On the significance of the hypertrophy of the smooth endoplasmic reticulum in liver cells after administration of drugs

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1966 • 457 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

An electron microscope study of the early effects of 3'-Me-DAB on rat liver cells.

1959 • 339 citations

Ethionine Carcinogenesis

1963 • 296 citations

LIVER PARENCHYMAL CELL INJURY

1963 • 288 citations

AN INTRACELLULAR DEFECT IN PROTEIN SYNTHESIS INDUCED BY CARBON TETRACHLORIDE

1962 • 261 citations

Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes

1955 • 255 citations

Enzyminduktion und Vermehrung von endoplasmatischem Reticulum in der Leberzelle w�hrend der Behandlung mit Phenobarbital (Luminal)

1963 • 221 citations

Liver response tests. III. Liver enlargement and stimulation of microsomal processing enzyme activity

1965 • 211 citations

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.

1965 • 210 citations

The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat.

1960 • 207 citations

The Role of Adenosine Triphosphate Deficiency in Ethionine-induced Inhibition of Protein Synthesis

1963 • 204 citations

Changes in the Fine Structure of Rat Liver Cells Brought about by Dimethylnitrosamine

1960 • 193 citations

STUDIES ON ETHIONINE

1950 • 181 citations

Some factors affecting glucuronide formation in vitro.

1960 • 155 citations

Stimulatory Effect of Foreign Compounds on Ascorbic Acid Biosynthesis and on Drug-Metabolizing Enzymes

1959 • 153 citations

Induced Synthesis of Liver Microsomal Enzymes Which Metabolize Foreign Compounds

1959 • 152 citations

Stimulatory effects of chlordane on hepatic microsomal drug metabolism in the rat

1963 • 146 citations

Der beschleunigte Abbau von Pharmaka in den Lebermikrosomen unter dem Einflu� von Luminal

1959 • 145 citations

ELECTRON MICROSCOPY OF MEMBRANE-PARTICLE ARRAYS IN LIVER CELLS OF ETHIONINE-INTOXICATED RATS.

1964 • 142 citations

Further studies on the stimulation of hepatic microsomal drug metabolizing enzymes by DDT and its analogs

1965 • 128 citations

Microsomal N-demethylation and the effect of the hepatic carcinogen dimethylnitrosamine on amino acid incorporation into the proteins of rat livers and hepatomas

1960 • 125 citations

Inhibition of the ethanol and carbon tetrachloride induced fatty liver by antioxidants

1965 • 111 citations

A LIGHT AND ELECTRON MICROSCOPE STUDY OF THE MORPHOLOGICAL CHANGES INDUCED IN RAT LIVER CELLS BY THE AZO DYE 2-ME-DAB

1964 • 108 citations

STIMULATORY EFFECT OF BARBITAL ON URINARY EXCRETION OF l-ASCORBIC ACID AND NONCONJUGATED d-GLUCURONIC ACID

1957 • 104 citations

FINE STRUCTURAL CHANGES IN RAT LIVER INDUCED BY PHENOBARBITAL.

1964 • 102 citations

Toxic liver injury. Inhibition by dimethylnitrosamine of incorporation of labelled amino acids into proteins of rat-liver preparations in vitro

1960 • 93 citations

ELECTRON MICROSCOPY OF THE CYTOPLASM OF PARENCHYMAL LIVER CELLS IN ALPHA-NAPHTHYL-ISOTHIOCYANATE-INDUCED CIRRHOSIS.

1963 • 93 citations

INDUCTION OF DDT-METABOLIZING ENZYMES IN MICROSOMES OF RAT LIVER AFTER ADMINISTRATION OF DDT

1965 • 89 citations

Elektronen- und lichtmikroskopische Untersuchungen am Cytoplasma der Leberzellen nach akuter und chronischer Thioacetamid-Vergiftung

1962 • 88 citations

Studies of the possible mechanisms by which chlordane stimulates hepatic microsomal drug metabolism in the rat

1965 • 85 citations

Inductive effects of 3-methylcholanthrene on enzyme activities and amino acid incorporation capacity of rat liver microsomes

1960 • 85 citations

ASCORBIC ACID SYNTHESIS IN NORMAL AND DRUG-TREATED RATS, STUDIED WITH l-ASCORBIC-1-C14 ACID

1954 • 84 citations

The biochemistry of aromatic amines. 3. Enzymic hydroxylation by rat-liver microsomes

1957 • 66 citations

The effect of cysteine on the metabolic changes produced by two carcinogenic Nnitrosodialklamines in rat liver.

1962 • 63 citations

Vergleichende Untersuchungen der oxydativen Leistungen von Mitochondrien und Mikrosomen bei experimenteller Lebersch�digung

1959 • 63 citations

Carbon Tetrachloride Poisoning in Rats: Alteration in Ribosomes of the Liver

1963 • 62 citations

REVERSIBLE BIOLOGICAL AND FINE STRUCTURAL CHANGES PRODUCED IN RAT LIVER BY A THIOHYDANTOIN COMPOUND.

