Microsomal Ethanol‐Oxidizing System (MEOS): The First 30 Years (1968‐1998)–A Review

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

High Blood Alcohol Levels in Women

1990 • 1,248 citations

Cytochrome P-4502E1: its physiological and pathological role

1997 • 881 citations

Hepatic Microsomal Ethanol-oxidizing System

1970 • 824 citations

Tolerance to, and dependence on, some non-opiate psychotropic drugs.

1971 • 761 citations

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

1991 • 671 citations

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

1998 • 611 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

1968 • 562 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Medical Disorders of Alcoholism

1995 • 515 citations

Alcohol and the liver: 1994 update

1994 • 511 citations

Properties of catalase. Catalysis of coupled oxidation of alcohols

1945 • 441 citations

Acetaminophen Hepatotoxicity in Alcoholics

1986 • 421 citations

PROSPECTIVE EVALUATION OF ALCOHOL ABUSE AND ALCOHOLIC LIVER INJURY IN MEN AS PREDICTORS OF DEVELOPMENT OF CIRRHOSIS

1984 • 411 citations

THE EFFECT OF ETHANOL ON FATTY ACID METABOLISM; STIMULATION OF HEPATIC FATTY ACID SYNTHESIS IN VITRO*

1961 • 410 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

1989 • 320 citations

Quantitative Relationship between Amount of Dietary Fat and Severity of Alcoholic Fatty Liver

1970 • 313 citations

The ultrastructure of fatty liver induced by prolonged ethanol ingestion.

1966 • 311 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Pathogenesis of alcohol-induced accumulation of protein in the liver.

1977 • 308 citations

Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon

1994 • 306 citations

Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane

1993 • 304 citations

The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo.

1972 • 290 citations

Beef Fat Prevents Alcoholic Liver Disease in the Rat

1989 • 283 citations

Ethanol-induced liver fibrosis in rats fed high fat diet

1986 • 279 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Ethanol Induces CYP2E1 by Protein Stabilization

1995 • 264 citations

Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

1977 • 261 citations

The metabolism of acetone in rat.

1984 • 258 citations

Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

1985 • 256 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

Mechanisms of hydroxyl radical formation and ethanol oxidation by ethanol-inducible and other forms of rabbit liver microsomal cytochromes P-450.

1984 • 246 citations

Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates

1993 • 244 citations

Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet

1985 • 236 citations

An Experimental Model of Alcohol Feeding and Liver Injury in the Baboon

1974 • 235 citations

An Intermediate Compound in the Catalase-hydrogen peroxide Reaction.

1947 • 224 citations

Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer

1991 • 222 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

1993 • 216 citations

Small Intestinal Damage and Changes in Cell Population Produced by Ethanol Ingestion in the Rat

1974 • 214 citations

Role of dietary, adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver.

1966 • 213 citations

The Energy Cost of the Metabolism of Drugs, Including Ethanol

1972 • 210 citations

Advances in pharmacology

1999 • 209 citations

Different Regulation and Expression of the Human CYP2E1 Gene Due to the Rsal Polymorphism in the 5'-Flanking Region1

1994 • 209 citations

Physiological Substrates for Rat Alcohol Dehydrogenase Classes: Aldehydes of Lipid Peroxidation, ω-Hydroxyfatty Acids, and Retinoids

1993 • 207 citations

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system

1990 • 202 citations

Ultrastructural alterations in human hepatocytes following ingestion of ethanol with adequate diets.

1966 • 201 citations

Stabilization of Cytochrome P450j Messenger Ribonucleic Acid in the Diabetic Rat

1987 • 199 citations

Multiple mechanisms in the regulation of ethanol‐inducible cytochrome P450IIE1

1990 • 199 citations

Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

1993 • 198 citations

Genetic polymorphism of cytochrome P4502E1 in a Swedish population

1993 • 189 citations

Increased hepatotoxicity of acetaminophen after chronic ethanol consumption in the rat

1981 • 187 citations

Perspectives: do alcohol calories count?

1991 • 179 citations

Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver

1988 • 178 citations

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

1986 • 173 citations

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

1988 • 170 citations

Acetone Metabolism During Diabetic Ketoacidosis

1982 • 169 citations

Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese

1994 • 168 citations

Introduction: Role of lipid peroxidation and oxidative stress in alcohol toxicity

1989 • 166 citations

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors

1995 • 164 citations

Difference in Hepatic Metabolism of Long- and Medium-Chain Fatty Acids: the Role of Fatty Acid Chain Length in the Production of the Alcoholic Fatty Liver*

1967 • 164 citations

In vitro and in vivo inhibitory effect of ethanol and acetaldehyde on O⁶-methylguanine transferase

1988 • 164 citations

Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes

1993 • 164 citations

Acetone Metabolism in Humans During Diabetic Ketoacidosis

1986 • 162 citations

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

1986 • 158 citations

Effects of prolonged ethanol intake in man: role of dietary adipose, and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver.

