Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Genomic sequencing.

1984 • 8,343 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic Studies

1962 • 1,431 citations

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

Random subcloning of sonicated DNA: Application to shotgun DNA sequence analysis

1983 • 605 citations

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

1985 • 593 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Relevance of nitrosamines to human cancer

1984 • 489 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

1980 • 286 citations

The metabolism of acetone in rat.

1984 • 258 citations

Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes.

1985 • 256 citations

Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

1982 • 235 citations

Human Dioxin-Inducible Cytochrome P ₁ -450: Complementary DNA and Amino Acid Sequence

1985 • 233 citations

Genes for Cytochrome P-450 and Their Regulatio

1986 • 227 citations

Transcriptional regulation of rat liver epoxide hydratase, NADPH-Cytochrome P-450 oxidoreductase, and cytochrome P-450b genes by phenobarbital.

1983 • 222 citations

Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes.

1985 • 221 citations

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.

1985 • 215 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

1985 • 181 citations

Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues.

1986 • 177 citations

Structural gene products of the Ah locus. Transcriptional regulation of cytochrome P1-450 and P3-450 mRNA levels by 3-methylcholanthrene.

1984 • 157 citations

Molecular structure and evolutionary origin of human cardiac muscle actin gene.

1982 • 155 citations

A cytochrome P-450 multigene family. Characterization of a gene activated by phenobarbital administration.

1983 • 137 citations

Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

1984 • 129 citations

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC

1984 • 129 citations

The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol

1982 • 127 citations

Chromosomal assignments of genes coding for components of the mixed-function oxidase system in mice. Genetic localization of the cytochrome P-450PCN and P-450PB gene families and the nadph-cytochrome P-450 oxidoreductase and epoxide hydratase genes.

1985 • 123 citations

Cloning of DNA complementary to rat liver NADPH-cytochrome c (P-450) oxidoreductase and cytochrome P-450b mRNAs. Evidence that phenobarbital augments transcription of specific genes.

1982 • 120 citations

Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat.

1985 • 104 citations

Isolation and sequence analysis of three cloned cDNAs for rabbit liver proteins that are related to rabbit cytochrome P-450 (form 2), the major phenobarbital-inducible form

1984 • 97 citations

Comparison of the flanking regions and introns of the mouse 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 and P3-450 genes.

1985 • 96 citations

Studies on the mechanisms of induction of N-nitrosodimethylamine demethylase by fasting, acetone, and ethanol

1984 • 93 citations

Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA.

1986 • 92 citations

Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

1983 • 85 citations

Cytochrome P450 gene expression and regulation

1985 • 85 citations

Immunochemical evidence for a role of cytochrome P-450 in liver microsomal ethanol oxidation

1984 • 84 citations

Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol

1983 • 78 citations

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

1983 • 78 citations

Demethylation and denitrosation of nitrosamines by cytochrome P-450 isozymes

1985 • 71 citations

Alterations of microsomal monooxygenase system and carcinogen metabolism by streptozotocin-induced diabetes in rats

1983 • 69 citations

Immunochemical studies on the metabolism of nitrosamines by ethanol-inducible cytochrome P-450

1985 • 67 citations

Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response.

1983 • 66 citations

Effect of diabetes on rat liver cytochrome P-450

1982 • 63 citations

Multiplicity of deoxyribonucleic acid sequences with homology to a cloned complementary deoxyribonucleic acid coding for rat phenobarbital-inducible cytochrome P-450

1983 • 63 citations

Gene conversion in a cytochrome P-450 gene family.

1986 • 56 citations

Cloning and characterization of cDNAs encoding 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for cytochrome P-450 isozymes 4 and 6.

1985 • 55 citations

Detection and purification of cytochromes P-450 in animal tissues with monoclonal antibodies.

1984 • 48 citations

Preparation and characterization of monoclonal antibodies to pregnenolone 16-α-carbonitrile inducible rat liver cytochrome P-450

1986 • 44 citations

Monoclonal antibodies to ethanol induced cytochrome P-450 that inhibit aniline and nitrosamine metabolism

1986 • 40 citations

Developmental regulation of the hepatocyte receptor for galactose-terminated glycoproteins

1985 • 33 citations