Effects of nicotinamide and carbogen in different murine colon carcinomas: Immunohistochemical analysis of vascular architecture and microenvironmental parameters
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References (87)
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
1955 • 2,174 citations
Acid pH in tumors and its potential for therapeutic exploitation.
1989 • 1,633 citations
Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.
1991 • 950 citations
Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis
2000 • 943 citations
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
1996 • 930 citations
Observations on the carbohydrate metabolism of tumours
1929 • 821 citations
Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix
1993 • 811 citations
Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
1979 • 523 citations
DOES BREAST MILK PROTECT AGAINST SEPTICÆMIA IN THE NEWBORN ?
1971 • 515 citations
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.
2001 • 456 citations
Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma
2001 • 425 citations
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
1986 • 391 citations
Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer
2002 • 366 citations
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
2002 • 354 citations
Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies
2000 • 345 citations
Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
2002 • 343 citations
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy.
2001 • 309 citations
Comparisons among Pimonidazole Binding, Oxygen Electrode Measurements, and Radiation Response in C3H Mouse Tumors
1999 • 299 citations
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver
1995 • 296 citations
Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors
1995 • 268 citations
Development of a hypoxia-responsive vector for tumor-specific gene therapy
2000 • 262 citations
ARCON: a novel biology-based approach in radiotherapy
2002 • 250 citations
Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
2001 • 222 citations
GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
2003 • 216 citations
The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes
1993 • 206 citations
Oxygenation of Human Tumors
2000 • 189 citations
Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line.
1995 • 171 citations
Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours
1987 • 150 citations
High-Pressure Oxygen and Radiotherapy
1959 • 147 citations
Effect of Nicotinamide on the Microregional Heterogeneity of Oxygen Delivery Within a Murine Tumor
1990 • 144 citations
Identification of nonproliferating but viable hypoxic tumor cells in vivo.
1998 • 139 citations
The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography
1992 • 134 citations
Chemical modification of tumour blood flow
1988 • 132 citations
Accelerated radiotherapy with carbogen and nicotinamide (ARCON) for laryngeal cancer
1998 • 111 citations
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
1992 • 106 citations
Changes in tumor hypoxia measured with a double hypoxic marker technique
2000 • 91 citations
Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements
1999 • 83 citations
Application of an Image Analysis System to the Quantitation of Tumor Perfusion and Vascularity in Human Glioma Xenografts
1995 • 79 citations
Accelerated Radiotherapy, Carbogen, and Nicotinamide in Glioblastoma Multiforme: Report of European Organization for Research and Treatment of Cancer Trial 22933
1999 • 78 citations
Covalent binding of a fluorinated 2-nitroimidazole to emt-6 tumors in Balb/C mice: detection by f-19 nuclear magnetic resonance at 2.35 T
1986 • 78 citations
Vascular density in melanoma xenografts correlates with vascular permeability factor expression but not with metastatic potential
1997 • 69 citations
Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide
1999 • 69 citations
Aggressive multimodality treatment for locally advanced irresectable rectal cancer
1997 • 65 citations
Longevity of Pimonidazole Adducts in Spontaneous Canine Tumors as an Estimate of Hypoxic Cell Lifetime
1997 • 65 citations
pH i , Aerobic Glycolysis and Vascular Endothelial Growth Factor in Tumour Growth
2001 • 62 citations
Multiparameter analysis of vasculature, perfusion and proliferation in human tumour xenografts
1998 • 62 citations
Immunohistochemical detection of a hypoxia marker in spontaneous canine tumours
1990 • 61 citations
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen, and nicotinamide.
1999 • 61 citations
Carbogen and nicotinamide in the treatment of bladder cancer with radical radiotherapy
1997 • 58 citations
Mitomycin-C as a prototype bioreductive alkylating agent: In vitro studies of metabolism and cytotoxicity
1982 • 57 citations
Effect of carbogen breathing on the physiological profile of human glioma xenografts
1999 • 56 citations
Variability in blood flow and pO2 in tumors in response to carbogen breathing
1998 • 52 citations
Effect of glucose and deoxyglucose on the redistribution of calcium in Ehrlich ascites tumour and Zajdela hepatoma cells and its consequences for mitochondrial energetics
1999 • 50 citations
The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.
