Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

1991 • 950 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Imaging of hypoxia in human tumors with [F-18]fluoromisonidazole

1992 • 470 citations

Tumor hypoxia: its impact on cancer therapy

1987 • 410 citations

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

1991 • 349 citations

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

1994 • 301 citations

Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography

1995 • 284 citations

Tumor tissue oxygenation as evaluated by computerized-po2-histography

1990 • 255 citations

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

1986 • 251 citations

Hypoxia in Tumors: A Paradigm for the Approach to Biochemical and Physiologic Heterogeneity

1988 • 246 citations

Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole.

1992 • 218 citations

Radiolabeled fluoromisonidazole as an imaging agent for tumor hypoxia

1989 • 194 citations

Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression.

1994 • 185 citations

Tumor Oxygenation: A New Predictive Parameter in Locally Advanced Cancer of the Uterine Cervix

1993 • 184 citations

Intercapillary Distance, Oxygen Tension and Local Recurrence in Cervix Cancer

1968 • 174 citations

Characterization of Radiolabeled Fluoromisonidazole as a Probe for Hypoxic Cells

1987 • 172 citations

Characterization of radiolabeled fluoromisonidazole as a probe for hypoxic cells.

1987 • 168 citations

Oxygenation of head and neck tumors

1993 • 167 citations

Non-invasive assessment of human tumour hypoxia with 123I-iodoazomycin arabinoside: preliminary report of a clinical study

1992 • 161 citations

A radiosynthesis of fluorine-18 fluoromisonidazole.

1989 • 129 citations

Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma.

1989 • 126 citations

Imaging tumor hypoxia and tumor perfusion.

1993 • 125 citations

Radioiodinated 1-(5-iodo-5-deoxy-beta-D-arabinofuranosyl)-2-nitroimidazole (iodoazomycin arabinoside: IAZA): a novel marker of tissue hypoxia.

1991 • 121 citations

Effects of Reoxygenation on Cells From Hypoxic Regions of Solid Tumors: Anticancer Drug Sensitivity and Metastatic Potential

1990 • 119 citations

Characteristics of the Binding of Labeled Fluoromisonidazole in Cells in Vitro

1990 • 119 citations

The detection and measurement of hypoxic cells in solid tumors

1984 • 117 citations

Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules

1990 • 111 citations

Pretreatment oxygenation profiles of human soft tissue sarcomas

1994 • 108 citations

Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance

1991 • 108 citations

Oxygen tension in human tumors: in vivo mapping using CT-guided probes.

1985 • 102 citations

Correlations between 31 P-NMR Spectroscopy and Tissue O 2 Tension Measurements in a Murine Fibrosarcoma

1989 • 97 citations

A modeling approach for quantifying tumor hypoxia with [F‐18]fluoromisonidazole PET time‐activity data

1995 • 95 citations

Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance.

1987 • 91 citations

Detection of Hypoxic cells in a Murine Tumour With the Use of the Comet Assay

1992 • 82 citations

Performance measurements of the SP3000/UW time-of-flight positron emission tomograph

1988 • 76 citations

Effect of Transient Hypoxia on Sensitivity to Doxorubicin in Human and Murine Cell Lines

1990 • 76 citations

Tumor progression: Potential role of unstable genomic changes

1990 • 66 citations

Normal Fibroblasts Responding to Anoxia Exhibit Features of the Malignant Phenotype

1989 • 58 citations

Preclinical studies of porfiromycin as an adjunct to radiotherapy.

1988 • 55 citations

Cryospectrophotometric Determination of Tumor Intravascular Oxyhemoglobin Saturations: Dependence on Vascular Geometry and Tumor Growth

1988 • 50 citations

Preclinical Studies of Porfiromycin as an Adjunct to Radiotherapy

1988 • 43 citations

The effect of hypoxia on acquired drug resistance and response to epidermal growth factor in chinese hamster lung fibroblasts and human breast‐cancer cells in vitro

1993 • 43 citations

Effect of some proliferative and environmental factors on the toxicity of mitomycin C to tumor cellsin vitro

1986 • 42 citations

High-speed automated discrete blood sampling for positron emission tomography.

1993 • 36 citations

Effects of reoxygenation on cells from hypoxic regions of solid tumors: analysis of transplanted murine tumors for evidence of DNA overreplication.

1990 • 22 citations

Tissue distribution of 14C- and 3H-labelled misonidazole in the tumor-bearing mouse

1990 • 18 citations

Improving the performance of the SP-3000 PET detector modules

1992 • 11 citations