1966 • 158 citations

Plasma Acetone Metabolism in the Fasting Human

1979 • 157 citations

Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.

1981 • 156 citations

Increased Carbon Tetrachloride Hepatotoxicity, and its Mechanism, After Chronic Ethanol Consumption

1974 • 154 citations

Role of cytochrome P4502E1 in alcoholic liver disease pathogenesis

1993 • 151 citations

Cytochrome P450 2E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects

1995 • 146 citations

Effect of ethanol on ketone metabolism

1970 • 144 citations

Induction of cytochrome P450IIE1 in the obese overfed rat.

1991 • 143 citations

Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats.

1993 • 143 citations

Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury

1989 • 143 citations

Polyenylphosphatidylcholine Decreases Alcohol-Induced Oxidative Stress in the Baboon

1997 • 140 citations

Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats

1988 • 140 citations

Acetaldehyde Oxidation by Hepatic Mitochondria: Decrease After Chronic Ethanol Consumption

1975 • 139 citations

Hepatic microsomal ethanol-oxidizing system: Solubilization, isolation, and characterization

1974 • 138 citations

Formation of acetaldehyde adducts with ethanol-inducible P450IIE1 in vivo

1988 • 137 citations

Alcohol and cancer

1986 • 136 citations

Hepatic microsomal alcohol-oxidizing system. Affinity for methanol, ethanol, propanol, and butanol.

1975 • 136 citations

Human cytochrome from genotype to phenotype

1996 • 135 citations

Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques

1993 • 134 citations

Increased NADPH- and NADH-Dependent Production of Superoxide and Hydroxyl Radical by Microsomes after Chronic Ethanol Treatment

1993 • 133 citations

Polyenylphosphatidylcholine prevents carbon tetrachloride-induced lipid peroxidation while it attenuates liver fibrosis

1997 • 129 citations

Genetic polymorphisms of cytochrome P4502E1 related to the development of alcoholic liver disease

1994 • 129 citations

The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finish study population

1993 • 129 citations

Purification and characterization of human liver cytochrome P-450-ALC

1987 • 128 citations

Binding of acetaldehyde to rat liver microsomes: Enhancement after chronic alcohol consumption

1981 • 128 citations

Respective Roles of Human Cytochrome P‐4502E1, 1A2, and 3A4 in the Hepatic Microsomal Ethanol Oxidizing System

1998 • 125 citations

Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes.

1988 • 121 citations

Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes.

1992 • 119 citations

Microsomal ethanol-oxidizing system (MEOS): Purification and properties of a rat liver system free of catalase and alcohol dehydrogenase

1972 • 119 citations

Polyunsaturated lecithin prevents acetaldehyde-mediated hepatic collagen accumulation by stimulating collagenase activity in cultured lipocytes

1992 • 119 citations

Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract

1990 • 118 citations

Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics

1998 • 117 citations

Cytochrome P450IIE1 Is Elevated in Lymphocytes from Poorly Controlled Insulin-Dependent Diabetics^*

1990 • 116 citations

Utilization of long chain fatty acids by rat liver: Studies of the role of fatty acid binding protein

1979 • 116 citations

Genetic Polymorphism of Cytochromes P450 1A1, 2D6 and 2E1: Regulation and Toxicological Significance

1995 • 112 citations

Regulation of Hepatic Microsomal Cytochrome P450IIE1 Level by Dietary Lipids and Carbohydrates in Rats

1991 • 112 citations

Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation

1998 • 110 citations

Oxygen radical generation by microsomes: Role of iron and implications for alcohol metabolism and toxicity

1989 • 107 citations

Induction of Cytochrome P450 2E1 during Chronic Ethanol Exposure Occurs via Transcription of the Cyp 2E1 Gene When Blood Alcohol Concentrations Are High

1993 • 107 citations

Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.

1989 • 107 citations

Restriction fragment length polymorphism of the human CYP 2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer

1994 • 105 citations

Microsomal Ethanol Oxidizing System (MEOS): Current Status of Its Characterization and Its Role

1977 • 105 citations

Alcohol and Lipids

1998 • 104 citations

Hepatic cytochrome P-450j induction in the spontaneously diabetic BB rat.

