Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Transection of the oesophagus for bleeding oesophageal varices

1973 • 7,698 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

1973 • 504 citations

A practical approach for quantitating specific mRNAs by solution hybridization

1983 • 427 citations

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

1986 • 408 citations

MEDICAL NEMESIS

1974 • 377 citations

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

1989 • 277 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

1992 • 228 citations

[11] Radioiodination of proteins by the use of the chloramine-T method

1980 • 225 citations

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

1995 • 219 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

1993 • 216 citations

The induction of a specific form of cytochrome P-450 (P-450j) by fasting

1987 • 212 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Stabilization of Cytochrome P450j Messenger Ribonucleic Acid in the Diabetic Rat

1987 • 199 citations

P450 Enzymes

1992 • 181 citations

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

1986 • 173 citations

Ligand-dependent maintenance of ethanol-inducible cytochrome P-450 in primary rat hepatocyte cell cultures

1988 • 170 citations

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

1993 • 156 citations

Purification and properties of cytochrome P-450 from homogenates of human fetal livers

1985 • 137 citations

Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes

1979 • 133 citations

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age

1991 • 118 citations

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

1987 • 112 citations

Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA,

1993 • 94 citations

Induction of rat hepatic P450IIE1 (CYP 2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation

1990 • 84 citations

Drug metabolism in cirrhosis

1986 • 77 citations

Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet.

1992 • 74 citations

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.

1986 • 65 citations

Constitutive expression and hormonal regulation of male sexually differentiated cytochromes P450 in primary cultured rat hepatocytes

1992 • 59 citations

Monoclonal Antibody-Directed Radioimmunoassay Detects Cytochrome P-450 in Human Placenta and Lymphocytes

1985 • 56 citations

Hexobarbital disposition in compensated and decompensated cirrhosis of the liver

1978 • 46 citations

Post-translational reduction of cytochrome P450IIE by CCl4, its substrate

1991 • 46 citations

Localization of cytochrome P-450 gene expression in normal and diseased human liver byin situ hybridization of wax-embedded archival material

1992 • 44 citations

Suppression of hepatic levels of an ethanol-inducible P-450DM/j by growth hormone: relationship between the increased level of P-450DM/j and depletion of growth hormone in diabetes.

1989 • 37 citations

Ethanol interferes with regeneration-associated changes in biotransforming enzymes: A potential mechanism underlying ethanol's carcinogenicity?

1991 • 30 citations

Diseases of the liver and biliary tract : standardization of nomenclature, diagnostic criteria, and prognosis

1994 • 27 citations

Pharmacokinetics of Nifedipine After Oral Administration in Chronic Liver Disease

1987 • 20 citations

Quantification of cytochrome P-450 gene expression in human tissues

1990 • 6 citations