Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

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Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

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Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

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Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

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Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

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Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

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Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

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Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

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A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

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Acute hypoxia in tumors: Implications for modifiers of radiation effects

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Correlation of high lactate levels in head and neck tumors with incidence of metastasis.

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Correlation of high lactate levels in human cervical cancer with incidence of metastasis.

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Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix

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Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia

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Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors

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Tumor hypoxia in pelvic recurrences of cervical cancer

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Intracapillary oxyhemoglobin saturation of malignant tumors in humans

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Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

1992 • 103 citations

Geographical mapping of metabolites in biological tissue with quantitative bioluminescence and single photon imaging

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High spatial resolution readout of 3-D metabolic organ structure: An automated, low-temperature redox ratio-scanning instrument

1985 • 92 citations

Localization of tumors and evaluation of their state of oxygenation by phosphorescence imaging.

1992 • 92 citations

Modulation of c-Myc activity and apoptosis in vivo.

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Perivascular Oxygen Tensions in a Transplantable Mammary Tumor Growing in a Dorsal Flap Window Chamber

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Microcirculatory Blood Flow, Capillary Morphology, and Local Oxygen Pressure of the Hamster Amelanotic Melanoma A-Mel-3<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

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A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.

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Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours

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Arteriolar oxygenation in tumour and subcutaneous arterioles: effects of inspired air oxygen content.

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Glucose Diffusion Coefficients Determined from Concentration Profiles in Emt6 Tumor Spheroids Incubated in Radioactively Labeled L-Glucose

1994 • 37 citations

Intravascular oxygen distribution in subcutaneous 9L tumors and radiation sensitivity

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Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration

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Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network

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Mapping and quantification of biomolecules in tumor biopsies using bioluminescence

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