1988 • 102 citations

The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes

1977 • 101 citations

Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis

1995 • 99 citations

Lipid Peroxidation, CYP2E1 and Arachidonic Acid Metabolism in Alcoholic Liver Disease in Rats

1997 • 99 citations

Ethanol oxidation by liver microsomes: Evidence against a separate and distinct enzyme system

1970 • 98 citations

The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450

1978 • 98 citations

Medical and Nutritional Complications of Alcoholism

1992 • 96 citations

In Vivo Induction of Hepatic P4502E1 by Ethanol: Role of Increased Enzyme Synthesis

1993 • 96 citations

Transcriptional control of the rat hepatic CYP2E1 gene.

1990 • 95 citations

Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans

1997 • 94 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA,

1993 • 94 citations

Insulin effects on CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes

1997 • 94 citations

Acetaldehyde as a substrate for ethanol-inducible cytochrome P450 (CYP2E1)

1991 • 89 citations

Ethanol oxidation in the microsomal fraction of rat liver

1969 • 88 citations

Inhibition of cytochrome P450 2E1 expression by 2-(allylthio)Pyrazine, a Potential chemoprotective agent: hepatoprotective Effects

1997 • 88 citations

More Rapid Elimination of Alcohol in Women as Compared to Their Male Siblings

1989 • 87 citations

Enhanced pulmonary and intestinal activation of procarcinogens and mutagens after chronic ethanol consumption in the rat

1981 • 87 citations

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype

1998 • 85 citations

Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation

1990 • 84 citations

Immunochemical identification of cytochrome P-450 isozyme 3a (P-450ALC) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol.

1986 • 81 citations

Hepatic and other medical disorders of alcoholism: from pathogenesis to treatment.

1998 • 81 citations

Polyenylphosphatidylcholine Attenuates Alcohol-Induced Fatty Liver and Hyperlipemia in Rats , ,

1997 • 81 citations

Decrease in Cytochrome P4502E1 as Assessed by the Rate of Chlorzoxazone Hydroxylation in Alcoholics during the Withdrawal Phase

1995 • 80 citations

Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression

1996 • 80 citations

Role of acetone, dietary fat and total energy intake in induction of hepatic microsomal ethanol oxidizing system.

1988 • 79 citations

Cytochrome P4502E1 is present in rat pancreas and is induced by chronic ethanol administration

1998 • 77 citations

Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to alcoholic liver cirrhosis.

1994 • 77 citations

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians

1995 • 75 citations

Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line.

1995 • 75 citations

Estrogen‐Related Acetaldehyde Elevation in Women during Alcohol Intoxication

1996 • 74 citations

Hepatic microsomal ethanol oxidizing system (MEOS): Respective roles of ethanol and carbohydrates for the enhanced activity after chronic alcohol consumption

1981 • 73 citations

A NEW ORAL LOW-CARBOHYDRATE ALCOHOL LIQUID DIET PRODUCING LIVER LESIONS: A PRELIMINARY ACCOUNT

1998 • 73 citations

Alcohol consumption enhances fatty acid ω-oxidation, with a greater increase in male than in female rats

1993 • 72 citations

Non-uniformity of blood ethanol elimination: its exaggeration after chronic consumption.

1978 • 71 citations

Ethanol Oxidation by a Component of Liver Microsomes Rich in Cytochrome P-450

1973 • 71 citations

Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation.

1995 • 71 citations

Identification and induction of cytochrome P450 2E1 in rat Kupffer cells.

1991 • 70 citations

Increased oxygen radical‐dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption

1988 • 70 citations

Induction of Cytochrome P‐4502E1 by Ethanol in Rat Kupffer Cells

1996 • 69 citations

Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone.

1998 • 69 citations

Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes.

1989 • 68 citations

NADPH-dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes

1974 • 67 citations

Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung, and hepatic tissue.

1985 • 67 citations

Effects of Fatty Acids and Ketone Bodies on Cytochromes P450 2B, 4A, and 2E1 Expression in Primary Cultured Rat Hepatocytes

1997 • 67 citations

Mechanisms of regulation of liver fatty acid-binding protein

1993 • 66 citations

Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease.

1995 • 66 citations

Comparison of Levels of Cytochromes P‐450, CYP1A2, CYP2E1, and Their Related Monooxygenase Activities in Human Surgical Liver Samples

1993 • 65 citations

Evidence That Cytochrome-P450 2E1 Is Involved in the (ω-1)-Hydroxylation of Lauric Acid in Rat Liver Microsomes

1994 • 65 citations

Effects of butylated hydroxytoluene on the ultrastructure of rat hepatocytes.

