Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Vascular Endothelial Growth Factor

2009 • 1,276 citations

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 • 1,246 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1996 • 930 citations

Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

1981 • 743 citations

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

1994 • 556 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 366 citations

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

1992 • 355 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Hypoxic cervical cancers with low apoptotic index are highly aggressive.

1999 • 328 citations

Pimonidazole: A Novel Hypoxia Marker for Complementary Study of Tumor Hypoxia and Cell Proliferation in Cervical Carcinoma

1998 • 320 citations

Defective terminal differentiation in culture as a consistent and selectable character of malignant human keratinocytes

1980 • 319 citations

Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.

2001 • 315 citations

Comparisons among Pimonidazole Binding, Oxygen Electrode Measurements, and Radiation Response in C3H Mouse Tumors

1999 • 299 citations

Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver

1995 • 296 citations

Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: A possible signal for vessel development

2001 • 293 citations

Hypoxia and radiation response in human tumors

1996 • 279 citations

Involucrin and Other Markers of Keratinocyte Terminal Differentiation

1983 • 276 citations

Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation.

2002 • 262 citations

Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.

1998 • 244 citations

Tumor Hypoxia Has Independent Predictor Impact Only in Patients With Node-Negative Cervix Cancer

2002 • 234 citations

GLUT‐1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding

2003 • 216 citations

Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.

2001 • 205 citations

The Regulation of Hypoxic Genes by Calcium Involves c-Jun/AP-1, Which Cooperates with Hypoxia-Inducible Factor 1 in Response to Hypoxia

2002 • 202 citations

Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays

1997 • 201 citations

Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ.

2003 • 199 citations

Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids

1995 • 197 citations

Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity

1995 • 181 citations

Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state

1998 • 179 citations

Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine

1998 • 178 citations

Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.

1999 • 162 citations

Regulation of Human Involucrin Promoter Activity by a Protein Kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 Signal Transduction Pathway

1998 • 149 citations

Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1 alpha stabilization: a role for phosphatidylinositol 3'-kinase.

2002 • 147 citations

The Role of Oxygen Concentration in Oxidative Stress: Hypoxic and Hyperoxic Models

1985 • 146 citations

HIF-1α, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors

2002 • 117 citations

Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts

1990 • 113 citations

Visual Imaging of Ion Distribution in Human Epidermis

2000 • 108 citations

The Response of c-Jun/AP-1 to Chronic Hypoxia Is Hypoxia-Inducible Factor 1α Dependent

2002 • 101 citations

Transcription factor regulation of epidermal keratinocyte gene expression

1996 • 100 citations

Expression of hypoxia-inducible factor-1α in cervical carcinomas: correlation with tumor oxygenation

2002 • 97 citations

Expression of vascular endothelial growth factor in normal epidermis, epithelial tumors and cultured keratinocytes

1997 • 93 citations

OXYGEN DIFFUSION AND OXYGEN DEPLETION PROBLEMS IN RADIOBIOLOGY.

1969 • 92 citations

Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types

1995 • 90 citations

Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry

1996 • 89 citations

Evidence for Separate Control Mechanisms at the Message, Protein, and Enzyme Activation Levels for Transglutaminase During Calcium-Induced Differentiation of Normal and Transformed Human Keratinocytes

1996 • 70 citations

Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

1987 • 66 citations

A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.

2000 • 64 citations

Metallothionein and Fas (CD95) are expressed in squamous cell carcinoma of the tongue

1997 • 57 citations

DNA Accessibility: A Determinant of Mammalian Cell Differentiation?

1983 • 56 citations

Analysis of the 5'-Upstream Promoter Region of Human Involucrin Gene: Activation by 12-O-Tetradecanoylphorbol-13-Acetate

1993 • 51 citations

Variation in mitochondrial function in hypoxia-sensitive and hypoxia-tolerant human glioma cells

2002 • 49 citations

Regulation of Gene Expression and Acceleration of Differentiation in Human Keratinocytes by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1994 • 49 citations

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation

2002 • 48 citations

A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines

1999 • 47 citations

Relationship of hypoxia to metallothionein expression in murine tumors

1998 • 41 citations

Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.

2003 • 40 citations

Anomalous patterns of nitroimidazole binding adjacent to necrosis in human glioma xenografts: possible role of decreased oxygen consumption

1997 • 38 citations

Secretion rates and levels of vascular endothelial growth factor in clone A or HCT‐8 human colon tumour cells as a function of oxygen concentration

1995 • 36 citations

An enzyme-linked immunosorbent assay for hypoxia marker binding in tumours

1994 • 31 citations

Heterogeneous expression of keratin, involucrin, and extracellular matrix among subpopulations of a poorly differentiated human cervical carcinoma: possible relationships to patterns of invasion.

1989 • 31 citations

Regulation of ATP synthase subunit e gene expression by hypoxia: cell differentiation stage-specific control

1997 • 31 citations

Radiation sensitivity of human squamous cell carcinoma cells in vitro is modulated by all-trans and 13-cis-retinoic acid in combination with interferon-α

1999 • 29 citations

ELISA quantification of CCI-103F binding in canine tumors prior to and during irradiation

1994 • 28 citations

Variable presence of hypoxia in M006 human glioma spheroids and in spheroids and xenografts of clonally derived sublines

1998 • 22 citations

Suppression of keratinocyte differentiation in SSC-9 human squamous carcinoma cells by benzo(a)pyrene, 12-O-tetradecanoylphorbol-13-acetate and hydroxyurea

1988 • 20 citations

Chronic hypoxia induces LLC-PK1 cell proliferation and dedifferentiation by the activation of protein kinase C

1997 • 18 citations

MIB-1 and involucrin expression in laryngeal squamous carcinoma: the relationship to host and tumour factors and survival

1996 • 11 citations

Effects of the Differentiating Agents Sodium Butyrate and N-Methylformamide on the Oxygen Enhancement Ratio of Human Colon Tumor Cells

1988 • 11 citations

An analysis of changes in oxygen tension in stirred cellular suspensions under conditions of radiolytic and cellular consumption.

1980 • 7 citations