1964 • 62 citations

Modifications des cellules du parenchyme hépatique du rat sous l'effet de la thioacétamide

1962 • 60 citations

Induced synthesis of oxidative enzymes in liver microsomes by polycyclic hydrocarbons and drugs

1963 • 59 citations

HEPATIC PARENCHYMAL CELL ALTERATIONS AFTER LONG-TERM CARBON TETRACHLORIDE ADMINISTRATION. A LIGHT AND ELECTRON MICROSCOPIC STUDY.

1963 • 51 citations

Studies on the metabolism of thioacetamide-S35 in the intact rat.

1954 • 43 citations

ENHANCED ANDROGEN HYDROXYLASE ACTIVITY IN LIVER MICROSOMES OF RATS AND DOGS TREATED WITH PHENYLBUTAZONE.

1964 • 42 citations

EFFECTS OF CARCINOGENIC AMINES ON AMINO ACID INCORPORATION BY LIVER SYSTEMS. II. A MORPHOLOGICAL AND BIOCHEMICAL STUDY ON THE EFFECT OF DIMETHYLNITROSAMINE.

1963 • 41 citations

Potentiation and inhibition of alpha-naphthylisothiocyanate-induced hyperbilirubinemia and cholestasis.

1965 • 40 citations

THE FINE STRUCTURE OF HEPATIC CELLS IN CHRONIC ETHIONINE POISONING AND DURING RECOVERY.

1965 • 40 citations

On the mode of action by which the carcinogen dimethylnitrosamine inhibits protein synthesis in the liver

1964 • 38 citations

Modifications des cellules du parenchyme hépatique du rat sous l'effet de la thioacétamide: Étude au microscope électronique des lésions observées à la phase tardive d'une intoxication chronique

1962 • 38 citations

SOME OF THE INTERACTIONS OF SKF 525-A WITH HEPATIC MICROSOMES.

1964 • 38 citations

Hyaline degeneration of rat liver cells studied with the electron microscope.

1960 • 35 citations

ULTRASTRUCTURAL CHANGES IN THE RAT LIVER PRODUCED BY N-2-FLUORENYLDIACETAMIDE.

1964 • 33 citations

Spectrum of fine structural changes in hepatocellular injury due to thioacetamide.

1965 • 32 citations

EFFECTS OF THIOACETAMIDE AND YELLOW PHOSPHORUS POISONING ON PROTEIN SYNTHESIS IN VIVO.

1963 • 32 citations

EXPERIMENTAL TOXIC LIVER INJURY BY SOME NITROSAMINES*

1963 • 30 citations

EFFECT OF ACTINOMYCIN D ON THE HEPATIC CELLS OF PARTIALLY HEPATECTOMIZED RATS. AN ELECTRON MICROSCOPIC STUDY.

1965 • 30 citations

Electron-microscopic study on liver cells of rats treated with actinomycin D

1964 • 27 citations

CHANGES IN FUNCTION AND STRUCTURE OF THE ENDOPLASMIC RETICULUM OF RAT LIVER CELLS AFTER ADMINISTRATION OF CYSTEINE

1962 • 25 citations

Effects of Thioacetamide on Metabolism of Proteins of Normal and Regenerating Liver

1962 • 24 citations

The influence of phenobarbital administration upon the “soluble” NADP-requiring enzymes in liver

1964 • 24 citations

An Anomalous Effect of Ethionine on Ribonucleic Acid Synthesis

1964 • 19 citations

EFFECT OF CORTISONE ON THE FINE STRUCTURE, GLYCOGEN CONTENT, AND GLUCOSE-6-PHOSPHATASE ACTIVITY OF HEPATIC CELLS IN FASTED AND DIMETHYLNITROSAMINE-TREATED RATS.

1964 • 17 citations

Effects of carbon tetrachloride on guinea pig liver

1965 • 15 citations

EFFECTS OF CARCINOGENIC AMINES ON AMINO ACID INCORPORATION BY LIVER SYSTEMS. 3. INHIBITION BY AMINOFLUORENE TREATMENT AND ITS DEPENDENCE ON VITAMIN E.

1965 • 12 citations

Occurrence of Homoserine in the Liver of Ethionine- or Methionine-treated Rats

1964 • 11 citations

Apparent Paradox in the Effects of Ethionine feeding on the Specific Activities of Rat Liver Glucose-6-phosphate Dehydrogenase and Pyruvate Kinase

1965 • 9 citations

Enzymatische Leistungen der Lebermikrosomen bei der �thioninvergiftung

1957 • 8 citations

The effect of ethionine on the increased metabolism of some drugs and increased urinary excretion of vitamin C induced by pretreatment with chloretone or phenobarbital

1962 • 7 citations

Neuere Erkenntnisse zur Geschwulstbildung in der Leber

1962 • 6 citations

Effects of p-Dimethylaminoazobenzene on the Fine Structure of Rat Liver Cells

1963 • 6 citations