1967 • 65 citations

Polymorphism at the P450IIE1 Locus Is Not Associated with Alcoholic Liver Disease in Caucasian Men

1995 • 65 citations

Role of Superoxide and Trace Transition Metals in the Production of α-Hydroxyethyl Radical from Ethanol by Microsomes from Alcohol Dehydrogenase-Deficient Deermice

1993 • 64 citations

Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s.

1996 • 63 citations

cDNA and derived amino acid sequence of ethanol-inducible rabbit liver cytochrome P-450 isozyme 3a (P-450ALC).

1987 • 61 citations

Relationship between cytochrome P450 2E1 and acetone catabolism in rats as studied with diallyl sulfide as an inhibitor

1994 • 61 citations

Brain Mitochondrial Cytochromes P450: Xenobiotic Metabolism, Presence of Multiple Forms and Their Selective Inducibility

1995 • 61 citations

Polyenylphosphatidylcholine Opposes the Increase of Cytochrome P‐4502E1 by Ethanol and Corrects Its Iron‐Induced Decrease

1999 • 59 citations

Alcohol Metabolism: Role of Microsomal Oxidation in vivo

1969 • 59 citations

Hydroxylation of acetone by ethanol‐ and acetone‐inducible cytochrome P‐450 in liver microsomes and reconstituted membranes

1986 • 59 citations

Evidence for increased translational efficiency in the induction of P450IIE1 by solvents: Analysis of P450IIE1 mRNA polyribosomal distribution

1990 • 59 citations

Molecular regulation of ethanol-inducible cytochrome P450-IIEI in hamsters

1988 • 57 citations

Tissue-specific expression and methylation of the human CYP2E1 gene

1994 • 56 citations

The Detection of Cytochrome P450 2E1 and Its Catalytic Activity in Rat Testis

1998 • 56 citations

Respective role of superoxide and hydroxyl radical in the activity of the reconstituted microsomal ethanol-oxidizing system

1978 • 56 citations

Gender-Related Differences in Susceptibility to Acetaminophen-Induced Protein Arylation and Nephrotoxicity in the CD-1 Mouse

1995 • 55 citations

On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs

1967 • 54 citations

Involvement of cytochrome P450 2E1 in the (ω–1)-hydroxylation of oleic acid in human and rat liver microsomes

1998 • 54 citations

Effect of ethanol on fatty acid metabolism in liver slices

1959 • 51 citations

An Rsa I Polymorphism in the CYP2E1 Gene Does Not Affect Lung Cancer Risk in a Japanese Population

1995 • 49 citations

Ethanol Increases Content and Activity of Human Cytochrome P4502E1 in a Transduced HepG2 Cell Line

1994 • 49 citations

Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats

1996 • 47 citations

Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat

1983 • 47 citations

Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. off.

1995 • 46 citations

Interaction of Ethanol with Enflurane Metabolism and Toxicity: Role of P450IIE1

1990 • 45 citations

The Role of Alcohol Dehydrogenase in Microsomal Ethanol Oxidation and the Adaptive Increase in Ethanol Metabolism due to Chronic Treatment With Ethanol

1977 • 45 citations

Characterization of cytochrome P450 2E1 induction in a rat hepatoma FGC-4 cell model by ethanol

1994 • 43 citations

High Inducibility of Mouse Renal CYP2E1 Gene by Tobacco Smoke and Its Possible Effect on DNA Single Strand Breaks

1996 • 42 citations

Potentiation of halothane hepatotoxicity by chronic ethanol administration in rat: An animal model of halothane hepatitis

1983 • 42 citations

Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells

1995 • 39 citations

CYTOCHROME <italic>P</italic>-450 2E1 IN RAT LIVER, KIDNEY AND LUNG MICROSOMES AFTER CHRONIC ADMINISTRATION OF ETHANOL EITHER ORALLY OR BY INHALATION

1995 • 37 citations

Hormone controlled phosphorylation and degradation of CYP2B1 and CYP2E1 in isolated rat hepatocytes

1991 • 37 citations

Chlorzoxazone pharmacokinetics as a marker of hepatic cytochrome P4502E1 in humans

1998 • 36 citations

Collagen Synthesis by Liver Stellate Cells Is Released from Its Normal Feedback Regulation by Acetaldehyde‐Induced Modification of the Carboxyl‐Terminal Propeptide of Procollagen

1997 • 36 citations

Induction of cytochrome P-450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone.