1984 • 50 citations
Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes
2000 • 49 citations
ARCON: accelerated radiotherapy with carbogen and nicotinamide in non small cell lung cancer: a phase I/II study by the EORTC
1999 • 49 citations
Aggressive multimodality treatment for locally advanced irresectable rectal cancer
1997 • 45 citations
Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone
2001 • 44 citations
Interrelationships between microvessel density, expression of VEGF and resistance to doxorubicin of non-small lung cell carcinoma.
1996 • 42 citations
The effects of hyperoxic and hypercarbic gases on tumour blood flow
1999 • 41 citations
Effect of carbogen breathing on tumour microregional blood flow in humans
1996 • 41 citations
Effects of different levels of hypercapnic hyperoxia on tumour R 2 ∗ and arterial blood gases
2001 • 40 citations
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma
1999 • 40 citations
Glucose effect on respiration: Possible mechanism for capacitation in guinea pig spermatozoa
1979 • 37 citations
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2000 • 32 citations
Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined
1995 • 30 citations
Lactate formation by rat small intestine in vitro
1975 • 28 citations
Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas
1996 • 24 citations
The effect of nicotinic acid on glycolytic carbohydrate breakdown in the liver
1967 • 23 citations
The effects of host carbogen (95% oxygen/5% carbon dioxide) breathing on metabolic characteristics of Morris hepatoma 9618a
1998 • 22 citations
Lack of perfusion enhancement after administration of nicotinamide and carbogen in patients with glioblastoma: a 99mTc-HMPAO SPECT study
1998 • 20 citations
Possible mechanisms involved in tumor radiosensitization following nicotinamide administration
1994 • 18 citations
Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: A new modality treatment
1997 • 17 citations
Carcinoma of the larynx treated with hypofractionated radiation and hyperbaric oxygen: long-term tumor control and complications
1999 • 16 citations
Nicotinamide reduces tumour interstitial fluid pressure in a dose- and time-dependent manner.
1997 • 16 citations
The addition of carbogen and nicotinamide to a palliative fractionation schedule for locally advanced breast cancer
1995 • 16 citations
The Effect of Nicotinamide on Microregional Blood Flow Within Tumours Assessed Using Laser Doppler Probes
1995 • 14 citations
Oxygen Transport To Tissue XXIII
2003 • 14 citations
Stimulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) activity by low concentrations of circulating glucose in perfused rat liver
1975 • 11 citations
Effects of nicotinamide and structural analogs on DNA synthesis and cellular replication of rat hepatoma cells.
1984 • 10 citations
Hypoxic radiosensitizers in radical radiotherapy for patients with bladder carcinoma: hyperbaric oxygen, misonidazole, and accelerated radiotherapy, carbogen and nicotinamide.
2000 • 9 citations
Effects of Nicotinamide, Isonicotinamide, and Bleomycin on DNA Synthesis and Repair in Rat Hepatocytes and Hepatoma Cells<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>
1982 • 9 citations
Clinical markers of hypoxia and other predictive factors of survival in conservative therapy of squamous-cell carcinoma of the esophagus
2003 • 6 citations
Nicotinamide and pentoxifylline increase human leucocyte filterability: a possible mechanism for reduction of acute hypoxia.
1996 • 6 citations
The anti-proliferative effects of nicotinamide and 3-aminobenzamide on human smooth muscle cells in vitro.
1993 • 5 citations
Effects of nicotinamide on clonal rat insulinoma cell proliferation, polyamine content and insulin secretion.
1993 • 4 citations
The Effect of Nicotinamide & Hyperoxic Gases on Blood Glucose
2003 • 2 citations