxic population of bone marrow cells

1983 • 26 citations

NAD(P)H nitroblue tetrazolium reductase levels in apparently normoxic tissues: a histochemical study correlating enzyme activity with binding of radiolabelled misonidazole

1990 • 24 citations

Hypoxia-enhanced reduction and covalent binding of [2-3H]misonidazole in the perfused rat liver

1984 • 19 citations

Metabolic binding of misonidazole to mouse tissues

1989 • 15 citations

Regioselective formation of a misonidazole-glutathione conjugate as a function of pH during chemical reduction

1988 • 15 citations

Quantitation of hypoxia in multicellular spheroids by video image analysis

1989 • 15 citations

Pharmacokinetic and anti-tumor studies with the radiosensitizer misonidazole in dogs with spontaneous fibrosarcomas.

1982 • 11 citations

The pharmacokinetics in mice and dogs of nitroimidazole radiosensitizers and chemosensitizers more lipophilic than misonidazole

1982 • 8 citations