1990 • 36 citations

Renal Tumorigenicity of 1,1-Dichloroethene in Mice: The Role of Male-Specific Expression of Cytochrome P450 2E1 in the Renal Bioactivation of 1,1-Dichloroethene

1995 • 35 citations

Kinetic studies on benzene metabolism in rat liver—possible presence of three forms of benzene metabolizing enzymes in the liver

1987 • 35 citations

Effect of Abstinence on the Blood Acetaldehyde Response to a Test Dose of Alcohol in Alcoholics

1987 • 33 citations

Absence of ethanol metabolism in ‘acatalatic’ hepatic microsomes that oxidize drugs

1973 • 32 citations

Gender differences in medium-chain dicarboxylic aciduria in alcoholic men and women

1999 • 32 citations

Roles of pituitary hormones in the regulation of hepatic cytochrome P450IIE1 in rats and mice

1990 • 31 citations

Contribution of Cytochrome P450S To Meos (Microsomal Ethanol-Oxidizing System): A Specific and Sensitive Assay of Meos Activity by HPLC with Fluorescence Labeling

1993 • 31 citations

Polyenylphosphatidylcholine decreases alcoholic hyperlipemia without affecting the alcohol-induced rise of HDL-cholesterol

1997 • 31 citations

Ethanol interferes with regeneration-associated changes in biotransforming enzymes: A potential mechanism underlying ethanol's carcinogenicity?

1991 • 30 citations

Selective Inhibition of Cytochrome P450 2E1 in Vivo and in Vitro withtrans-1,2-Dichloroethylene

1998 • 28 citations

[11] Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance

1994 • 27 citations

Gender Differences in the Response of Hepatic Fatty Acids and Cytosolic Fatty Acid-Binding Capacity to Alcohol Consumption in Rats

1991 • 27 citations

Intestinal Toxicity of Acrylonitrile: In Vitro Metabolism by Intestinal Cytochrome P450 2E1

1995 • 27 citations

Inducibility of Cytochromes P‐4502E1 and P‐4501A1 in the Rat Pancreas

1998 • 26 citations

Measurement of acetol in serum

1985 • 26 citations

Influence of alcohol, dithiocarb and (+)‐catechin on the hepatotoxicity and metabolism of vinylidene chloride in rats

1983 • 25 citations

Hepatic microsomal alcohol-oxidizing system in normal and acatalasemic mice: its dissociation from the peroxidatic activity of catalase-H2O2.

1975 • 25 citations

Zonation of cytochrome P450 enzyme expression in rat liver

1996 • 24 citations

THE CAPACITY OF MACROPHAGES FROM DIFFERENT MURINE TISSUES TO METABOLISE ETHANOL AND GENERATE AN ETHANOL-DEPENDENT NON-DIALYSABLE CYTOTOXIC ACTIVITY <italic>IN VITRO</italic>

1987 • 23 citations

Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically

1995 • 22 citations

Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450S

1995 • 21 citations

Regulation of the HepaticCYP2E1 Gene During Chronic Alcohol Exposure: Lack of an Ethanol Response Element in the Proximal 5′-Flanking Sequence

1997 • 21 citations

Microsomal Acetaldehyde Oxidation is Negligible in the Presence of Ethanol

1998 • 21 citations

Immunohistochemical Determination of Hepatic Cytochrome P‐4502E1 in Formalin‐Fixed, Paraffin‐Embedded Sections

1997 • 20 citations

[Alcohol and free radicals: from basic research to clinical prospects].

1995 • 20 citations

Oxidation of ethanol by hepatic microsomes of acatalasemic mice

1974 • 20 citations

Effect of combined phenylbutazone and ethanol administration on rat liver

1980 • 19 citations

Ethanol and intestinal carcinogenesis in the rat

1985 • 18 citations

The production of 1,2-propanediol in ethanol treated rats

1985 • 16 citations

Evidence for a Tissue-Specific Induction of Cutaneous CYP2E1 by Dexamethasone

1997 • 14 citations

Enhancement of ethanol-induced lipid peroxidation in rat liver by lowered carbohydrate intake

1992 • 13 citations

Effects of carbohydrate intake on the blood ethanol level and alcoholic fatty liver damage in rats

1993 • 13 citations

Stable expression of human cytochrome P450 2E1 in V79 Chinese hamster cells

1995 • 13 citations

The Photochemical Action Spectrum of the Microsomal Ethanol Oxidizing System

1979 • 13 citations

Positive Correlation between Cytochrome P450 2E1 mRNA Level and Serum Estradiol Level in Human Uterine Endometrium

1994 • 10 citations

CARBOHYDRATE DEFICIENCY AS A POSSIBLE FACTOR IN ETHANOL‐INDUCED HEPATIC NECROSIS

1998 • 10 citations

Effects of diet and ethanol treatment on azoxymethane-induced livei and gastrointestinal neoplasia of male rats

1996 • 4 citations